Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Elpida Charalambous"'
Autor:
Stacey A. Cohen, Ming Yu, Kelsey Baker, Mary Redman, Chen Wu, Tai J. Heinzerling, Ralph M. Wirtz, Elpida Charalambous, George Pentheroudakis, Vassiliki Kotoula, Konstantine T. Kalogeras, George Fountzilas, William M. Grady
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-8 (2017)
Abstract Background The CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after treatment with adjuvant irinotecan-based chemotherapy. In this analysis, we determine whether CIMP status
Externí odkaz:
https://doaj.org/article/ce6a026baba1411ca058ebd7dc4f73cf
Autor:
Nicholas Mitsiades, Kenneth C. Anderson, Constantine S. Mitsiades, Paul G. Richardson, Peter O'Gorman, Martin Clynes, Leutz Buon, Teru Hideshima, Dharminder Chauhan, Nikhil C. Munshi, Noopur S. Raje, Emily Daskalaki, Elpida Charalambous, Douglas W. McMillin, Vassiliki Kotoula, Patrick J. Hayden, Melissa G. Ooi
Supplementary Data from Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a845c66dc7589f8466201841a601261
https://doi.org/10.1158/1078-0432.22439989
https://doi.org/10.1158/1078-0432.22439989
Autor:
Nicholas Mitsiades, Kenneth C. Anderson, Constantine S. Mitsiades, Paul G. Richardson, Peter O'Gorman, Martin Clynes, Leutz Buon, Teru Hideshima, Dharminder Chauhan, Nikhil C. Munshi, Noopur S. Raje, Emily Daskalaki, Elpida Charalambous, Douglas W. McMillin, Vassiliki Kotoula, Patrick J. Hayden, Melissa G. Ooi
Purpose: p53 is inactivated in many human malignancies through missense mutations or overexpression of the human homologue of Mdm2 (Hdm2), an E3 ubiquitin ligase that ubiquitinates p53, thereby promoting its proteasomal degradation. The cis-imidazoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728045ed524eeea6ccdefabb43cb52bf
https://doi.org/10.1158/1078-0432.c.6517366.v1
https://doi.org/10.1158/1078-0432.c.6517366.v1
Autor:
Triantafyllia Koletsa, Ioannis Kostopoulos, Elpida Charalambous, Barbara Christoforidou, Eleni Nenopoulou, Vassiliki Kotoula
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 7, Pp 687-696 (2008)
Herstatin (HST) is an alternatively spliced HER2 product with growth-inhibitory properties in experimental cancer systems. The role of HST in adult human tissues and disease remains unexplored. Here, we investigated HST expression at the mRNA and pro
Externí odkaz:
https://doaj.org/article/5ffcee157fd8457aa453625af7211baa
Autor:
Vassiliki Kotoula, Aggeliki Lyberopoulou, Kyriaki Papadopoulou, Elpida Charalambous, Zoi Alexopoulou, Chryssa Gakou, Sotiris Lakis, Eleftheria Tsolaki, Konstantinos Lilakos, George Fountzilas
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128818 (2015)
Massively parallel sequencing (MPS) holds promise for expanding cancer translational research and diagnostics. As yet, it has been applied on paraffin DNA (FFPE) with commercially available highly multiplexed gene panels (100s of DNA targets), while
Externí odkaz:
https://doaj.org/article/aee2dfaae82049d791365de507171c0d
Autor:
George Papaxoinis, Vassiliki Kotoula, Zoi Alexopoulou, Konstantine T Kalogeras, Flora Zagouri, Eleni Timotheadou, Helen Gogas, George Pentheroudakis, Christos Christodoulou, Angelos Koutras, Dimitrios Bafaloukos, Gerasimos Aravantinos, Pavlos Papakostas, Elpida Charalambous, Kyriaki Papadopoulou, Ioannis Varthalitis, Ioannis Efstratiou, Thomas Zaramboukas, Helen Patsea, Chrisoula D Scopa, Maria Skondra, Paris Kosmidis, Dimitrios Pectasides, George Fountzilas
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140293 (2015)
The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9) and kinase (exon 20) domains of this protein. The aim of the present study was to examine the role of different types of
Externí odkaz:
https://doaj.org/article/148d1ad876ed40fd8096f0ed1713fb3a
Autor:
Vassiliki Kotoula, Mattheos Bobos, Zoi Alexopoulou, Christos Papadimitriou, Kyriaki Papadopoulou, Elpida Charalambous, Eleftheria Tsolaki, Grigorios Xepapadakis, Irene Nicolaou, Irene Papaspirou, Gerasimos Aravantinos, Christos Christodoulou, Ioannis Efstratiou, Helen Gogas, George Fountzilas
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103707 (2014)
BACKGROUND: HER2 and TOP2A gene status are assessed for diagnostic and research purposes in breast cancer with fluorescence in situ hybridization (FISH). However, FISH probes do not target only the annotated gene, while chromosome 17 (chr17) is among
Externí odkaz:
https://doaj.org/article/1c97f2dd901546c7920fc2c29acc59b9
Autor:
Vassiliki Kotoula, Elpida Charalambous, Bart Biesmans, Andigoni Malousi, Eleni Vrettou, George Fountzilas, George Karkavelas
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7746 (2009)
BackgroundTesting for tumor specific mutations on routine formalin-fixed paraffin-embedded (FFPE) tissues may predict response to treatment in Medical Oncology and has already entered diagnostics, with KRAS mutation assessment as a paradigm. The high
Externí odkaz:
https://doaj.org/article/e241b17456aa4daf9e42a247a3ac19c2
Autor:
Georgios Pentheroudakis, Flora Zagouri, George Kouvatseas, Ioannis Tikas, Eleftheria Tsolaki, Dimitrios Pectasides, Pavlos Papakostas, Christos Christodoulou, Angelos Koutras, Mattheos Bobos, G. Fountzilas, PA Kosmidis, Elpida Charalambous, Georgios Lazaridis, Vasiliki Kotoula, Eleni Giannoulatou, Ioannis Efstratiou
Publikováno v:
Cancer Research. 77:P6-09
Background-aim: HER2-positive breast cancer (BC) features high rates of tumor infiltrating lymphocytes (TILs) and mutations (mut) in various genes, more frequently in TP53. We investigated associations between TILs and mutations in HER2-positive BC a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5d786f4636540e11b73c79d8ad2f2af
https://doi.org/10.1158/1538-7445.sabcs16-p6-09-07
https://doi.org/10.1158/1538-7445.sabcs16-p6-09-07
Autor:
George Papaxoinis, Konstantine T. Kalogeras, Vasiliki Kotoula, Epaminontas Samantas, Zoi Alexopoulou, Dimitrios Pectasides, George Fountzilas, Christos Dervenis, Kleo Papaparaskeva, Christos Agalianos, George Pentheroudakis, Chrysoula Gkakou, Elpida Charalambous
Publikováno v:
Anticancer Research. 36:6347-6356
Aim: The aim of this study was to evaluate the mRNA expression pattern of growth- and survival-related genes and assess their prognostic significance in patients with advanced pancreatic cancer. Patients and Methods: In total, 98 patients were includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d9cdfcf119e867ff5cfeaca73ba2fc
https://doi.org/10.21873/anticanres.11232
https://doi.org/10.21873/anticanres.11232