P1333: CHEMOTHERAPY-ACTIVATED HSCS ARE DEFINED BY HIGHLY INCREASED MITOCHONDRIAL MASS AND POTENTIAL INDEPENDENT OF CELL CYCLE STATUS

Autor: Julia Sjöberg, Anna Rydström, Jonas Larsson, Tariq Enver, Els Mansell, Valgardur Sigurdsson

Publikováno v: HemaSphere, Vol 7, p e4596119 (2023)

Externí odkaz: https://doaj.org/article/9a700c674c2f4385996f7bbe6a54286d

Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells

Autor: Sarah Warsi, Maria Dahl, Emma M. K. Smith, Anna Rydstrom, Els Mansell, Valgardur Sigurdsson, Julia Sjoberg, Shamit Soneji, Emma Rorby, Kavitha Siva, Tan H. M. Grahn, Yang Liu, Ulrika Blank, Goran Karlsson, Stefan Karlsson

Publikováno v: Haematologica, Vol 107, Iss 12 (2022)

Even though hematopoietic stem cells (HSC) are characterized by their ability to self-renew and differentiate, they primarily reside in quiescence. Despite the immense importance of this quiescent state, its maintenance and regulation is still incomp

Externí odkaz: https://doaj.org/article/89aef74030df4d8c80376944eafe6730

New hallmarks of ageing:a 2022 Copenhagen ageing meeting summary

Autor: Tomas Schmauck-Medina, Adrian Molière, Sofie Lautrup, Jianying Zhang, Stefan Chlopicki, Helena Borland Madsen, Shuqin Cao, Casper Soendenbroe, Els Mansell, Mark Bitsch Vestergaard, Zhiquan Li, Yosef Shiloh, Patricia L. Opresko, Jean-Marc Egly, Thomas Kirkwood, Eric Verdin, Vilhelm A. Bohr, Lynne S. Cox, Tinna Stevnsner, Lene Juel Rasmussen, Evandro F. Fang

Publikováno v: Schmauck-Medina, T, Molière, A, Lautrup, S, Zhang, J, Chlopicki, S, Madsen, H B, Cao, S, Soendenbroe, C, Mansell, E, Vestergaard, M B, Li, Z, Shiloh, Y, Opresko, P L, Egly, J M, Kirkwood, T, Verdin, E, Bohr, V A, Cox, L S, Stevnsner, T, Rasmussen, L J & Fang, E F 2022, ' New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary ', Aging, vol. 14, no. 16, pp. 6829-6839 . https://doi.org/10.18632/aging.204248

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0561f3f991fdf490afcba5864a09972c
https://curis.ku.dk/ws/files/319877704/aging_v14i16_204248.pdf

3176 – MAC-1 MARKS A QUIESCENT AND FUNCTIONALLY SUPERIOR HSC SUBSET DURING REGENERATION

Autor: Anna Rydstrom, Els Mansell, Valgardur Sigurdsson, Kenichi Miharada, Shamit Soneji, Jonas Larsson

Publikováno v: Experimental Hematology. 111:S132-S133

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26f0c708b718ea781db5960420f52df9
https://doi.org/10.1016/j.exphem.2022.07.232

DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation

Autor: C. Patrick Case, Camille Malouf, Nahid Zareian, Katrin Ottersbach, Allison Blair, Natalie Brown, Christopher Badie, Chrysa Kapeni, Duncan M. Baird, Jon D. Lane, Els Mansell

Publikováno v: Mansell, E, Zareian, N, Malouf, C, Kapeni, C, Brown, N, Badie, C, Baird, D, Lane, J D, Ottersbach, K, Blair, A & Case, C P 2019, ' DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation ', Scientific Reports, vol. 9, 4370 . https://doi.org/10.1038/s41598-019-39552-0
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Mansell, E, Zareian, N, Malouf, C, Kapeni, C, Brown, N, Badie, C, Baird, D, Lane, J D, Ottersbach, K, Blair, A & Case, C P 2019, ' DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation ', Scientific Reports, vol. 9, no. 1, 4370 . https://doi.org/10.1038/s41598-019-39552-0

For many diseases with a foetal origin, the cause for the disease initiation remains unknown. Common childhood acute leukaemia is thought to be caused by two hits, the first in utero and the second in childhood in response to infection. The mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bb15d1cb9ed8fbad890b049ab4373a
https://www.pure.ed.ac.uk/ws/files/81560618/s41598_019_39552_0.pdf