Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elspeth M Payne"'
Safety and efficacy of anakinra in hemophagocytic lymphohistiocytosis associated with acute leukemia
Autor:
Hannah Al-Yousuf, Jenny O’Nions, Andrew J Wilson, Satyen Gohil, Jessica J Manson, Elspeth M Payne
Publikováno v:
Haematologica, Vol 109, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/31bf229e0d024c81a4bef172759904c2
Publikováno v:
SLAS Technology, Vol 27, Iss 2, Pp 109-120 (2022)
Fundamental life science and pharmaceutical research are continually striving to provide physiologically relevant context for their biological studies. Zebrafish present an opportunity for high-content screening (HCS) to bring a true in vivo model sy
Externí odkaz:
https://doaj.org/article/7ad7ff4004eb4101a5f53a3af33caaab
Autor:
Ana Rio-Machin, Tom Vulliamy, Nele Hug, Amanda Walne, Kiran Tawana, Shirleny Cardoso, Alicia Ellison, Nikolas Pontikos, Jun Wang, Hemanth Tummala, Ahad Fahad H. Al Seraihi, Jenna Alnajar, Findlay Bewicke-Copley, Hannah Armes, Michael Barnett, Adrian Bloor, Csaba Bödör, David Bowen, Pierre Fenaux, Andrew Green, Andrew Hallahan, Henrik Hjorth-Hansen, Upal Hossain, Sally Killick, Sarah Lawson, Mark Layton, Alison M. Male, Judith Marsh, Priyanka Mehta, Rogier Mous, Josep F. Nomdedéu, Carolyn Owen, Jiri Pavlu, Elspeth M. Payne, Rachel E. Protheroe, Claude Preudhomme, Nuria Pujol-Moix, Aline Renneville, Nigel Russell, Anand Saggar, Gabriela Sciuccati, David Taussig, Cynthia L. Toze, Anne Uyttebroeck, Peter Vandenberghe, Brigitte Schlegelberger, Tim Ripperger, Doris Steinemann, John Wu, Joanne Mason, Paula Page, Susanna Akiki, Kim Reay, Jamie D. Cavenagh, Vincent Plagnol, Javier F. Caceres, Jude Fitzgibbon, Inderjeet Dokal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Familial myeloid malignancies have recently been classified as separate disease entities. Here, using whole-exome sequencing of affected pedigrees - the authors highlight genetic variants associated with these conditions.
Externí odkaz:
https://doaj.org/article/a25bb12eaf454851a551304c03cbab09
Autor:
Oscar A. Peña, Alexandra Lubin, Jasmine Rowell, Yvette Hoade, Noreen Khokhar, Hanna Lemmik, Christopher Mahony, Phoebe Dace, Chianna Umamahesan, Elspeth M. Payne
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Germline loss or mutation of one copy of the transcription factor GATA2 in humans leads to a range of clinical phenotypes affecting hematopoietic, lymphatic and vascular systems. GATA2 heterozygous mice show only a limited repertoire of the features
Externí odkaz:
https://doaj.org/article/024e03d57978457a9084fb5f7643a44d
Autor:
Simon E. Richardson, Duncan Brian, Victoria Grandage, Rachael Hough, Panagiotis Kottaridis, Marc R. Mansour, Elspeth M. Payne, Asim Khwaja
Publikováno v:
HemaSphere, Vol 3, Iss 1 (2019)
Externí odkaz:
https://doaj.org/article/7dbadbb6e16d43a69d79dce4016c47f0
Autor:
Marcela A. Ferrada, Sinisa Savic, Daniela Ospina Cardona, Jason C. Collins, Hugh Alessi, Fernanda Gutierrez-Rodrigues, Dinesh Babu Uthaya Kumar, Lorena Wilson, Wendy Goodspeed, James S. Topilow, Julie J. Paik, James A. Poulter, Tanaz A. Kermani, Matthew J. Koster, Kenneth J. Warrington, Catherine Cargo, Rachel S. Tattersall, Christopher J. A. Duncan, Anna Cantor, Patrycja Hoffmann, Elspeth M. Payne, Hanna Bonnekoh, Karoline Krause, Edward W. Cowen, Katherine R. Calvo, Bhavisha A. Patel, Amanda K. Ombrello, Daniel L. Kastner, Neal S. Young, Achim Werner, Peter C. Grayson, David B. Beck
Somatic mutations in UBA1 cause vacuoles, E1 ubiquitin-activating enzyme, X-linked, autoinflammatory somatic (VEXAS) syndrome, an adult-onset inflammatory disease with an overlap of hematologic manifestations. VEXAS syndrome is characterized by a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8c674df36e5d2fbb8743262ff01d7b
https://eprints.whiterose.ac.uk/191042/1/106414_1_merged_1656075092.pdf
https://eprints.whiterose.ac.uk/191042/1/106414_1_merged_1656075092.pdf
Publikováno v:
Advances in Hematology, Vol 2012 (2012)
Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements
Externí odkaz:
https://doaj.org/article/809e7e1945904c2d95c5499dbdcb067e
Autor:
Chin‐Hin Ng, Dima El-Sharkawi, Rakesh Popat, Elspeth M. Payne, Asim Khwaja, Kirit M. Ardeshna, William Townsend, Kwee Yong
Publikováno v:
British Journal of Haematology. 185:344-347
Phase I clinical trials are primarily designed to assess the safety and toxicity of a new agent and determine the recommended dose for further trials that assess efficacy. Patients entering these trials typically have multiply relapsed or refractory
Autor:
Kwee Yong, Asim Khwaja, Elspeth M. Payne, Dima El-Sharkawi, Kirit M. Ardeshna, Rakesh Popat, Chin-Hin Ng
Publikováno v:
Blood. 128:3613-3613
Introduction: Phase I clinical trials are primarily designed to assess the safety and toxicity of a new agent and determine the recommended dose. Such trials are challenging as patients typically have multiply relapsed/ refractory disease and have re
Autor:
Rachel E. Sutton, Francesco Ferraro, Michael Laffan, Daniel F. Cutler, Dorian O. Haskard, Alun D. Hughes, Elspeth M. Payne, Nicola H. Dryden, Richard D. Starke, Anna M. Randi, Koralia E. Paschalaki, Thomas A. J. McKinnon
Publikováno v:
Vascular Pharmacology. 56:318-319
The regulation of blood vessel formation is of fundamental importance to many physiological processes, and angiogenesis is a major area for novel therapeutic approaches to diseases from ischemia to cancer. A poorly understood clinical manifestation o