Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Els, Wagenaar"'
Autor:
Wenlong Li, Rolf W. Sparidans, Yaogeng Wang, Margarida L.F. Martins, Dirk R. de Waart, Olaf van Tellingen, Ji-Ying Song, Maria C. Lebre, Stéphanie van Hoppe, Els Wagenaar, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116644- (2024)
Transmembrane drug transporters can be important determinants of the pharmacokinetics, efficacy, and safety profiles of drugs. To investigate the potential cooperative and/or counteracting interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and
Externí odkaz:
https://doaj.org/article/397facf01d244b2c89255b44205a2de9
Autor:
Changpei Gan, Jing Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Els Wagenaar, Yaogeng Wang, Maria C. Lebre, Hilde Rosing, Sjoerd Klarenbeek, Rahmen Bin Ali, Colin Pritchard, Ivo Huijbers, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 2, Pp 618-631 (2023)
The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout
Externí odkaz:
https://doaj.org/article/87e193186c58427c9b561d417264b90f
Autor:
Changpei Gan, Jing Wang, Yaogeng Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Maria C. Lebre, Els Wagenaar, Hilde Rosing, Sjoerd Klarenbeek, Onno B. Bleijerveld, Ji-Ying Song, Maarten Altelaar, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114956- (2023)
Mammalian carboxylesterase 1 enzymes can hydrolyze many xenobiotic chemicals and endogenous lipids. We here identified and characterized a mouse strain (FVB/NKI) in which three of the eight Ces1 genes were spontaneously deleted, removing Ces1c and Ce
Externí odkaz:
https://doaj.org/article/6feb859d901d4d4c97531a2a7f1a6338
Autor:
Wenlong Li, Dilek Iusuf, Rolf W. Sparidans, Els Wagenaar, Yaogeng Wang, Dirk R. de Waart, Margarida L.F. Martins, Stéphanie van Hoppe, Maria C. Lebre, Olaf van Tellingen, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106724- (2023)
Organic anion transporting polypeptide 2B1 (OATP2B1/SLCO2B1) facilitates uptake transport of structurally diverse endogenous and exogenous compounds. To investigate the roles of OATP2B1 in physiology and pharmacology, we established and characterized
Externí odkaz:
https://doaj.org/article/f8d2c24093e5489fb6812b02a2a65cfa
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Fan Lin, Martin van der Valk, Els Wagenaar, Evita van de Steeg, Anita van Esch, Ahmed Elbatsh, Marion Ludwig, Dilek Iusuf
PDF - 278KB, Supplemental figure 1. pH equilibrium between the lactone (closed ring) form and free carboxylic acid (open) form of irinotecan and SN-38. Supplemental Figure 2. Role of Oatp1a/1b uptake transporters in small intestinal (tissue plus cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638cae802c59446336feae0b2f280b61
https://doi.org/10.1158/1535-7163.22500156.v1
https://doi.org/10.1158/1535-7163.22500156.v1
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Fan Lin, Martin van der Valk, Els Wagenaar, Evita van de Steeg, Anita van Esch, Ahmed Elbatsh, Marion Ludwig, Dilek Iusuf
Organic anion-transporting polypeptides (OATP) mediate the hepatic uptake of many drugs, thus codetermining their clearance. Impaired hepatic clearance due to low-activity polymorphisms in human OATP1B1 may increase systemic exposure to SN-38, the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7919a874f439756c790a463f50f88691
https://doi.org/10.1158/1535-7163.c.6536373.v1
https://doi.org/10.1158/1535-7163.c.6536373.v1
Purpose: Organic anion-transporting polypeptide (OATP) drug uptake transporters are thought to play an important role in drug pharmacokinetics and toxicokinetics. We aimed to determine the influence of the individual human OATP1B1, OATP1B3, and OATP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51395895b4130d22711ff2299ba77a1a
https://doi.org/10.1158/1078-0432.c.6521525.v1
https://doi.org/10.1158/1078-0432.c.6521525.v1
Autor:
Alfred H. Schinkel, Koen van de Wetering, Ronald P.J. Oude Elferink, Dirk R. de Waart, Olaf van Tellingen, Els Wagenaar, Anita van Esch, Zeliha Pala, Maria L.H. Vlaming
Supplementary Data from Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f991808ad4b3b0de26cc12b4cccdbc
https://doi.org/10.1158/1078-0432.22439856
https://doi.org/10.1158/1078-0432.22439856
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Koen van de Wetering, Els Wagenaar, Zeliha Pala, Anita van Esch, Maria L. H. Vlaming
Supplementary Table 3 from Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ffde04a5d0d12e54922271a7ffd34b
https://doi.org/10.1158/1535-7163.22484625.v1
https://doi.org/10.1158/1535-7163.22484625.v1
Autor:
Alfred H. Schinkel, Jos H. Beijnen, Els Wagenaar, Rolf W. Sparidans, Robert A.B. van Waterschoot, Jurjen S. Lagas
Supplementary Figure 2 from Breast Cancer Resistance Protein and P-glycoprotein Limit Sorafenib Brain Accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287e92252c06b008be8035efac97d3bf
https://doi.org/10.1158/1535-7163.22485128
https://doi.org/10.1158/1535-7163.22485128