Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved]

Autor: Carmen Mirabelli, Els Scheers, Johan Neyts

Publikováno v: F1000Research, Vol 6 (2017)

Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhi

Externí odkaz: https://doaj.org/article/c160f0842a324e87af678042e5fc82dd

Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication

Autor: Roberto Cirilli, Carmen Mirabelli, Romano Silvestri, Els Scheers, Giuseppe La Regina, Patrice Vanelle, Laurène Da Costa, Adriano Casulli, Thierry Terme, Antonio Coluccia, Carole Di Giorgio, Johan Neyts, Manon Roche

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (18), pp.8402-8416. ⟨10.1021/acs.jmedchem.8b00931⟩
Journal of Medicinal Chemistry, 2018, 61 (18), pp.8402-8416. ⟨10.1021/acs.jmedchem.8b00931⟩

International audience; Rhinoviruses (RVs) have been linked to exacerbations of many pulmonary diseases, thus increasing morbidity and/or mortality in subjects at risk. Unfortunately, the wide variety of RV genotypes constitutes a major hindrance for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34d6dd160e3ee25815b9772c1619a2b
https://hal-amu.archives-ouvertes.fr/hal-02094656

Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study

Autor: Romano Silvestri, Alessia Rosetti, Roberto Cirilli, Manon Roche, Carmen Mirabelli, Thierry Terme, Antonio Coluccia, Johan Neyts, Els Scheers, Patrice Vanelle, Laurène Da Costa

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2017, 140, pp.528--541. ⟨10.1016/j.ejmech.2017.09.036⟩
European Journal of Medicinal Chemistry, 2017, 140, pp.528--541. ⟨10.1016/j.ejmech.2017.09.036⟩

International audience; Rhinovirus (RV), member of the Enterovirus genus, is known to be involved in more than half of the common colds. Through advances in molecular biology, rhinoviruses have also been associated with exacerbations of chronic pulmo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9604c1fbe37bad3cb164799c72e9a95a
https://hal-amu.archives-ouvertes.fr/hal-01774249

A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication

Autor: Chong-Kyo Lee, Jin Woo Kim, Jin Soo Shin, Jae-Du Ha, Joo-Youn Lee, Els Scheers, Young-Sik Jung, Chonsaeng Kim, Johan Neyts, Yu Kyoung Jung, Soo Bong Han

Publikováno v: Journal of medicinal chemistry. 60(13)

Human rhinoviruses (hRVs) are the main causative pathogen for common colds and are associated with the exacerbation of asthma. The wide variety in hRV serotypes has complicated the development of rhinovirus replication inhibitors. In the current inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd342f7efa53d2b29389ec4071ee7f2
https://pubmed.ncbi.nlm.nih.gov/28581749

A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication.

Autor: Jinwoo Kim, Yu Kyoung Jung, Chonsaeng Kim, Jin Soo Shin, Els Scheers, Joo-Youn Lee, Soo Bong Han, Chong-Kyo Lee, Johan Neyts, Jae-Du Ha, Young-Sik Jun

Publikováno v: Journal of Medicinal Chemistry; Jul2017, Vol. 60 Issue 13, p5472-5492, 21p