Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Elsa Irving"'
Autor:
Elsa Irving, Andrew W. Stoker
Publikováno v:
Molecules, Vol 22, Iss 12, p 2269 (2017)
Phosphotyrosine signaling is regulated by the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Here we discuss the potential of vanadium derivatives as PTP enzyme inhibitors and metallotherapeutics. We des
Externí odkaz:
https://doaj.org/article/0a5b8ba2623b4fdc8284ba755ef8e8e8
Publikováno v:
Cancers, Vol 14, Iss 44, p 44 (2022)
Cancers
Cancers
Simple Summary PARP inhibitors (PARPi) are current treatment options for patients with ovarian, breast, pancreatic or prostate cancer. Although PARPi have transformed the patient journey in these disease settings, resistance eventually develops, leav
Publikováno v:
Trends in Cell Biology. 31:628-643
Ubiquitin and ubiquitin-like proteins (UBLs) function as critical post-translational modifiers in the maintenance of genome stability. Ubiquitin/UBL-conjugating enzymes (E2s) are responsible, as part of a wider enzymatic cascade, for transferring sin
Publikováno v:
Annals of Oncology. 32:103-112
Background Germline mutations in the BRCA1 or BRCA2 (BRCA) genes predispose to hereditary breast and ovarian cancer and, mostly in the case of BRCA2, are also prevalent in cases of pancreatic and prostate malignancies. Tumours from these patients ten
Autor:
Elsa Irving, Simon Eaton, Ari Lehtonen, Stephen L. Hart, Ruhina Maeshima, Andrew W. Stoker, Aristides D. Tagalakis
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Oxidovanadium complexes with organic ligands are well known to have cytotoxic or differentiating capabilities against a range of cancer cell types. Their limited use in clinical testing though has resulted largely from uncertainties about the long-te
Germline mutations in the BRCA1 or BRCA2 genes predispose to hereditary breast and ovarian cancer and, mostly in the case of BRCA2, are also prevalent in cases of pancreatic and prostate malignancies. Tumours from these patients tend to lose both cop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc23d72629e637085a7b1d302fd97231
https://doi.org/10.1101/2020.07.22.215673
https://doi.org/10.1101/2020.07.22.215673
Publikováno v:
Trends in molecular medicine. 26(12)
Autor:
Michael Orford, Stephen L. Hart, Elsa Irving, Claire Simons, Alessia Di Florio, Mayuran Mathiyalakan, Shreya Shah, Aristides D. Tagalakis, Maja Bilip, Andrew W. Stoker, Ruhina Maeshima, Simon Eaton
Publikováno v:
Journal of Drug Targeting
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells. However, although therapeutically effective, retinoids have only modest benefits and suffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15558e37caa7d3d2630e0e1e269df268