Zobrazeno 1 - 10 of 58 pro vyhledávání: '"Elsa D Garcin"'
1
Akademický článek
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
Autor: Thomas W Miller, Joshua D Amason, Elsa D Garcin, Laurence Lamy, Patricia K Dranchak, Ryan Macarthur, John Braisted, Jeffrey S Rubin, Teresa L Burgess, Catherine L Farrell, David D Roberts, James Inglese
Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0218897 (2019)
CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types. This has led to the
Externí odkaz: https://doaj.org/article/72f1809b5d2d4362be19df63504e4ef9
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2
Akademický článek
Regulation of Soluble Guanylate Cyclase by Matricellular Thrombospondins: Implications for Blood Flow
Autor: Natasha M Rogers, Franziska eSeeger, Elsa D Garcin, David D Roberts, Jeffrey S Isenberg
Publikováno v: Frontiers in Physiology, Vol 5 (2014)
Nitric oxide (NO) maintains cardiovascular health by activating soluble guanylate cyclase (sGC) to increase cellular cGMP levels. Cardiovascular disease is characterized by decreased NO-sGC-cGMP signaling. Pharmacological activators and stimulators o
Externí odkaz: https://doaj.org/article/efb1482d2cf7468ba70021fc85367b1a
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3
Giant viruses of the Megavirinae subfamily possess biosynthetic pathways to produce rare bacterial-like sugars in a clade-specific manner
Autor: Anna Notaro, Olivier Poirot, Elsa D Garcin, Sebastien Nin, Antonio Molinaro, Michela Tonetti, Cristina De Castro, Chantal Abergel
Publikováno v: microLife
microLife, 2022, 3, ⟨10.1093/femsml/uqac002⟩
Oxford University Press
The recent discovery that giant viruses encode proteins related to sugar synthesis and processing paved the way for the study of their glycosylation machinery. We focused on the proposed Megavirinae subfamily, for which glycan-related genes were prop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec0284dd83ed18002fa55d80ccb303c
https://hal-amu.archives-ouvertes.fr/hal-03656819
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4
A fusion of the Bacteroides fragilis ferrous iron import proteins reveals a role for FeoA in stabilizing GTP-bound FeoB
Autor: Alex E. Sestok, Janae B. Brown, Juliet O. Obi, Sean M. O’Sullivan, Elsa D. Garcin, Daniel J. Deredge, Aaron T. Smith
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2022, 298 (4), pp.101808. ⟨10.1016/j.jbc.2022.101808⟩
International audience; Iron is an essential element for nearly all organisms, and under anoxic and/or reducing conditions, Fe2+ is the dominant form of iron available to bacteria. The ferrous iron transport (Feo) system is the primary prokaryotic Fe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27c210d3dac2aff2f9e074b8b8c94be
https://pubmed.ncbi.nlm.nih.gov/35271852
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5
Biochemical and structural characterization of the fused Bacteroides fragilis NFeoAB domain reveals a role for FeoA
Autor: Janae B. Brown, Aaron T. Smith, Daniel Deredge, Juliet O. Obi, Sean M. O’Sullivan, Elsa D. Garcin, Alex E. Sestok
Iron is an essential element for nearly all organisms, and under anoxic and/or reducing conditions, Fe2+ is the dominant form of iron available to bacteria. The ferrous iron transport (Feo) system has been identified as the primary prokaryotic Fe2+ i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46174f6dda505608351d2cf8b13bf830
https://doi.org/10.1101/2021.09.29.462438
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6
Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism
Autor: Sam Giannakoulias, Xin-Qiu Yao, Elsa D. Garcin, Kenneth Childers, Joshua Amason, Donald Hamelberg
Publikováno v: The Journal of Biological Chemistry
Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) and a central component of the NO-cGMP pathway, critical to cardiovascular function. NO binding to the N-terminal sensor domain in sGC enhances the cyclase activity of the C-te
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f180a27be5f2c9c297d1094c75b4702d
https://doi.org/10.1074/jbc.ra119.011010
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7
GAPDH as a model non-canonical AU-rich RNA binding protein
Autor: Elsa D. Garcin
Publikováno v: Seminars in Cell & Developmental Biology. 86:162-173
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays a key role in glycolysis but is also known for its involvement in a myriad of extra-glycolytic functions. While GAPDH is not the only enzyme with established moonlighting roles, it shows great di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdc710f3317fb0b643db01366eba0e0
https://doi.org/10.1016/j.semcdb.2018.03.013
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8
Nitric Oxide: Synthesis and Action
Autor: Kenneth Childers, Elsa D. Garcin
Publikováno v: eLS
Nitric oxide (NO) is a diatomic radical implicated in a variety of pathways including vascular homeostasis, neurotransmission and immune defence. NO is produced endogenously by three nitric oxide synthases (NOS) and can also be formed from nitrates a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a766998896686efc2fc11ccd38e4090a
https://doi.org/10.1002/9780470015902.a0000634.pub2
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9
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors
Autor: Elsa D. Garcin, Laurence Lamy, Joshua D. Amason, James Inglese, Ryan MacArthur, Jeffrey S. Rubin, Teresa L. Burgess, Catherine L. Farrell, Thomas W. Miller, Patricia Dranchak, John C. Braisted, David D. Roberts
Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0218897 (2019)
CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types. This has led to the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9f71df68c89b0c1dc0cddf807f4f74
http://europepmc.org/articles/PMC6611588
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10
A new paradigm for gaseous ligand selectivity of hemoproteins highlighted by soluble guanylate cyclase
Autor: Ah-Lim Tsai, Gang Wu, Emil Martin, Vladimir Berka, Wen Liu, Elsa D. Garcin
Publikováno v: J Inorg Biochem
Journal of Inorganic Biochemistry
Journal of Inorganic Biochemistry, 2022, 214, ⟨10.1016/j.jinorgbio.2020.111267⟩
Journal of Inorganic Biochemistry, Elsevier, 2021, 214, pp.111267. ⟨10.1016/j.jinorgbio.2020.111267⟩
Journal of Inorganic Biochemistry, 2021, 214, pp.111267. ⟨10.1016/j.jinorgbio.2020.111267⟩
Nitric oxide (NO), carbon monoxide (CO), and oxygen (O(2)) are important physiological messengers whose concentrations vary in a remarkable range, [NO] typically from nM to several μM while [O(2)] reaching to hundreds of μM. One of the machineries
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d369f213d3f6d8e866bf740a8431aa
https://doi.org/10.1016/j.jinorgbio.2020.111267
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