Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Els M. J. J. Berns"'
Autor:
Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna S. Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M. J. J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Acquired resistance limits the efficacy of PARP inhibitors (PARPi) in high grade serous ovarian cancer (HGSOC). Here, the authors show that inhibition of RNA polymerase I transcription using CX-5461 increases the therapeutic efficacy of PARPi and ove
Externí odkaz:
https://doaj.org/article/e147f3013f3440d1be5ac0b31368773d
Autor:
Silvia R. Vitale, Floris H. Groenendijk, Ronald van Marion, Corine M. Beaufort, Jean C. Helmijr, Hendrikus Jan Dubbink, Winand N. M. Dinjens, Patricia C. Ewing-Graham, Ramon Smolders, Helena C. van Doorn, Ingrid A. Boere, Els M. J. J. Berns, Jozien Helleman, Maurice P. H. M. Jansen
Publikováno v:
Biomolecules, Vol 10, Iss 3, p 415 (2020)
The aim of this study was to determine an optimal workflow to detect TP53 mutations in baseline and longitudinal serum cell free DNA (cfDNA) from high-grade serous ovarian carcinomas (HGSOC) patients and to define whether TP53 mutations are suitable
Externí odkaz:
https://doaj.org/article/76c9e3e5ee1348d4b952b7c5f009f099
Autor:
Arno Kuijper, Antoine M. Snijders, Els M. J. J. Berns, Vibeke Kuenen-Boumeester, Elsken van der Wall, Donna G. Albertson, Paul J. van Diest
Publikováno v:
Cellular Oncology, Vol 31, Iss 1, Pp 31-39 (2009)
Breast phyllodes tumour (PT) is a rare fibroepithelial tumour. The genetic alterations contributing to its tumorigenesis are largely unknown. To identify genomic regions involved in pathogenesis and progression of PTs we obtained genome-wide copy num
Externí odkaz:
https://doaj.org/article/5be97f3f3404424da4c7768023bdbc7d
Autor:
Thomas E Bartlett, Allison Jones, Ellen L Goode, Brooke L Fridley, Julie M Cunningham, Els M J J Berns, Elisabeth Wik, Helga B Salvesen, Ben Davidson, Claes G Trope, Sandrina Lambrechts, Ignace Vergote, Martin Widschwendter
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143178 (2015)
We introduce a novel per-gene measure of intra-gene DNA methylation variability (IGV) based on the Illumina Infinium HumanMethylation450 platform, which is prognostic independently of well-known predictors of clinical outcome. Using IGV, we derive a
Externí odkaz:
https://doaj.org/article/f68cfa1687384e25b95129cb34567de4
Autor:
Jozien, Helleman, Maurice P H M, Jansen, Paul N, Span, Iris L, van Staveren, Leon F A G, Massuger, Marion E, Meijer-van Gelder, Fred C G J, Sweep, Patricia C, Ewing, Maria E L, van der Burg, Gerrit, Stoter, Kees, Nooter, Els M J J, Berns
Publikováno v:
International journal of cancer. 118(8)
The aim of this study is to discover a gene set that can predict resistance to platinum-based chemotherapy in ovarian cancer. The study was performed on 96 primary ovarian adenocarcinoma specimens from 2 hospitals all treated with platinum-based chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bd079eeff7f1e5f5593c0006b82e145
https://pubmed.ncbi.nlm.nih.gov/16619247
https://pubmed.ncbi.nlm.nih.gov/16619247
Autor:
Els M J J, Berns, Jan G M, Klijn, Maxime P, Look, Nicolai, Grebenchtchikov, Rolf, Vossen, Harry, Peters, Anneke, Geurts-Moespot, Henk, Portengen, Iris L, van Staveren, Marion E, Meijer-van Gelder, Bert, Bakker, Fred C G J, Sweep, John A, Foekens
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(4)
In recent studies, we showed that TP53 gene mutation or high levels of cytosolic vascular endothelial growth factor (VEGF) in estrogen receptor (ER)-alpha-positive primary breast tumors predict a poor disease outcome for patients treated with first-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64e2bd015f2e45ca728ef67cf791b777
https://pubmed.ncbi.nlm.nih.gov/12684392
https://pubmed.ncbi.nlm.nih.gov/12684392
Publikováno v:
Nature. 286:713-714
Resistance of mice to the facultative intracellular parasite Listeria monocytogenes involves cellular immunity1, as it can be transferred passively with viable lymphoid cells2 but not with serum. Induction of protective immunity can only be achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cb94a08e83c1587a4065a5739a7198
https://doi.org/10.1038/286713a0
https://doi.org/10.1038/286713a0
Autor:
Corine M Beaufort, Jean C A Helmijr, Anna M Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F J van IJcken, Anouk A J Heine, Marcel Smid, Marco J Koudijs, James D Brenton, Els M J J Berns, Jozien Helleman
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e103988 (2014)
Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed characteriz
Externí odkaz:
https://doaj.org/article/89fef8c147544e4ca580af119453cff1