Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elsayed Tharwat Tolba Mohamed"'
Autor:
Kevin Rychel, Justin Tan, Arjun Patel, Cameron Lamoureux, Ying Hefner, Richard Szubin, Josefin Johnsen, Elsayed Tharwat Tolba Mohamed, Patrick V. Phaneuf, Amitesh Anand, Connor A. Olson, Joon Ho Park, Anand V. Sastry, Laurence Yang, Adam M. Feist, Bernhard O. Palsson
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113105- (2023)
Summary: Relationships between the genome, transcriptome, and metabolome underlie all evolved phenotypes. However, it has proved difficult to elucidate these relationships because of the high number of variables measured. A recently developed data an
Externí odkaz:
https://doaj.org/article/3fa5f4f1b24a41dda13d125aac6d22b6
Autor:
Kevin Rychel, Justin Tan, Arjun Patel, Cameron Lamoureux, Ying Hefner, Richard Szubin, Josefin Johnsen, Elsayed Tharwat Tolba Mohamed, Patrick V. Phaneuf, Amitesh Anand, Connor A. Olson, Joon Ho Park, Anand V. Sastry, Laurence Yang, Adam M. Feist, Bernhard O. Palsson
SummaryRelationships between the genome, transcriptome, and metabolome underlie all evolved phenotypes. However, it has proved difficult to elucidate these relationships because of the high number of variables measured. A recently developed data anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5606d7d30bdd12286b00ca1584020b1b
https://doi.org/10.1101/2022.12.20.521246
https://doi.org/10.1101/2022.12.20.521246
Autor:
Jens Nielsen, Elsayed Tharwat Tolba Mohamed, Carl Malina, Yun Chen, Mohammad S. Radi, Adam M. Feist, Markus J. Herrgård, Yongjun Wei, Rui Pedro Gomes Pereira
Publikováno v:
Metabolic Engineering. 56:130-141
Improving the growth phenotypes of microbes in high product concentrations is an essential design objective in the development of robust cell factories. However, the limited knowledge regarding tolerance mechanisms makes rational design of such trait
Autor:
Adam M. Feist, Isaac Cann, Hemanshu Mundhada, Markus J. Herrgård, Elsayed Tharwat Tolba Mohamed, Roderick I. Mackie, Jenny Marie Landberg, Alex Toftgaard Nielsen
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-14 (2019)
Mohamed, E T T, Mundhada, H, Landberg, J M, Cann, I, Mackie, R I, Nielsen, A T, Herrgard, M J & Feist, A M 2019, ' Generation of an E. coli platform strain for improved sucrose utilization using adaptive laboratory evolution ', Microbial Cell Factories, vol. 18, 116 . https://doi.org/10.1186/s12934-019-1165-2
Microbial Cell Factories
Mohamed, E T T, Mundhada, H, Landberg, J M, Cann, I, Mackie, R I, Nielsen, A T, Herrgard, M J & Feist, A M 2019, ' Generation of an E. coli platform strain for improved sucrose utilization using adaptive laboratory evolution ', Microbial Cell Factories, vol. 18, 116 . https://doi.org/10.1186/s12934-019-1165-2
Microbial Cell Factories
Background Sucrose is an attractive industrial carbon source due to its abundance and the fact that it can be cheaply generated from sources such as sugarcane. However, only a few characterized Escherichia coli strains are able to metabolize sucrose,
Autor:
Mohammad S. Radi, Solange I. Mussatto, Elsayed Tharwat Tolba Mohamed, Zhijia Liu, Giuliano Dragone, Adam M. Feist
Publikováno v:
Liu, Z, Radi, M, Mohamed, E T T, Feist, A M, Dragone, G & Mussatto, S I 2021, ' Adaptive laboratory evolution of Rhodosporidium toruloides to inhibitors derived from lignocellulosic biomass and genetic variations behind evolution ', Bioresource Technology, vol. 333, 125171 . https://doi.org/10.1016/j.biortech.2021.125171
Using lignocellulosic biomass hydrolysate for the production of microbial lipids and carotenoids is still a challenge due to the poor tolerance of oleaginous yeasts to the inhibitors generated during biomass pretreatment. In this study, a strategy of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e9f64d73317f51d8524d88255d885b
https://orbit.dtu.dk/en/publications/09e78785-91f7-4a13-a0f5-f29da2ae18bc
https://orbit.dtu.dk/en/publications/09e78785-91f7-4a13-a0f5-f29da2ae18bc
Autor:
Adam M. Feist, Allison Z. Werner, Blake A. Simmons, Aindrila Mukhopadhyay, Christine A. Singer, Elsayed Tharwat Tolba Mohamed, Steven W. Singer, Manuel Rafael Jiménez-Díaz, Davinia Salvachúa, Gregg T. Beckham, Kiki Szostkiewicz, Mohammad S. Radi, Markus J. Herrgård, Thomas Eng
Publikováno v:
Metabolic Engineering Communications, Vol 11, Iss, Pp e00143-(2020)
Metabolic Engineering Communications
Mohamed, E T T, Werner, A Z, Salvachúa, D, Singer, C A, Szostkiewicz, K, Rafael Jiménez-Díaz, M, Eng, T, Radi, M S, Simmons, B A, Mukhopadhyay, A, Herrgård, M J, Singer, S W, Beckham, G T & Feist, A M 2020, ' Adaptive laboratory evolution of Pseudomonas putida KT2440 improves p-coumaric and ferulic acid catabolism and tolerance ', Metabolic Engineering Communications, vol. 11, e00143 . https://doi.org/10.1016/j.mec.2020.e00143
Metabolic Engineering Communications
Mohamed, E T T, Werner, A Z, Salvachúa, D, Singer, C A, Szostkiewicz, K, Rafael Jiménez-Díaz, M, Eng, T, Radi, M S, Simmons, B A, Mukhopadhyay, A, Herrgård, M J, Singer, S W, Beckham, G T & Feist, A M 2020, ' Adaptive laboratory evolution of Pseudomonas putida KT2440 improves p-coumaric and ferulic acid catabolism and tolerance ', Metabolic Engineering Communications, vol. 11, e00143 . https://doi.org/10.1016/j.mec.2020.e00143
Pseudomonas putida KT2440 is a promising bacterial chassis for the conversion of lignin-derived aromatic compound mixtures to biofuels and bioproducts. Despite the inherent robustness of this strain, further improvements to aromatic catabolism and to
Autor:
Rui Pedro Gomes Pereira, Adam M. Feist, Markus J. Herrgård, Mohammad S. Radi, Elsayed Tharwat Tolba Mohamed, Jens Nielsen, Yun Chen
Publikováno v:
Pereira, R, Mohamed, E T T, Radi, M S, Herrgård, M J, Feist, A M, Nielsen, J & Chen, Y 2020, ' Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 45, pp. 27954-27961 . https://doi.org/10.1073/pnas.2013044117
Toxicity from the external presence or internal production of compounds can reduce the growth and viability of microbial cell factories and compromise productivity. Aromatic compounds are generally toxic for microorganisms, which makes their producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f5575e8380cb7b3bce2eeba1357ca4
https://orbit.dtu.dk/en/publications/f66a0cf1-8088-44b0-a6c7-74b4735e00c9
https://orbit.dtu.dk/en/publications/f66a0cf1-8088-44b0-a6c7-74b4735e00c9
Autor:
Frank Stein, Tomas Strucko, Kiran Raosaheb Patil, Katharina Zirngibl, Adam M. Feist, Mandy Rettel, Filipa Pereira, Eleni Kafkia, Paula Jouhten, Jochen Förster, Elsayed Tharwat Tolba Mohamed
Publikováno v:
Strucko, T, Zirngibl, K, Pereira, F, Kafkia, E, Mohamed, E T, Rettel, M, Stein, F, Feist, A M, Jouhten, P, Patil, K R & Forster, J 2018, ' Laboratory evolution reveals regulatory and metabolic trade-offs of glycerol utilization in Saccharomyces cerevisiae ', Metabolic Engineering, vol. 47, pp. 73-82 . https://doi.org/10.1016/j.ymben.2018.03.006
Most microbial species, including model eukaryote Saccharomyces cerevisiae, possess genetic capability to utilize many alternative nutrient sources. Yet, it remains an open question whether these manifest into assimilatory phenotypes. Despite possess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fe1ee50ec36e85e01fbf455b458c19
https://orbit.dtu.dk/en/publications/0aa491a2-33ed-47fe-9519-f8675852207e
https://orbit.dtu.dk/en/publications/0aa491a2-33ed-47fe-9519-f8675852207e
Autor:
Rebecca Lennen, Alex Toftgaard Nielsen, Markus Herrgard, Morten Otto Alexander Sommer, Adam Feist, Elsayed Tharwat Tolba Mohamed
Publikováno v:
Lennen, R, Nielsen, A T, Herrgard, M, Sommer, M O A, Feist, A & Tharwat Tolba Mohamed, E, Bacterial cells with improved tolerance to diacids, Patent No. WO2018091525 .
Technical University of Denmark Orbit
Technical University of Denmark Orbit
The present invention relates to bacterial cells genetically modified to improve their tolerance to certain commodity chemicals, such as diacids, and to methods of preparing and using such bacterial cells for production of diacids and other compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::550db7689a2e7ebefc318b328584e921
https://orbit.dtu.dk/en/publications/a7055d68-2507-45cb-ac24-194053e21f44
https://orbit.dtu.dk/en/publications/a7055d68-2507-45cb-ac24-194053e21f44
Autor:
Elsayed Tharwat Tolba Mohamed, Blake A. Simmons, Markus J. Herrgård, Adam M. Feist, Steven W. Singer, Rebecca M. Lennen, Shizeng Wang
Publikováno v:
Microbial cell factories, vol 16, iss 1
Mohamed, E T, Wang, S, Lennen, R M, Herrgård, M J, Simmons, B A, Singer, S W & Feist, A M 2017, ' Generation of a platform strain for ionic liquid tolerance using adaptive laboratory evolution ', Microbial Cell Factories, vol. 16, no. 1, 204 . https://doi.org/10.1186/s12934-017-0819-1
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-15 (2017)
Mohamed, ET; Wang, S; Lennen, RM; Herrgård, MJ; Simmons, BA; Singer, SW; et al.(2017). Generation of a platform strain for ionic liquid tolerance using adaptive laboratory evolution. Microbial Cell Factories, 16(1). doi: 10.1186/s12934-017-0819-1. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/4473v9vd
Microbial Cell Factories
Mohamed, E T, Wang, S, Lennen, R M, Herrgård, M J, Simmons, B A, Singer, S W & Feist, A M 2017, ' Generation of a platform strain for ionic liquid tolerance using adaptive laboratory evolution ', Microbial Cell Factories, vol. 16, no. 1, 204 . https://doi.org/10.1186/s12934-017-0819-1
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-15 (2017)
Mohamed, ET; Wang, S; Lennen, RM; Herrgård, MJ; Simmons, BA; Singer, SW; et al.(2017). Generation of a platform strain for ionic liquid tolerance using adaptive laboratory evolution. Microbial Cell Factories, 16(1). doi: 10.1186/s12934-017-0819-1. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/4473v9vd
Microbial Cell Factories
Background There is a need to replace petroleum-derived with sustainable feedstocks for chemical production. Certain biomass feedstocks can meet this need as abundant, diverse, and renewable resources. Specific ionic liquids (ILs) can play a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65437be3ca74cb60160859e8d4945ea5
https://escholarship.org/uc/item/4473v9vd
https://escholarship.org/uc/item/4473v9vd