Immunological memory to hyperphosphorylated tau in asymptomatic individuals

Autor: Jeroen J.M. Hoozemans, Jaap Goudsmit, Hanna Inganäs, Başak Kükrer, Kiana West, Imke Sprengers, Xinyi Li, Michelle Wagner, Heng Zhang, Carrie Arnold, Lucy Chammas, Elissa Keogh, Frederique Bard, Wouter Koudstaal, Veronica Moreno, Julie Kim, Tariq Nahar, Gabriel Pascual, Gerrard Perdok, Laura A. N. Peferoen, Jeroen van Ameijde, Xueyong Zhu, Els C Brinkman van der Linden, Trevin Holland, Jehangir Wadia, Nancy Luckashenak, Zara Fulton, Martha Costa, Martin Koldijk, Berdien Siregar, Lauren Fletcher, R. Anthony Williamson, Adrian Apetri, Wenli Yu, Ian A. Wilson, Otto Diefenbach

Publikováno v: Pascual, G, Wadia, J S, Zhu, X, Keogh, E, Kükrer, B, van Ameijde, J, Inganäs, H, Siregar, B, Perdok, G, Diefenbach, O, Nahar, T, Sprengers, I, Koldijk, M H, der Linden, E C B V, Peferoen, L A, Zhang, H, Yu, W, Li, X, Wagner, M, Moreno, V, Kim, J, Costa, M, West, K, Fulton, Z, Chammas, L, Luckashenak, N, Fletcher, L, Holland, T, Arnold, C, Anthony Williamson, R, Hoozemans, J J, Apetri, A, Bard, F, Wilson, I A, Koudstaal, W & Goudsmit, J 2017, ' Immunological memory to hyperphosphorylated tau in asymptomatic individuals ', Acta Neuropathologica, vol. 133, no. 5, pp. 767-783 . https://doi.org/10.1007/s00401-017-1705-y
Acta Neuropathologica
Acta neuropathologica, 133(5), 767-783. Springer Verlag
Acta Neuropathologica, 133(5), 767-783. Springer Verlag

Several reports have described the presence of antibodies against Alzheimer’s disease-associated hyperphosphorylated forms of tau in serum of healthy individuals. To characterize the specificities that can be found, we interrogated peripheral IgG+

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https://research.vumc.nl/en/publications/c1c61a6a-74cf-4ea9-b3c5-e6a59cbe6284