Safety, Feasibility, and Potential Clinical Efficacy of 40 Hz Invisible Spectral Flicker versus Placebo in Patients with Mild-to-Moderate Alzheimer’s Disease: A Randomized, Placebo-Controlled, Double-Blinded, Pilot Study

Autor: Mikkel Pejstrup Agger, Else Rubæk Danielsen, Marcus Schultz Carstensen, N. Mai Nguyen, Maibritt Horning, Mark Alexander Henney, Christopher Boe Ravn Jensen, Anders Ohlhues Baandrup, Troels Wesenberg Kjær, Kristoffer Hougaard Madsen, Kamilla Miskowiak, Paul Michael Petersen, Peter Høgh

Publikováno v: Agger, M P, Danielsen, E R, Carstensen, M S, Nguyen, N M, Horning, M, Henney, M A, Jensen, C B R, Baandrup, A O, Kjaer, T W, Madsen, K H, Miskowiak, K W, Petersen, P M & Høgh, P 2023, ' Safety, Feasibility, and Potential Clinical Efficacy of 40 Hz Invisible Spectral Flicker versus Placebo in Patients with Mild-to-Moderate Alzheimer’s Disease : A Randomized, Placebo-Controlled, Double-Blinded, Pilot Study ', Journal of Alzheimer's Disease, vol. 92, no. 2, pp. 653-665 . https://doi.org/10.3233/JAD-221238

Background: Recent studies suggested induction of 40 Hz neural activity as a potential treatment for Alzheimer’s disease (AD). However, prolonged exposure to flickering light raises adherence and safety concerns, encouraging investigation of tolera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a562e9f39e60247fad7997f1361a01ce
https://doi.org/10.3233/jad-221238

Outcome of accidental hypothermia with or without circulatory arrest

Autor: Jesper Ravn, Lisbeth Agersnap, Anne Grethe Lorentzen, Michael Wanscher, Christian Hassager, Bertil Romner, Steen Barnung, Jacob E. Møller, Carsten Thomsen, Jørgen Feldbæk Nielsen, Else Rubæk Danielsen, Matthew Davis, Hans Høgenhaven, Stig Yndgaard

Publikováno v: Resuscitation. 83:1078-1084

Background Resuscitation guidelines for the treatment of accidental hypothermia are based primarily on isolated cases. Mortality rates are high despite aggressive treatment aimed at restoring spontaneous circulation and normothermia. Methods The pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cccdb57b381aa9e885087a20a2f4134
https://doi.org/10.1016/j.resuscitation.2012.05.009

Good outcome after posterior reversible encephalopathy syndrome (PRES) despite elevated cerebral lactate: a case report

Autor: Daniel Kondziella, Carsten Thomsen, Else Rubæk Danielsen, Caroline Ewertsen

Publikováno v: Acta Radiologica Open

Posterior reversible encephalopathy syndrome (PRES) may cause irreversible brain damage. The diagnosis is confirmed by magnetic resonance imaging (MRI), where vasogenic edema may be seen especially in the posterior parts of the brain. MR spectroscopy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ec793e12be368f0baf093c11306fe0
http://europepmc.org/articles/PMC4548744

In vivo magnetic resonance spectroscopy of human brain: The biophysical basis of dementia

Autor: Stefan Bluml, Robert Cowan, Brian D. Ross, Neil Farrow, Else Rubæk Danielsen, Rolf Gruetter

Publikováno v: Biophysical Chemistry. 68:161-172

Nuclear magnetic resonance spectroscopy (MRS) in low and medium magnetic fields yields well-resolved natural abundance proton and decoupled phosphorus spectra from small (1-10 cc) volumes of brain in vivo in minutes. With this tool, neurochemical res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678e563ccb7e6a91ec1ce41ad504bf47
https://doi.org/10.1016/s0301-4622(97)00032-x

CYP7B1: novel mutations and magnetic resonance spectroscopy abnormalities in hereditary spastic paraplegia type 5A

Autor: Jørgen E. Nielsen, Kirsten Svenstrup, Peter Roos, Else Rubæk Danielsen, Carsten Thomsen

Publikováno v: Acta neurologica Scandinavica. 129(5)

The SPG5A subtype of Hereditary Spastic Paraplegia (HSP) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the CYP7B1 gene, which encodes a steroid cytochrome P450 7α-hydroxylase. This enzyme provides the primary metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec44254104cbdf45ec5465a21a001ab
https://pubmed.ncbi.nlm.nih.gov/24117163