Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Else Marie Nicolaisen"'
Autor:
Else Marie Nicolaisen, Rupa S. Appa, Charlotte Theill, Carsten Behrens, Niels Kristian Klausen, Judi Møss, Lene Hansen, Michael S. Christensen
Publikováno v:
Thrombosis and Haemostasis. 104:243-251
SummaryClearance mechanisms for recombinant activated human FVII (rFVIIa; NovoSeven®), a heterogeneously glycosylated protein, have yet to be fully elucidated, but may involve the liver. The effects of the γ-carboxy glutamic acid (Gla) domain and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d168cf804f19db109236e1bfbcd97ae
https://doi.org/10.1160/th09-10-0723
https://doi.org/10.1160/th09-10-0723
Publikováno v:
University of Copenhagen
SummaryRecombinant human FVIIa (rFVIIa) was inactivated by coupling Phe-Phe-Arg-CO- (FFR) covalently to the active site of the enzyme. To test the chemically-modified human protein for potential antigenicity prior to clinical trial an immune-tolerant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1f04a8776ece36afafe22987540881
https://doi.org/10.1055/s-0037-1613093
https://doi.org/10.1055/s-0037-1613093
Autor:
Eric Camerer, H. Johnsson, Andreas Killander, Lochie Teague, James H. Morrissey, Mette Holm, Jan Erik Johansson, Erik Hippe, M. Shuman, Johan Stenflo, Royce Robinson Lawler, A. Yoshioka, Josiah N. Wilcox, Jen-Yea Chang, Leping Li, J. McPherson, Lee G. Pedersen, K. Nishio, Tom Darden, Paul Ockelford, Debra H. Allen, Sture Forsén, Lars C. Petersen, Stephen R. Hanson, Jörgen Kristensen, Vijaya Mohan Rao, E. Scheibel, Maria Sunnerhagen, Barbara C. Furie, J. Ingerslev, John V. Lloyd, Egon Persson, Carsten Helleberg, E.G.D. Tuddenham, Nigel Mackman, Elaine Gray, Kenneth A. Bauer, D. Freidman, Laurence A. Harker, Fletcher B. Taylor, Alison Street, N. Ciavarella, Hans Prydz, Jörgen Ellegård, Stephen Thomas, Ulla Hedner, Harold R. Roberts, Jean McPherson, K.M. Rice, Amy D. Shapiro, Stephen Poole, G. Gilchrist, Richard G. Hiskey, Dougald M. Monroe, Amanda Faase, F. Inchingolo, Steven Glazer, R. Mølskov Bech, Else Marie Nicolaisen, Laura A. Worfolk, Henry Ekert, Pier Mannuccio Mannucci, Maureane Hoffman, Sabine Eichinger, Torben Lund-Hansen, Jeanne M. Lusher, G. Lucas, Midori Shima, Paula B. Tracy, D. Gastineau, Samuel I. Rapaport, Ulf-Henrik Mellqvist, E. Preston, David Jupe, Robert D. Rosenberg, J. Rowell, F. Mangini, Yogesh Mistry, M. Schiavoni, Andrew B. Kelly, E. Valenzano, Torbjörn Drakenberg, G.F. Savidge, Jack Kutti, Bruce Furie
Publikováno v:
Pathophysiology of Haemostasis and Thrombosis. 26:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70fa533b6e9db6f6d879b2e486f5350e
https://doi.org/10.1159/000217231
https://doi.org/10.1159/000217231
Publikováno v:
Thrombosis and Haemostasis. 76:200-204
SummaryPatients, receiving rFVIIa for treatment of bleeding disorders, have been followed for specific antibody formation. No antibodies against FVII were demonstrated in 170 patients, with hemophilia, or with acquired inhibitors to clotting factors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::027782240b0f2894ca4b254e691559a8
https://doi.org/10.1055/s-0038-1650554
https://doi.org/10.1055/s-0038-1650554
Autor:
Else Marie Nicolaisen
Publikováno v:
Pathophysiology of Haemostasis and Thrombosis. 26:98-101
Twenty-eight patients were followed up for potential specific antibody formation after repeated use of recombinant factor VIla (rFVIIa). The population included 27 patients with congenital bleeding disorders and 1 nonhemophiliac with an FVIII inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65992f9b45c2a1b07b01807d60c569e1
https://doi.org/10.1159/000217249
https://doi.org/10.1159/000217249
Autor:
Erik Halkjaer, Gitte Mandrup, Stephen Bayne, Lars Thim, Inger Mollerup, Else Marie Nicolaisen, Tony Jørgensen
Publikováno v:
Biotechnology and Bioengineering. 48:501-505
A reverse phase HPLC (RP-HPLC) method for analysis of recombinant factor VIIa (rFVIIa) has been developed. The method discriminates between different forms of recombinant FVII (rFVII). To obtain separation of these closely related molecules the metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1ca263d85183bd0fc59a2d2a1b42b3
https://doi.org/10.1002/bit.260480512
https://doi.org/10.1002/bit.260480512
Publikováno v:
Biological chemistry. 394(6)
Coagulation factor VIII is a glycosylated, non-covalent heterodimer consisting of a heavy chain (A1-A2-B domains) and a light chain (A3-C1-C2 domains). The association of the chains, and the stability and function of the dimer depend on the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69433c4ad4b1adc4366791bac18b8fac
https://pubmed.ncbi.nlm.nih.gov/23435097
https://pubmed.ncbi.nlm.nih.gov/23435097
Autor:
Jes Kristian Jacobsen, Else Marie Nicolaisen, Lars Thim, Per Franklin Nielsen, Ulla Hedner, Inger Mollerup, Tony Jørgensen
Publikováno v:
FEBS letters. 317(3)
The heavy chain of coagulation factor VII contains a serine esterase entity. A partial cleavage in the heavy chain occurs during purification and activation of the single-chain zymogen, presumably as a result of autolysis. Neutrophil cathepsin G init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a663c8b52cdae977cc72abc6c9fcf9e9
https://pubmed.ncbi.nlm.nih.gov/8425611
https://pubmed.ncbi.nlm.nih.gov/8425611
Autor:
Ulla Hedner, Mogens Christensen, Lars Thim, Else Marie Nicolaisen, Jes Kristian Jacobsen, Lars Christian Petersen
Publikováno v:
FEBS letters. 306(2-3)
Cougulation factor VII contains ten λ-carboxyglutamic acid residues in the N-terminal region (Gla-domain) which are essential for the hemostatic function of FVII. The present study shows that granulocyte cathepsin G degrades the Gla-domain of FVIIa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569a7d71d6845ed3e95a76b530fa0af9
https://pubmed.ncbi.nlm.nih.gov/1633870
https://pubmed.ncbi.nlm.nih.gov/1633870
Autor:
Eric Camerer, Maria Sunnerhagen, Barbara C. Furie, Lee G. Pedersen, F. Mangini, Jan Erik Johansson, Mette Holm, Jörgen Ellegård, J. Ingerslev, John Rowell, Laura A. Worfolk, Erik Hippe, Jean McPherson, Harold R. Roberts, E. Scheibel, Vijaya Mohan Rao, Henry Ekert, Johan Stenflo, M. Schiavoni, Amy D. Shapiro, Debra H. Allen, Royce Robinson Lawler, K.M. Rice, David Jupe, Else Marie Nicolaisen, Maureane Hoffman, Ulla Hedner, Nigel Mackman, Sture Forsén, J. McPherson, E.G.D. Tuddenham, Lars C. Petersen, Bruce Furie, Jörgen Kristensen, Paula B. Tracy, Dougald M. Monroe, Pier Mannuccio Mannucci, Josiah N. Wilcox, Andreas Killander, R. Mølskov Bech, Yogesh Mistry, Ulf-Henrik Mellqvist, Elaine Gray, D. Gastineau, Samuel I. Rapaport, James H. Morrissey, Carsten Helleberg, M. Shuman, G. Gilchrist, A. Yoshioka, E. Preston, Amanda Faase, F. Inchingolo, Kenneth A. Bauer, Robert D. Rosenberg, Steven Glazer, Stephen Poole, Torben Lund-Hansen, Paul Ockelford, Tom Darden, Andrew B. Kelly, Richard Hiskey, Jen-Yea Chang, Laurence A. Harker, N. Ciavarella, G. Lucas, Midori Shima, E. Valenzano, John Lloyd, K. Nishio, D. Freidman, Fletcher B. Taylor, Jeanne M. Lusher, Lochie Teague, H. Johnsson, Leping Li, Stephen R. Hanson, Stephen Thomas, Egon Persson, Sabine Eichinger, Torbjörn Drakenberg, Alison Street, G.F. Savidge, Jack Kutti, Hans Prydz
Publikováno v:
Pathophysiology of Haemostasis and Thrombosis. 26:166-166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e51d254e6e4bcb03d1306824e995654
https://doi.org/10.1159/000217262
https://doi.org/10.1159/000217262