Detection of Noncovalent Protein-Ligand Complexes by IR-MALDESI-MS.

Autor: Knizner KT; FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States., Pu F; Discovery Research, AbbVie Inc., North Chicago, Illinois 60064, United States., Sawicki JW; Discovery Research, AbbVie Inc., North Chicago, Illinois 60064, United States., Radosevich AJ; Discovery Research, AbbVie Inc., North Chicago, Illinois 60064, United States., Ugrin SA; Discovery Research, AbbVie Inc., North Chicago, Illinois 60064, United States., Elsen NL; Discovery Research, AbbVie Inc., North Chicago, Illinois 60064, United States., Williams JD; Discovery Research, AbbVie Inc., North Chicago, Illinois 60064, United States., Muddiman DC; FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.

Publikováno v: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2024 Aug 07; Vol. 35 (8), pp. 1913-1920. Date of Electronic Publication: 2024 Jul 11.

Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma.

Autor: Plotnik JP; AbbVie Inc., North Chicago, Illinois., Richardson AE; AbbVie Inc., North Chicago, Illinois., Yang H; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Rojas E; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Bontcheva V; AbbVie Inc., North Chicago, Illinois., Dowell C; AbbVie Inc., North Chicago, Illinois., Parsons S; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Wilson A; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Ravanmehr V; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Will C; AbbVie Inc., North Chicago, Illinois., Jung P; AbbVie Inc., North Chicago, Illinois., Zhu H; AbbVie Inc., North Chicago, Illinois., Partha SK; AbbVie Inc., North Chicago, Illinois., Panchal SC; AbbVie Inc., North Chicago, Illinois., Mali RS; AbbVie Bay Area, South San Francisco, California., Kohlhapp FJ; AbbVie Inc., North Chicago, Illinois., McClure RA; AbbVie Inc., North Chicago, Illinois., Ramathal CY; AbbVie Inc., North Chicago, Illinois., George MD; AbbVie Inc., North Chicago, Illinois., Jhala M; AbbVie Inc., North Chicago, Illinois., Elsen NL; AbbVie Inc., North Chicago, Illinois., Qiu W; AbbVie Inc., North Chicago, Illinois., Judge RA; AbbVie Inc., North Chicago, Illinois., Pan C; AbbVie Bay Area, South San Francisco, California., Mastracchio A; AbbVie Inc., North Chicago, Illinois., Henderson J; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Meulbroek JA; AbbVie Inc., North Chicago, Illinois., Green MR; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Pappano WN; AbbVie Inc., North Chicago, Illinois.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2024 Jul 02; Vol. 23 (7), pp. 949-960.

New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry.

Autor: Pu F; Discovery Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Radosevich AJ; Discovery Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Bruckner BG; Discovery Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Fontaine DA; Discovery Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Panchal SC; Discovery Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Williams JD; Discovery Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Gopalakrishnan SM; Discovery Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Elsen NL; Discovery Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, Illinois 60064, United States.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2023 Apr 21; Vol. 18 (4), pp. 942-948. Date of Electronic Publication: 2023 Apr 12.

Next-Generation Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Source for Mass Spectrometry Imaging and High-Throughput Screening.

Autor: Knizner KT; FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States., Guymon JP; Precision Engineering Consortium, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States., Garrard KP; FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.; Precision Engineering Consortium, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States.; Molecular Education, Technology and Research Innovation Center (METRIC), North Carolina State University, Raleigh, North Carolina 27695, United States., Bouvrée G; GB Conseil & Services, 77170 Brie Comte Robert, France., Manni J; JGM Associates, Inc., Burlington, Massachusetts 01803, United States., Hauschild JP; Thermo Fisher Scientific (Bremen) GmbH, 28199 Bremen, Germany., Strupat K; Thermo Fisher Scientific (Bremen) GmbH, 28199 Bremen, Germany., Fort KL; Thermo Fisher Scientific (Bremen) GmbH, 28199 Bremen, Germany., Earley L; Thermo Fisher Scientific, San Jose, California 95134, United States., Wouters ER; Thermo Fisher Scientific, San Jose, California 95134, United States., Pu F; Drug Discovery Science and Technology, AbbVie Inc., North Chicago, Illinois 60064, United States., Radosevich AJ; Drug Discovery Science and Technology, AbbVie Inc., North Chicago, Illinois 60064, United States., Elsen NL; Drug Discovery Science and Technology, AbbVie Inc., North Chicago, Illinois 60064, United States., Williams JD; Drug Discovery Science and Technology, AbbVie Inc., North Chicago, Illinois 60064, United States., Pankow MR; Precision Engineering Consortium, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States., Muddiman DC; FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.; Molecular Education, Technology and Research Innovation Center (METRIC), North Carolina State University, Raleigh, North Carolina 27695, United States.

Publikováno v: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2022 Nov 02; Vol. 33 (11), pp. 2070-2077. Date of Electronic Publication: 2022 Sep 29.

Normalization techniques for high-throughput screening by infrared matrix-assisted laser desorption electrospray ionization mass spectrometry.

Autor: Knizner KT; FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA., Bagley MC; FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA., Pu F; Drug Discovery Science and Technology, AbbVie Inc., North Chicago, Illinois, USA., Elsen NL; Drug Discovery Science and Technology, AbbVie Inc., North Chicago, Illinois, USA., Williams JD; Drug Discovery Science and Technology, AbbVie Inc., North Chicago, Illinois, USA., Muddiman DC; FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.; Molecular Education, Technology and Research Innovation Center (METRIC), North Carolina State University, Raleigh, North Carolina, USA.

Publikováno v: Journal of mass spectrometry : JMS [J Mass Spectrom] 2022 Jun; Vol. 57 (6), pp. e4869.