The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

Autor: Noémie Cresto, Marie-Claude Gaillard, Camille Gardier, Francesco Gubinelli, Elsa Diguet, Déborah Bellet, Laurine Legroux, Julien Mitja, Gwenaëlle Auregan, Martine Guillermier, Charlène Josephine, Caroline Jan, Noëlle Dufour, Alain Joliot, Philippe Hantraye, Gilles Bonvento, Nicole Déglon, Alexis-Pierre Bemelmans, Karine Cambon, Géraldine Liot, Emmanuel Brouillet

Publikováno v: Neurobiology of Disease, Vol 134, Iss , Pp - (2020)

The G2019S substitution in the kinase domain of LRRK2 (LRRK2G2019S) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects of LRRK2G2019S are thought to result from an increase in its kinase activity as compared t

Externí odkaz: https://doaj.org/article/f99d8776c12c4a7bb6880f866319890e

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

Autor: Martine Guillermier, Marie-Claude Gaillard, Géraldine Liot, Déborah Bellet, Gwenaëlle Auregan, Elsa Diguet, Nicole Déglon, Noelle Dufour, Philippe Hantraye, Francesco Gubinelli, Julien Mitja, Karine Cambon, Noémie Cresto, Emmanuel Brouillet, Charlène Joséphine, Alain Joliot, Camille Gardier, Caroline Jan, Gilles Bonvento, Laurine Legroux, Alexis-Pierre Bemelmans

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2020, 134, pp.104614. ⟨10.1016/j.nbd.2019.104614⟩
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
Neurobiology of Disease, 2020, 134, pp.104614. ⟨10.1016/j.nbd.2019.104614⟩

International audience; The G2019S substitution in the kinase domain of LRRK2 (LRRK2 G2019S) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects of LRRK2 G2019S are thought to result from an increase in its kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24321246af441b617fd04891e482496
https://hal.archives-ouvertes.fr/hal-03043360/document

Advanced imaging of transplant survival, fate, differentiation, and integration

Autor: Nadja, Van Camp, Elsa, Diguet, Philippe, Hantraye

Publikováno v: Progress in brain research. 230

Stem cell-based therapy trials for the treatment of neurodegenerative diseases such as Parkinson's and Huntington's disease are being actively prepared both at the preclinical and clinical level. Preclinical validation of these stem cell transplantat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d2e83fdac68fcdf38641bf0ea91a21b
https://pubmed.ncbi.nlm.nih.gov/28552233

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease

Autor: Philippe Hantraye, Bengt Mattsson, Shane Grealish, Elsa Diguet, Andreas Heuer, Malin Parmar, Agnete Kirkeby, Yann Bramoullé, Anselme L. Perrier, Nadja Van Camp, Anders Björklund

Publikováno v: Cell Stem Cell
Cell Stem Cell; 15(5), pp 653-665 (2014)

Summary Considerable progress has been made in generating fully functional and transplantable dopamine neurons from human embryonic stem cells (hESCs). Before these cells can be used for cell replacement therapy in Parkinson’s disease (PD), it is i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be3a68d4359c2ef98e50ab727601664
http://europepmc.org/articles/PMC4232736

Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy)

Autor: Gregor K. Wenning, François Tison, Zoe Puschban, Christoph Scherfler, Werner Poewe, Elsa Diguet, Nadia Stefanova, T. Sather

Publikováno v: Journal of Neural Transmission. 112:1025-1033

We investigated neuroprotective effects of riluzole, an anti-glutamatergic agent that is FDA approved for disease-modifying therapy in amyotrophic lateral sclerosis (ALS), in an established double lesion rat model of striatonigral degeneration (SND),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd078753313e448382cda8a1d16e3a4
https://doi.org/10.1007/s00702-004-0245-5