Výsledky vyhledávání - "Els Robanus Maandag"

Akademický článek

Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids.

Autor: Els Robanus-Maandag, Cathy Bosch, Saeid Amini-Nik, Jeroen Knijnenburg, Karoly Szuhai, Pascale Cervera, Raymond Poon, Diana Eccles, Paolo Radice, Marco Giovannini, Benjamin A Alman, Sabine Tejpar, Peter Devilee, Riccardo Fodde

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24354 (2011)

Desmoid tumours (also called deep or aggressive fibromatoses) are potentially life-threatening fibromatous lesions. Hereditary desmoid tumours arise in individuals affected by either familial adenomatous polyposis (FAP) or hereditary desmoid disease

Externí odkaz: https://doaj.org/article/22bb7a60e6ca4626a3dce59df9d1e5f2

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Overexpression of P70 S6 kinase protein is associated with increased risk of locoregional recurrence in node-negative premenopausal early breast cancer patients

Autor: M.J. van de Vijver, Catherine Legrand, C.J.H. van de Velde, C J A Bosch, P C Clahsen, L. J. C. M. Van Den Broek, J. A. van der Hage, Els Robanus-Maandag

Publikováno v: British Journal of Cancer
British journal of cancer, 90(8), 1543-1550. Nature Publishing Group

The RPS6KB1 gene is amplified and overexpressed in approximately 10% of breast carcinomas and has been found associated with poor prognosis. We studied the prognostic significance of P70 S6 kinase protein (PS6K) overexpression in a series of 452 node

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcc0e0c53d81a22ff2b4eae13fef983
http://europepmc.org/articles/PMC2409704

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p107 is a suppressor of retinoblastoma development in pRb-deficient mice

Autor: Maria-Luisa Carrozza, Martin van der Valk, Anton Berns, Marleen Dekker, Hein te Riele, Els Robanus-Maandag, Jean-Claude Jeanny, Jan-Hermen Dannenberg

Publikováno v: Genes & Development. 12:1599-1609

Hemizygosity for the retinoblastoma gene RB in man strongly predisposes to retinoblastoma. In the mouse, however,Rb hemizygosity leaves the retina normal, whereas inRb−/− chimeras pRb-deficient retinoblasts undergo apoptosis. To test whether conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45c2834b2a73785737a59be4bce96b1
https://doi.org/10.1101/gad.12.11.1599

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Association of C-MYC amplification with progression from the in situ to the invasive stage in C-MYC-amplified breast carcinomas

Autor: Augustinus A. M. Hart, I. F. Faneyte, Johannes L. Peterse, Petra Kristel, Petra M. Nederlof, Cathy A.J. Bosch, Marc J. van de Vijver, Els Robanus-Maandag

Publikováno v: Journal of pathology, 201(1), 75-82. John Wiley and Sons Ltd

Human carcinoma in situ of the breast already demonstrates genomic changes found in invasive lesions. However, no specific genetic alterations have previously been identified that are associated with progression from the in situ to the invasive stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c89f149f842849a5743dadb36b99ba9
https://pure.amc.nl/en/publications/association-of-cmyc-amplification-with-progression-from-the-in-situ-to-the-invasive-stage-in-cmycamplified-breast-carcinomas(acc9a638-f66b-4fbf-bc6d-a6162833807d).html

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Histological type and marker expression of the primary tumour compared with its local recurrence after breast-conserving therapy for ductal carcinoma in situ

Autor: S Pilotti, Luc Duchateau, Nina Bijker, C. Duval, Els Robanus-Maandag, Cathy A.J. Bosch, M.J. van de Vijver, Johannes L. Peterse

Publikováno v: British Journal of Cancer
British journal of cancer, 84(4), 539-544. Nature Publishing Group

We have investigated primary ductal carcinomas in situ (DCIS) of the breast and their local recurrences after breast-conserving therapy (BCT) for histological characteristics and marker expression. Patients who were randomized in the EORTC trial 1085

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce3c04773c3db4f30c90f18a718f565
https://pubmed.ncbi.nlm.nih.gov/11207051

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Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers

Autor: M.J. van de Vijver, Petra M. Nederlof, M van Lohuizen, T van Welsem, Jacqueline J.L. Jacobs, Petra Kristel, Merel Lingbeek, P Keblusek, E Y Koh, George Q. Daley, Els Robanus-Maandag

Publikováno v: Nature genetics, 26(3), 291-299. Nature Publishing Group

To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts deficient for the oncogene Bmi1. We identified the T-box member TBX2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1e40a0377039130d1a1ea9d0bf806c
https://pubmed.ncbi.nlm.nih.gov/11062467

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Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2

Autor: Gilles Thomas, Martin van der Valk, Laurence Goutebroze, Vincent Abramowski, Anton Berns, Marco Giovannini, Michiko Niwa-Kawakita, Els Robanus-Maandag, James M. Woodruff

Publikováno v: Genes and Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2000, 14 (13), pp.1617-30
Europe PubMed Central
Scopus-Elsevier

Hemizygosity for the NF2 gene in humans causes a syndromic susceptibility to schwannoma development. However, Nf2hemizygous mice do not develop schwannomas but mainly osteosarcomas. In the tumors of both species, the second Nf2 allele is inactivated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af42f3696383c0750ff654837c07158
https://europepmc.org/articles/PMC316733/

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In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3

Autor: Anton Berns, Jos Jonkers, Els Robanus-Maandag, Martin van der Valk, Olivier Destrée, Renée van Amerongen, Miranda Molenaar

Publikováno v: Mechanisms of development. 88(2)

The Frat1 gene was first identified as a proto-oncogene involved in progression of mouse T cell lymphomas. More recently, FRAT/GBP (GSK-3beta Binding Protein) family members have been recognized as critical components of the Wnt signal transduction p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87946d84697346a3594f19ae8501f963
https://pubmed.ncbi.nlm.nih.gov/10534617

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