Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Elsa Moreno-Viguri"'
Autor:
Rocio Paucar-Bernabé, Rubén Martín-Escolano, Elsa Moreno-Viguri, Manuel Sánchez-Moreno, Silvia Pérez-Silanes
Publikováno v:
Proceedings, Vol 1, Iss 6, p 636 (2017)
Chagas disease and Leishmaniasis are trypanosomatid diseases considered as neglected tropical diseases by the WHO. [...]
Externí odkaz:
https://doaj.org/article/cb37cd29ff6d47e0a0c5bd3777de2396
Autor:
Rocio Paucar-Bernabé, Elsa Moreno-Viguri, Rubén Martín-Escolano, Mery Santivañez-Veliz, Amaya Azqueta, Nuria Cirauqui, Manuel Sánchez-Moreno, Silvia Pérez-Silanes
Publikováno v:
Proceedings, Vol 1, Iss 6, p 659 (2017)
Chagas disease (CD) is a neglected tropical disease caused by the parasite Trypanosoma cruzi [1]. [...]
Externí odkaz:
https://doaj.org/article/849c25589b694c129681dd5690071011
Autor:
Manuel Sánchez-Moreno, Silvia Pérez-Silanes, Clotilde Marín, Rubén Martín-Escolano, Rocio Paucar, Elsa Moreno-Viguri, Nuria Cirauqui
Publikováno v:
ChemistrySelect. 4:8112-8121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd73a7310a88bf82f7de3eab0820a52
https://doi.org/10.1002/slct.201901108
https://doi.org/10.1002/slct.201901108
Publikováno v:
European Journal of Medicinal Chemistry. 155:459-482
The development of safe and affordable antiparasitic agents effective against neglected tropical diseases is a big challenge of the drug discovery. The drugs currently employed have limitations such as poor efficacy, drug resistance or side effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674f0e773a6beabdeef5874d1ee34f3e
https://doi.org/10.1016/j.ejmech.2018.05.044
https://doi.org/10.1016/j.ejmech.2018.05.044
Autor:
Mery Santivañez-Veliz, Elsa Moreno-Viguri, Silvia Pérez-Silanes, Chung Man Chin, Jean Leandro dos Santos, Guilherme Felipe dos Santos Fernandes, Rocio Paucar
Publikováno v:
Journal of Heterocyclic Chemistry. 54:2380-2388
Quinoxaline 1,4-di-N-oxide (QdNO) and N-acylhydrazone subunit are considered privileged scaffolds in medicinal chemistry because of its wide spectrum of biological activities, such as antibacterial, antitubercular, antiviral, anticancer, and antifung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc81885c1759b7d61eb77f5e4c4f3b70
https://doi.org/10.1002/jhet.2830
https://doi.org/10.1002/jhet.2830
Autor:
Clotilde Marín, Rubén Martín-Escolano, Rocio Paucar, Manuel Sánchez-Moreno, Elsa Moreno-Viguri, Amaya Azqueta, Silvia Pérez-Silanes, Nuria Cirauqui
Publikováno v:
Bioorganicmedicinal chemistry. 27(17)
The current chemotherapy against Chagas disease is inadequate and insufficient. A series of ten Mannich base-type derivatives have been synthesized to evaluate their in vitro antichagasic activity. After a preliminary screening, compounds 7 and 9 wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c95e2aae782b939697e9c3b0cb8e815
https://pubmed.ncbi.nlm.nih.gov/31345745
https://pubmed.ncbi.nlm.nih.gov/31345745
Autor:
Marina Jimenez-Lopez, Rubén Martín-Escolano, Salvador Zamora Ledesma, Clotilde Marín, Adela López de Cerain, Carmen Jiménez-Montes, Manuel Sánchez-Moreno, Mery Santivañez-Veliz, Elsa Moreno-Viguri, Amaya Azqueta, Silvia Pérez-Silanes, Álvaro Martín-Montes, Nuria Cirauqui
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
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Chagas disease is a neglected tropical disease with 6-7 million people infected worldwide and there is no effective treatment. Therefore, there is an urgent need to continue researching in order to discover novel therapeutic alternatives. We present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423c105944489331189f414f684b15cf
https://doi.org/10.1021/acs.jmedchem.6b00784
https://doi.org/10.1021/acs.jmedchem.6b00784
Autor:
Hugo Cerecetto, Amaya Azqueta, Enrique Torres, Silvia Pérez-Silanes, Elsa Moreno-Viguri, Javier Varela, Leire Arbillaga, Mercedes González
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:903-906
We report the synthesis and in vitro activity against Trypanosoma cruzi epimastigotes of 15 novel quinoxaline derivatives. Ten of the derivatives presented IC50 values lower than the reference drugs Nfx and Bzn; four of them standed out with IC50 val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac58027d61be224b176eb39b372366a7
https://doi.org/10.1016/j.bmcl.2015.12.070
https://doi.org/10.1016/j.bmcl.2015.12.070
Autor:
Rubén Martín-Escolano, Elsa Moreno-Viguri, Manuel Sánchez-Moreno, Elisabetta Gabano, Carlos Rangel Rodrigues, Mauro Ravera, Silvia Pérez-Silanes, Rocio Paucar, Clotilde Marín, Nuria Cirauqui
Publikováno v:
European journal of medicinal chemistry. 163
Chagas disease is a neglected chronical parasitosis caused by the parasite Trypanosoma cruzi (T. cruzi). Nine ferrocenyl Mannich base derivatives were synthetized and characterized to explore their in vitro activity on three T. cruzi strains of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9642d75c2f782d0e5500c218b84a2b8d
https://pubmed.ncbi.nlm.nih.gov/30554132
https://pubmed.ncbi.nlm.nih.gov/30554132
Autor:
Silvia Pérez-Silanes, Rubén Martín-Escolano, Clotilde Marín, Amaya Azqueta, Elsa Moreno-Viguri, Encarnación Medina-Carmona, Rocio Paucar, Nuria Cirauqui, Angel L. Pey, Mery Santivañez-Veliz, Manuel Sánchez-Moreno, Álvaro Martín-Montes
Publikováno v:
Journal of medicinal chemistry. 61(13)
Chagas disease is a potentially life-threatening and neglected tropical disease caused by Trypanosoma cruzi. One of the most important challenges related to Chagas disease is the search for new, safe, effective, and affordable drugs since the current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556b6a5a27c069e0f7cf60779c50ebfc
https://pubmed.ncbi.nlm.nih.gov/29883536
https://pubmed.ncbi.nlm.nih.gov/29883536