Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function.

Autor: Barden M; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Elsenbroich PR; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Haas V; Institute for Drug Discovery, Leipzig University Faculty of Medicine, Leipzig, Germany., Ertelt M; Institute for Drug Discovery, Leipzig University Faculty of Medicine, Leipzig, Germany.; Center for Scalable Data Analytics and Artificial Intelligence, ScaDS.AI, Dresden/Leipzig, Germany., Pervan P; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Velas L; Institute of Applied Physics, TU Wien, Vienna, Austria., Gergely B; Department of Biophysics and Cell Biology, University of Debrecen Faculty of Medicine, Debrecen, Hungary., Szöőr Á; Department of Biophysics and Cell Biology, University of Debrecen Faculty of Medicine, Debrecen, Hungary., Harrer DC; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Bezler V; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Holzinger A; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Friis RUW; Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark., Vereb G; Biophysics and Cell Biology, University of Debrecen, Debrecen, Hungary., Schütz GJ; Institute of Applied Physics, TU Wien, Vienna, Austria., Schoeder CT; Institute for Drug Discovery, Leipzig University Faculty of Medicine, Leipzig, Germany.; Center for Scalable Data Analytics and Artificial Intelligence, ScaDS.AI, Dresden/Leipzig, Germany.; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany., Hombach AA; Department I Internal Medicine, University Hospital Cologne, and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Abken H; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany hinrich.abken@ukr.de.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Dec 02; Vol. 12 (12). Date of Electronic Publication: 2024 Dec 02.