Mapping the modification of histones by the myeloperoxidase-derived oxidant hypochlorous acid (HOCl)

Autor: Line A.E. Hallberg, Nicoline W. Thorsen, Els A. Hartsema, Per M. Hägglund, Clare L. Hawkins

Publikováno v: Hallberg, L A E, Thorsen, N W, Hartsema, E A, Hägglund, P M & Hawkins, C L 2022, ' Mapping the modification of histones by the myeloperoxidase-derived oxidant hypochlorous acid (HOCl) ', Free Radical Biology and Medicine, vol. 192, pp. 152-164 . https://doi.org/10.1016/j.freeradbiomed.2022.09.016

Histones are critical for the packaging of nuclear DNA and chromatin assembly, which is facilitated by the high abundance of Lys and Arg residues within these proteins. These residues are also the site of a range of post-translational modifications,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad49fb924735d2c4cec874c3ae369cd3
https://doi.org/10.1016/j.freeradbiomed.2022.09.016