Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Els Waegemans"'
Autor:
Inge Van de Walle, Anne-Catherine Dolens, Kaat Durinck, Katrien De Mulder, Wouter Van Loocke, Sagar Damle, Els Waegemans, Jelle De Medts, Imke Velghe, Magda De Smedt, Bart Vandekerckhove, Tessa Kerre, Jean Plum, Georges Leclercq, Ellen V. Rothenberg, Pieter Van Vlierberghe, Frank Speleman, Tom Taghon
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Strong Notch signalling promotes initial T cell lineage specification of lymphoid progenitors but is also permissive for thymic natural killer (NK) cell development. Here the authors show that GATA3 directs human T-lineage commitment by modulating No
Externí odkaz:
https://doaj.org/article/69f154ad67fa47219da5b76adf207d5e
Autor:
Kaat Durinck, Bart Vandekerckhove, Jelle De Medts, Ellen V. Rothenberg, Els Waegemans, Anne-Catherine Dolens, Frank Speleman, Tom Taghon, Pieter Van Vlierberghe, Georges Leclercq, Inge Van de Walle, Wouter Van Loocke, Magda De Smedt, Tessa Kerre, Sagar S. Damle, Imke Velghe, Katrien De Mulder, Jean Plum
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
NATURE COMMUNICATIONS
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
NATURE COMMUNICATIONS
The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at least two sequential developmental stages. Following Notch1-dependent T-cell lineage specification during which the first T-cell lineage genes are expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e33d29bec94b33dcf4cde80dad85cdd
https://doi.org/10.1038/ncomms11171
https://doi.org/10.1038/ncomms11171
Autor:
Filip De Vos, Caroline Dumolyn, Liesbet Vervoort, Andrew M. Scott, Sarah K. Baird, Steven Staelens, Els Waegemans, Ingrid Burvenich, Magali Van Steenkiste
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 25:193-205
The use of radiolabeled antibodies that are able to target primary tumors as well as metastatic tumor sites with minimal reactivity to normal tissues is a promising approach for treating pancreatic cancer. In this study, the integrin alpha(v)beta(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8299aa300594ee9ad93cd2f33ecc5d48
https://doi.org/10.1089/cbr.2009.0696
https://doi.org/10.1089/cbr.2009.0696
Autor:
Jelle De Medts, Inge Van de Walle, Tessa Kerre, Els Waegemans, Magda De Smedt, Tom Taghon, Tao Wang, Jean Plum, Bart Vandekerckhove, Georges Leclercq
Publikováno v:
JOURNAL OF IMMUNOLOGY
Although the role for the individual Notch receptors in early hematopoiesis have been thoroughly investigated in mouse, studies in human have been mostly limited to the use of pan-Notch inhibitors. However, such studies in human are important to pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c25eb38ab4ee06c06f1093fe560341
https://biblio.ugent.be/publication/5801548
https://biblio.ugent.be/publication/5801548
Autor:
Magda De Smedt, Ute Koch, Sylvia Snauwaert, Greet De Smet, Inge Van de Walle, Thomas Gridley, Tessa Kerre, Jean Plum, Jelle De Medts, Freddy Radtke, Tao Wang, Tom Taghon, Els Waegemans, Bart Vandekerckhove, Georges Leclercq
Publikováno v:
The Journal of Experimental Medicine
J.Ex.Med.
J.Ex.Med.
Jagged2 preferentially signals through Notch3 to promote γδ T cell development.
In humans, high Notch activation promotes γδ T cell development, whereas lower levels promote αβ-lineage differentiation. How these different Notch signals are
In humans, high Notch activation promotes γδ T cell development, whereas lower levels promote αβ-lineage differentiation. How these different Notch signals are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41eed4820aaa911d46a4ee0c594107da
https://pubmed.ncbi.nlm.nih.gov/23530123
https://pubmed.ncbi.nlm.nih.gov/23530123
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783642242939
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species. Here, we review our cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adc0c5b918cd337f711f7d9c1c2cc6b9
https://doi.org/10.1007/82_2012_230
https://doi.org/10.1007/82_2012_230
Autor:
Jean Plum, Irwin D. Bernstein, Tom Taghon, Inge Van de Walle, Bart Vandekerckhove, Cynthia J. Guidos, Els Waegemans, Greet De Smet, Magda De Smedt, Jon C. Aster, Bruno Kyewski, Martina Gärtner, Georges Leclercq
Publikováno v:
Blood; Vol 117
Notch signaling critically mediates various hematopoietic lineage decisions and is induced in mammals by Notch ligands that are classified into 2 families, Delta-like (Delta-like-1, -3 and -4) and Jagged (Jagged1 and Jagged2), based on structural hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83aeb1994ba888dd3fa35f3f6e9e0e79
https://pubmed.ncbi.nlm.nih.gov/21372153
https://pubmed.ncbi.nlm.nih.gov/21372153
Autor:
Tom Taghon, Inge Van de Walle, Els Waegemans, Jelle De Medts, Greet De Smet, Magda De Smedt, Bart Vandekerckhove, Tessa Kerre, Georges Leclercq, Tao Wang, Jean Plum
Publikováno v:
The Journal of Immunology. 188:111.29-111.29
Differential Notch signal strength influences the αβ versus γδ T-cell lineage decision in both mouse and human. Here, we show that the Notch ligands Delta-like-4, Jagged1 and Jagged2, differentially impact this lineage decision in human. Whereas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f797132f8c7fdc79f54e07f00568e78
https://doi.org/10.4049/jimmunol.188.supp.111.29
https://doi.org/10.4049/jimmunol.188.supp.111.29