Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Elphine Telles"'
Autor:
Lei Sun, Caralina Marin de Evsikova, Ka Bian, Alexandra Achille, Elphine Telles, Huadong Pei, Edward Seto
Publikováno v:
EBioMedicine, Vol 33, Iss , Pp 157-168 (2018)
Histone deacetylases (HDACs) are enzymes that regulate protein functions by catalyzing the removal of acetyl and acyl groups from lysine residues. They play pivotal roles in governing cell behaviors and are indispensable in numerous biological proces
Externí odkaz:
https://doaj.org/article/bc7cf07b8bf941a3a6bb0f842ecdd4a0
Autor:
Huadong Pei, Elphine Telles, Caralina Marin de Evsikova, Alexandra Achille, Ka Bian, Edward Seto, Lei Sun
Publikováno v:
EBioMedicine
EBioMedicine, Vol 33, Iss, Pp 157-168 (2018)
EBioMedicine, Vol 33, Iss, Pp 157-168 (2018)
Histone deacetylases (HDACs) are enzymes that regulate protein functions by catalyzing the removal of acetyl and acyl groups from lysine residues. They play pivotal roles in governing cell behaviors and are indispensable in numerous biological proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1c9f6870f36ebd0f7f716fcab4ac07
https://pubmed.ncbi.nlm.nih.gov/29958910
https://pubmed.ncbi.nlm.nih.gov/29958910
Significance StatementObesity is a serious and widespread health problem which has become a growing concern in many societies. Most currently available weight-loss medications do not work for everyone, and the effects decline over time. Thus, there i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf7018c4c012c5d241a2ca955b998b4
Autor:
Eduardo M. Sotomayor, Elphine Telles, Noreen Luetteke, Edward Seto, Lei Sun, Fengdong Cheng, Molly Karl, Robert H. Miller
Publikováno v:
Life Science Alliance
In an animal model for multiple sclerosis, the absence of HDAC11 reduces clinical severity, spinal cord demyelination, and immune cell infiltration, suggesting that HDAC11 is a promising target for MS treatment.
Multiple sclerosis (MS) is a chro
Multiple sclerosis (MS) is a chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bad4bef8c5dd696b0fe70bfe5eb41b
https://pubmed.ncbi.nlm.nih.gov/30456376
https://pubmed.ncbi.nlm.nih.gov/30456376
Autor:
Xiaohong Zhang, Rangasudhagar Radhakrishnan, Shengyan Xiang, Zhigang Yuan, Elphine Telles, David Shibata, Domenico Coppola, William S. Lane, Edward Seto, Fenghua Yuan, Yanbin Zhang, Yixuan Li, Jia Fang
Publikováno v:
Journal of Biological Chemistry. 290:22795-22804
MutS homolog 2 (MSH2) is an essential DNA mismatch repair (MMR) protein. It interacts with MSH6 or MSH3 to form the MutSα or MutSβ complex, respectively, which recognize base-base mispairs and insertions/deletions and initiate the repair process. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a064eebaca21e9c4d697c8ac95742d79
https://doi.org/10.1074/jbc.m114.612945
https://doi.org/10.1074/jbc.m114.612945
Publikováno v:
Experimental Cell Research. 315:1448-1457
Mitotic progression requires the activity of the dual specificity phosphatase, cdc25C. Cdc25C function is inhibited by complex formation with two 14-3-3 isoforms, 14-3-3epsilon and 14-3-3gamma. To understand the molecular basis of specific complex fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352c5dfe73ce25138788a2adf674ec21
https://doi.org/10.1016/j.yexcr.2009.01.018
https://doi.org/10.1016/j.yexcr.2009.01.018
Publikováno v:
Cell cycle (Georgetown, Tex.). 10(5)
The activity of the dual specificity phosphatase cdc25C is required for mitotic progression though the mechanisms by which cdc25C is activated prior to mitosis in human cells remain unclear. The data presented herein show that the actin binding prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3903691bb944dce70a66e025953e46
https://pubmed.ncbi.nlm.nih.gov/21325883
https://pubmed.ncbi.nlm.nih.gov/21325883
Publikováno v:
Cancer Research. 73:1742-1742
Histone deacetylases (HDACs) are enzymes that deacetylate lysine residues on histone and non-histone proteins. They regulate various cellular functions including transcriptional regulation, cell proliferation, apoptosis, and cellular metabolism. Broa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d6038fb3221f605674d010c30e1d66
https://doi.org/10.1158/1538-7445.am2013-1742
https://doi.org/10.1158/1538-7445.am2013-1742
Autor:
Lirong Peng, Fengdong Cheng, David M. Woods, Lianet Vazquez, Elphine Telles, Yu Yu, Xue-Zhong Yu, Eva Sahakian, Alejandro Villagra, Hongwei Wang, Liqing Wang, Wayne W. Hancock, Bruce R. Blazar, Edward Seto, Noreen Luetteke, Dapeng Wang, Eduardo M. Sotomayor, Zi Wang, Karrune Woan, Javier Pinilla
Publikováno v:
ResearcherID
Abstract 359FN2 T-cells are an essential component of immune mediated tumor rejection. Adoptive transfer of T-cells has resulted in durable antitumor responses in some patients with hematologic malignancies. Further improvement in the efficacy of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d3c2096897d09c7ccc6ba9854824bf
https://doi.org/10.1182/blood.v118.21.359.359
https://doi.org/10.1182/blood.v118.21.359.359
Autor:
Xue-Zhong Yu, Yu Yu, Lirong Peng, Kenrick Semple, Dapeng Wang, Eduardo M. Sotomayor, Claudio Anasetti, Fengdong Cheng, Noreen Luetteke, Elphine Telles, Edward Seto
Publikováno v:
Blood. 116:1466-1466
Abstract 1466 Background: Histone acetyltransferases and histone deacetylases (HDAC) regulate gene expression through acetylation-deacetylation of histones. HDACs are the target of a family of compounds known as HDAC inhibitors, which have been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6b73582f1433341aa8b55e033181432
https://doi.org/10.1182/blood.v116.21.1466.1466
https://doi.org/10.1182/blood.v116.21.1466.1466