Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments.

Autor: Elsebaie HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt., Abdulla MH; Colorectal Research Chair, Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address: mahaa.hamadien@gmail.com., Elsayed ZM; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt., Shaldam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt., Tawfik HO; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt. Electronic address: haytham.omar.mahmoud@pharm.tanta.edu.eg., Morsy SN; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt., Vaali Mohammed MA; Colorectal Research Chair, Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Bin Traiki T; Colorectal Research Chair, Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo 12622, Egypt., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia St., Alexandria 21648, Egypt. Electronic address: wagdy2000@gmail.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Oct; Vol. 151, pp. 107626. Date of Electronic Publication: 2024 Jul 10.

Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in silico studies.

Autor: Elsebaie HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University Tanta 31527 Egypt haytham.omar.mahmoud@pharm.tanta.edu.eg., Nafie MS; Department of Chemistry, College of Sciences, University of Sharjah Sharjah 27272 United Arab Emirates.; Chemistry Department, Faculty of Science, Suez Canal University Ismailia 41522 Egypt., Tawfik HO; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University Tanta 31527 Egypt haytham.omar.mahmoud@pharm.tanta.edu.eg.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AlSalam University in Egypt Kafr Al Zaiyat 6615062 Egypt., Belal A; Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University P.O. Box 11099 Taif 21944 Saudi Arabia., Ghoneim MM; Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University Ad Diriyah Riyadh 13713 Saudi Arabia., Obaidullah AJ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia., Shaaban S; Department of Microbiology & Immunology, Faculty of pharmacySuef University Beni-Suef Egypt.; Department of Clinical Laboratory Sciences, Faculty of Applied medical Sciences, King Khalid University Abha Saudi Arabia., Ayed AA; Department of Chemistry, Faculty of Science, Cairo University Giza Cairo 12613 Egypt., El-Naggar M; Chemistry department, Faculty of Sciences, Pure and Applied Chemistry Group, University of Sharjah P. O. Box 27272 Sharjah United Arab Emirates., Mehany ABM; Zoology Department, Faculty of Science (Boys), Al-Azhar University Cairo 11884 Egypt., Shaldam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AlSalam University in Egypt Kafr Al Zaiyat 6615062 Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University P.O. Box 33516 Kafrelsheikh Egypt dr_moutaz_986@pharm.kfs.edu.eg.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2024 Jun 12; Vol. 15 (7), pp. 2553-2569. Date of Electronic Publication: 2024 Jun 12 (Print Publication: 2024).

Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights.

Autor: Elsebaie HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527 Egypt. Electronic address: heba.nseer@pharm.tanta.edu.eg., El-Bastawissy EA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527 Egypt. Electronic address: emanesmat@pharm.tanta.edu.eg., Elberembally KM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527 Egypt. Electronic address: kamel.mohamed@pharm.tanta.edu.eg., Khaleel EF; Department of Medical Physiology, College of Medicine, King Khalid University, King Khalid University, Asir 61421, Saudi Arabia. Electronic address: eman_4000@hotmail.com., Badi RM; Department of Medical Physiology, College of Medicine, King Khalid University, King Khalid University, Asir 61421, Saudi Arabia. Electronic address: rbadi@kku.edu.sa., Shaldam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt. Electronic address: dr_moutaz_986@pharm.kfs.edu.eg., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt; School of Biotechnology, Badr University in Cairo, Badr City 11829, Egypt. Electronic address: wagdy2000@gmail.com., Tawfik HO; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527 Egypt. Electronic address: haytham.omar.mahmoud@pharm.tanta.edu.eg., El-Moselhy TF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527 Egypt. Electronic address: tarek.faathy@pharm.tanta.edu.eg.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2023 Nov; Vol. 140, pp. 106799. Date of Electronic Publication: 2023 Aug 22.