The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents.

Autor: Keuler T; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Lemke C; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Elsinghorst PW; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.; Central Institute of the Bundeswehr Medical Service Munich, Ingolstädter Landstraße 102, 85748 Garching Germany., Iriepa I; Universidad de Alcalá, Departamento de Química Orgánica y Química Inorgánica, Ctra. Madrid-Barcelona, 28871 Alcalá de Henares, Madrid España., Chioua M; Laboratory of Medicinal Chemistry, IQOG, CSIC, C/Juan de la Cierva 3, 28006 Madrid, Spain., Martínez-Grau MA; Lilly Research Laboratories, Eli Lilly & Company, Avda. de la Industria 30, 28108 Alcobendas, Madrid Spain., Beadle CD; Lilly Research Centre, Eli Lilly & Company, Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom., Vetman T; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285, United States., López-Muñoz F; Faculty of Health, Camilo José Cela University of Madrid (UCJC), Neuropsychopharmacology Unit, 'Hospital 12 de Octubre' Research Institute, 28692 Madrid, Spain., Wille T; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937 München, Germany., Bartz U; Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, von-Liebig-Straße 20, 53359 Rheinbach, Germany., Deuther-Conrad W; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany., Marco-Contelles J; Laboratory of Medicinal Chemistry, IQOG, CSIC, C/Juan de la Cierva 3, 28006 Madrid, Spain., Gütschow M; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2022 Oct 12; Vol. 5 (11), pp. 1097-1108. Date of Electronic Publication: 2022 Oct 12 (Print Publication: 2022).

Guiding Molecularly Imprinted Polymer Design by Pharmacophore Modeling.

Autor: Derz W; Central Institute of the Bundeswehr Medical Service Munich, 85748 Garching, Germany.; Institute of Nutrition and Food Sciences, University of Bonn, 53115 Bonn, Germany., Fleischmann M; Central Institute of the Bundeswehr Medical Service Munich, 85748 Garching, Germany.; Food Technology & Nutrition, Management Center Innsbruck, 6020 Innsbruck, Austria., Elsinghorst PW; Central Institute of the Bundeswehr Medical Service Munich, 85748 Garching, Germany.; Institute of Nutrition and Food Sciences, University of Bonn, 53115 Bonn, Germany.; Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, 53121 Bonn, Germany.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Aug 23; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 23.

Chromenones as Multineurotargeting Inhibitors of Human Enzymes.

Autor: Lemke C; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Christmann J; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937 München, Germany., Yin J; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Alonso JM; Laboratory of Medicinal Chemistry, IQOG, CSIC, C/Juan de la Cierva 3, 28006 Madrid, Spain., Serrano E; Laboratory of Medicinal Chemistry, IQOG, CSIC, C/Juan de la Cierva 3, 28006 Madrid, Spain., Chioua M; Laboratory of Medicinal Chemistry, IQOG, CSIC, C/Juan de la Cierva 3, 28006 Madrid, Spain., Ismaili L; Neurosciences intégratives et cliniques EA 481, Pôle de Chimie Organique et Thérapeutique, Univ. Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, 25000 Besançon, France., Martínez-Grau MA; Lilly Research Laboratories, Eli Lilly & Company, Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain., Beadle CD; Lilly Research Centre, Eli Lilly & Company, Erl Wood Manor, Windlesham, Surrey GU20 6PH, U.K., Vetman T; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis 46285, Indiana, United States., Dato FM; Institute II of Pharmacology, Center of Pharmacology, Medical Faculty, University of Cologne, Gleueler Strasse 24, 50931 Cologne, Germany., Bartz U; Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, von-Liebig-Strasse 20, 53359 Rheinbach, Germany., Elsinghorst PW; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.; Central Institute of the Bundeswehr Medical Service Munich, Ingolstädter Landstraße 102, 85748 Garching, Germany., Pietsch M; Institute II of Pharmacology, Center of Pharmacology, Medical Faculty, University of Cologne, Gleueler Strasse 24, 50931 Cologne, Germany., Müller CE; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Iriepa I; Department of Organic and Inorganic Chemistry, University of Alcalá, Ctra. Madrid-Barcelona, Km. 33,6, 28871 Alcalá de Henares, Madrid, Spain., Wille T; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937 München, Germany., Marco-Contelles J; Laboratory of Medicinal Chemistry, IQOG, CSIC, C/Juan de la Cierva 3, 28006 Madrid, Spain., Gütschow M; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

Publikováno v: ACS omega [ACS Omega] 2019 Dec 11; Vol. 4 (26), pp. 22161-22168. Date of Electronic Publication: 2019 Dec 11 (Print Publication: 2019).

Optimized Analysis of Ergot Alkaloids in Rye Products by Liquid Chromatography-Fluorescence Detection Applying Lysergic Acid Diethylamide as an Internal Standard.

Autor: Holderied I; Central Institute of the Bundeswehr Medical Service Munich, Ingolstädter Landstraße 102, D-85748 Garching, Germany.; Chair of Analytical Food Chemistry, Technical University of Munich, Maximus-von-Imhof-Forum 2, D-85350 Freising, Germany., Rychlik M; Chair of Analytical Food Chemistry, Technical University of Munich, Maximus-von-Imhof-Forum 2, D-85350 Freising, Germany., Elsinghorst PW; Central Institute of the Bundeswehr Medical Service Munich, Ingolstädter Landstraße 102, D-85748 Garching, Germany. paulelsinghorst@bundeswehr.org.; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany. paulelsinghorst@bundeswehr.org.

Publikováno v: Toxins [Toxins (Basel)] 2019 Mar 28; Vol. 11 (4). Date of Electronic Publication: 2019 Mar 28.

Identification of novel disulfide adducts between the thiol containing leaving group of the nerve agent VX and cysteine containing tripeptides derived from human serum albumin.

Autor: Kranawetvogl A; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany., Küppers J; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Gütschow M; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany., Thiermann H; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany., Elsinghorst PW; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.; Central Institute of the Bundeswehr Medical Service Munich, Ingolstädter Landstrasse 102, 85748, Garching, Germany., John H; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany.

Publikováno v: Drug testing and analysis [Drug Test Anal] 2017 Aug; Vol. 9 (8), pp. 1192-1203. Date of Electronic Publication: 2017 Mar 03.