Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Elspeth F, Garman"'
Publikováno v:
IUCrJ, Vol 10, Iss 4, Pp 377-379 (2023)
This editorial acknowledges the transformative impact of new machine-learning methods, such as the use of AlphaFold, but also makes the case for the continuing need for experimental structural biology.
Externí odkaz:
https://doaj.org/article/08110045186d4245962bb14f4413bfb6
Autor:
Kathryn L. Shelley, Elspeth F. Garman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Radiation damage hampers protein structure determination by X-ray crystallography. Here, the AUs introduce the B net metric, a single value summarising the extent of radiation damage of a protein crystal structure, and use B net to detect radiation d
Externí odkaz:
https://doaj.org/article/d78b9a058c394595a8a1d93af0d1cec7
Autor:
Robert J. Ragotte, David Pulido, Amelia M. Lias, Doris Quinkert, Daniel G. W. Alanine, Abhishek Jamwal, Hannah Davies, Adéla Nacer, Edward D. Lowe, Geoffrey W. Grime, Joseph J. Illingworth, Robert F. Donat, Elspeth F. Garman, Paul W. Bowyer, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Antibodies can have synergistic effects, but mechanisms are not well understood. Here, Ragotte et al. identify three antibodies that bind neighbouring epitopes on CyRPA, a malaria vaccine candidate, and show that lateral interactions between the anti
Externí odkaz:
https://doaj.org/article/311198660694450bbebda7b48bd4d1b2
Autor:
Geoffrey W. Grime, Elspeth F. Garman
Publikováno v:
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 540:237-245
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49add9a6d85b6c7e23d8579fbf266646
https://doi.org/10.1016/j.nimb.2023.03.025
https://doi.org/10.1016/j.nimb.2023.03.025
Autor:
Edward N. Baker, Charles S. Bond, Elspeth F. Garman, Janet Newman, Randy J. Read, Mark J. van Raaij
Publikováno v:
IUCrJ, Vol 9, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/0128d5448fcd4b7bb2c12851760a7418
Autor:
Jeppe Christensen, Peter N. Horton, Charles S. Bury, Joshua L. Dickerson, Helena Taberman, Elspeth F. Garman, Simon J. Coles
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 703-713 (2019)
Traditionally small-molecule crystallographers have not usually observed or recognized significant radiation damage to their samples during diffraction experiments. However, the increased flux densities provided by third-generation synchrotrons have
Externí odkaz:
https://doaj.org/article/e36d7fd75fb84608a740773feee17ff9
Autor:
John R. Helliwell, Wladek Minor, Manfred S. Weiss, Elspeth F. Garman, Randy J. Read, Janet Newman, Mark J. van Raaij, Janos Hajdu, Edward N. Baker
Publikováno v:
IUCrJ, Vol 6, Iss 3, Pp 341-343 (2019)
Externí odkaz:
https://doaj.org/article/abdf3270f7b24633a2f882b6f9229ab7
Publikováno v:
Acta Crystallographica Section D Structural Biology. 79:95-97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c58dea428c47592843bc3f96bf46838
https://doi.org/10.1107/s2059798323001006
https://doi.org/10.1107/s2059798323001006
Autor:
Mark D. White, Maria Klecker, Richard J. Hopkinson, Daan A. Weits, Carolin Mueller, Christin Naumann, Rebecca O’Neill, James Wickens, Jiayu Yang, Jonathan C. Brooks-Bartlett, Elspeth F. Garman, Tom N. Grossmann, Nico Dissmeyer, Emily Flashman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The N-end rule pathway targets substrate proteins for proteasomal degradation. Here, Whiteet al. show that ArabidopsisPLANT CYSTEINE OXIDASEs show dioxygenase activity producing Cys-sulfinic acid at the N-terminus of target proteins, which then act a
Externí odkaz:
https://doaj.org/article/208c41197c3f40509bc868b20218a21a
Autor:
Martin Weik, Elspeth F. Garman
Publikováno v:
Journal of Synchrotron Radiation
An understanding of radiation damage effects suffered by biological samples during structural analysis using both X-rays and electrons is pivotal to obtain reliable molecular models of imaged molecules. This special issue on radiation damage contains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976b07b751c7f1c0b9e982cb164fd3ce
https://doi.org/10.1107/s1600577521008845
https://doi.org/10.1107/s1600577521008845