Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Els, van der Goot"'
Autor:
Els van der Goot, Stefanie N. Vink, Danique van Vliet, Francjan J. van Spronsen, Joana Falcao Salles, Eddy A. van der Zee
Publikováno v:
Frontiers in Nutrition, Vol 8 (2022)
Phenylketonuria (PKU) is a metabolic disorder caused by a hepatic enzyme deficiency causing high blood and brain levels of the amino acid Phenylalanine (Phe), leading to severe cognitive and psychological deficits that can be prevented, but not compl
Externí odkaz:
https://doaj.org/article/6d1ddfa02a394e99a1cd4289b3ab031f
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/a19d37397b204ef6ab079429701b74a9
Autor:
Vibeke M Bruinenberg, Danique van Vliet, Els van der Goot, Danielle S Counotte, Mirjam Kuhn, Francjan J van Spronsen, Eddy A van der Zee
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213391 (2019)
IntroductionIn phenylketonuria (PKU), a gene mutation in the phenylalanine metabolic pathway causes accumulation of phenylalanine (Phe) in blood and brain. Although early introduction of a Phe-restricted diet can prevent severe symptoms from developi
Externí odkaz:
https://doaj.org/article/19ed840492584282b94b6a33be7e2312
Autor:
Vibeke Marijn Bruinenberg, Els van der Goot, Danique van Vliet, Martijn J. de Groot, Priscila N. Mazzola, Rebecca Heiner-Fokkema, Martijn van Faassen, Francjan J. van Spronsen, Eddy A Van Der Zee
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 10 (2016)
To unravel the role of gene mutations in the healthy and the diseased state, countless studies have tried to link genotype with phenotype. However, over the years, it became clear that the strain of mice can influence these results. Nevertheless, ide
Externí odkaz:
https://doaj.org/article/88b529d24b294bf199d0131f4583b118
Autor:
Els van der Goot, Francjan J. van Spronsen, Femke M. Hormann, Eddy A. van der Zee, Ulrich L. M. Eisel, Vibeke M. Bruinenberg
Publikováno v:
Neurobiology of Learning and Memory. 160:139-143
Toxic levels of phenylalanine in blood and brain is a characteristic of (untreated) phenylketonuria (PKU), leading to cognitive deficits in PKU mice. In addition, our recent findings showed that PKU mice (as well as PKU patients) have a disturbed sle
Autor:
Eddy A. van der Zee, Danique van Vliet, Ido P. Kema, M. Rebecca Heiner-Fokkema, Francjan J. van Spronsen, Vibeke M. Bruinenberg, Martijn van Faassen, Pim de Blaauw, Els van der Goot
Publikováno v:
Journal of Nutritional Biochemistry, 53, 20-27. ELSEVIER SCIENCE INC
Phenylketonuria treatment mainly consists of a phenylalanine-restricted diet but still results in suboptimal neuropsychological outcome, which is at least partly based on cerebral monoamine deficiencies, while, after childhood, treatment compliance d
Autor:
Danique van Vliet, Willem G. van Ginkel, Els van der Goot, Eddy A. van der Zee, Francjan J. van Spronsen, Martijn H. J. R. Faassen, Arndt Vogel, M. Rebecca Heiner-Fokkema
Publikováno v:
Nutrients
Nutrients, Vol 11, Iss 10, p 2486 (2019)
Volume 11
Issue 10
Nutrients, 11(10):2486. MDPI AG
Nutrients, Vol 11, Iss 10, p 2486 (2019)
Volume 11
Issue 10
Nutrients, 11(10):2486. MDPI AG
Tyrosinemia type 1 (TT1) is a rare metabolic disease caused by a defect in the tyrosine degradation pathway. Neurocognitive deficiencies have been described in TT1 patients, that have, among others, been related to changes in plasma large neutral ami
Autor:
Danique, van Vliet, Els, van der Goot, Wiggert G, van Ginkel, Martijn H J R, van Faassen, Pim, de Blaauw, Ido P, Kema, Aurora, Martinez, M Rebecca, Heiner-Fokkema, Eddy A, van der Zee, Francjan J, van Spronsen
Publikováno v:
Nutrients
Many phenylketonuria (PKU) patients cannot adhere to the severe dietary restrictions as advised by the European PKU guidelines, which can be accompanied by aggravated neuropsychological impairments that, at least in part, have been attributed to brai
Autor:
Els, van der Goot, Vibeke M, Bruinenberg, Femke M, Hormann, Ulrich L M, Eisel, Francjan J, van Spronsen, Eddy A, Van der Zee
Publikováno v:
Neurobiology of learning and memory. 160
Toxic levels of phenylalanine in blood and brain is a characteristic of (untreated) phenylketonuria (PKU), leading to cognitive deficits in PKU mice. In addition, our recent findings showed that PKU mice (as well as PKU patients) have a disturbed sle
Autor:
Priscila Nicolao Mazzola, Martijn van Faassen, Martijn de Groot, M. Rebecca Heiner-Fokkema, Eddy A. van der Zee, Vibeke M. Bruinenberg, Els van der Goot, Francjan J. van Spronsen, Danique van Vliet
Publikováno v:
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience, 10(233):233. Frontiers Media S.A.
Frontiers in Behavioral Neuroscience, Vol 10 (2016)
Frontiers in Behavioral Neuroscience, 10(233):233. Frontiers Media S.A.
Frontiers in Behavioral Neuroscience, Vol 10 (2016)
To unravel the role of gene mutations in the healthy and the diseased state, countless studies have tried to link genotype with phenotype. However, over the years, it became clear that the strain of mice can influence these results. Nevertheless, ide