Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response

Autor: Jean-Jacques Hoarau, Marie-Christine Jaffar Bandjee, Pascale Krejbich Trotot, Trina Das, Ghislaine Li-Pat-Yuen, Bérengère Dassa, Mélanie Denizot, Elsa Guichard, Anne Ribera, Tawfiq Henni, Frank Tallet, Marie Pierre Moiton, Bernard Alex Gauzère, Sandrine Bruniquet, Zaïnoul Jaffar Bandjee, Philippe Morbidelli, Gérard Martigny, Michel Jolivet, Frederick Gay, Marc Grandadam, Hugues Tolou, Vincent Vieillard, Patrice Debré, Brigitte Autran, Philippe Gasque

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 184 (10), pp.5914--5927. ⟨10.4049/jimmunol.0900255⟩
Journal of Immunology, 2010, 184 (10), pp.5914--5927. ⟨10.4049/jimmunol.0900255⟩

Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV wa

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https://hal.univ-reunion.fr/hal-01285461