The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study

Autor: Marie R. Vermeiren, Joost Somsen, Gert Luurtsema, Fransje E. Reesink, Nicolaas A. Verwey, Liesbeth Hempenius, Nelleke Tolboom, Geert Jan Biessels, J. Matthijs Biesbroek, Meike W. Vernooij, Sophie E. M. Veldhuijzen van Zanten, Harro Seelaar, Emma M. Coomans, Charlotte E. Teunissen, Afina W. Lemstra, Argonde C. van Harten, Leonie N. C. Visser, Wiesje M. van der Flier, Elsmarieke van de Giessen, Rik Ossenkoppele

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)

Abstract Background Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer’s disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in real

Externí odkaz: https://doaj.org/article/d3a59bc2cf6d4922a76611eb0bd5f947

Digital remote assessment of speech acoustics in cognitively unimpaired adults: feasibility, reliability and associations with amyloid pathology

Autor: Rosanne L. van den Berg, Casper de Boer, Marissa D. Zwan, Roos J. Jutten, Mariska van Liere, Marie-Christine A.B.J. van de Glind, Mark A. Dubbelman, Lisa Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Frederik Barkhof, Lyduine E. Collij, Jessica Robin, William Simpson, John E Harrison, Wiesje M. van der Flier, Sietske A.M. Sikkes

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)

Abstract Background Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer’s disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (Aβ) patholo

Externí odkaz: https://doaj.org/article/75ea7ee6329e4654a1896779b7cc2a38

Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population

Autor: Lyduine E. Collij, Gill Farrar, Marissa Zwan, Elsmarieke van de Giessen, Rik Ossenkoppele, Frederik Barkhof, Annemieke J. M. Rozemuller, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Femke Bouwman

Publikováno v: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-10 (2023)

Abstract Background Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. However, studies investigating longitudinal outcomes over an extended period of time are limited. Therefore, we a

Externí odkaz: https://doaj.org/article/9ccb9c1fcbc94c9aaed34a13510d738f

Computerized decision support is an effective approach to select memory clinic patients for amyloid-PET.

Autor: Hanneke F M Rhodius-Meester, Ingrid S van Maurik, Lyduine E Collij, Aniek M van Gils, Juha Koikkalainen, Antti Tolonen, Yolande A L Pijnenburg, Johannes Berkhof, Frederik Barkhof, Elsmarieke van de Giessen, Jyrki Lötjönen, Wiesje M van der Flier

Publikováno v: PLoS ONE, Vol 19, Iss 5, p e0303111 (2024)

BackgroundThe use of amyloid-PET in dementia workup is upcoming. At the same time, amyloid-PET is costly and limitedly available. While the appropriate use criteria (AUC) aim for optimal use of amyloid-PET, their limited sensitivity hinders the trans

Externí odkaz: https://doaj.org/article/3ee1ec89908740e789f246a71d9f7bfa

Tau pathology as determinant of changes in atrophy and cerebral blood flow

Autor: Denise Visser, Sander C. J. Verfaillie, Iris Bosch, Iman Brouwer, Hayel Tuncel, Emma M. Coomans, Roos M. Rikken, Sophie E. Mastenbroek, Sandeep S. V. Golla, Frederik Barkhof, Elsmarieke van de Giessen, Bart N. M. van Berckel, Wiesje M. van der Flier, Rik Ossenkoppele

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 50(8), 2409-2419. Springer Verlag
Visser, D, Verfaillie, S C J, Bosch, I, Brouwer, I, Tuncel, H, Coomans, E M, Rikken, R M, Mastenbroek, S E, Golla, S S V, Barkhof, F, van de Giessen, E, van Berckel, B N M, van der Flier, W M & Ossenkoppele, R 2023, ' Tau pathology as determinant of changes in atrophy and cerebral blood flow : a multi-modal longitudinal imaging study ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 50, no. 8, pp. 2409-2419 . https://doi.org/10.1007/s00259-023-06196-2

Purpose Tau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer’s disease (AD), but less is known about their temporal relationships. Our aim was therefore to investigate the association of concurren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59aaf4513d266a4438b0d9a124af4e9
https://doi.org/10.1007/s00259-023-06196-2