Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elorm J Agra"'
Autor:
Kirthana Sreerangathama Suresh, Qi He, Robert A. Guyton, Muralidhar Padala, Daisuke Onohara, Elorm J Agra
Publikováno v:
ASAIO J
OBJECTIVE: Functional mitral regurgitation in the setting of an enlarged heart is challenging to repair surgically with an annular approach, and the need to develop sub-annular and ventricular approaches is recognized yet unrealized due to the lack o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415fbb324b9b890018a194c7d590bc10
https://doi.org/10.1097/mat.0000000000001145
https://doi.org/10.1097/mat.0000000000001145
Autor:
Jyotsna Mishra, Elorm J. Agra, Junhui Sun, Suresh K. Joseph, Caitlin Vail, Shey-Shing Sheu, Elizabeth Murphy, Celia Fernandez-Sanz, Dewight Williams, Sergio de la Fuente, Kira M. Holmström, Toren Finkel, György Csordás
Publikováno v:
Journal of Biological Chemistry. 291:23343-23362
Control of myocardial energetics by Ca2+ signal propagation to the mitochondrial matrix includes local Ca2+ delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) to the inner mitochondrial membrane (IMM) Ca2+ uniporter (mtCU). mtCU act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4837042d002c8a496f2733c90475f54f
https://doi.org/10.1074/jbc.m116.755496
https://doi.org/10.1074/jbc.m116.755496
Autor:
Neil Zalavadia, Shavonn C. Smith, Sadia Mohsin, Remus M. Berretta, Yan Zhou, Jason M. Duran, Thomas E. Sharp, Timothy Starosta, Hajime Kubo, Steven R. Houser, Constantine D Troupes, Elorm J Agra
Publikováno v:
Circulation Research. 117:1024-1033
Rationale: Adoptive transfer of multiple stem cell types has only had modest effects on the structure and function of failing human hearts. Despite increasing the use of stem cell therapies, consensus on the optimal stem cell type is not adequately d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e383efef977bb8c6a80296022f5c600
https://doi.org/10.1161/circresaha.115.307362
https://doi.org/10.1161/circresaha.115.307362
Publikováno v:
Journal of the American College of Cardiology. 74:B439
The need for clinically relevant experimental platforms of functional mitral regurgitation (FMR) are necessary to test new transcatheter mitral valve devices. Isolated mitral valve models of FMR have been reported previously, but they lack a left ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9df7b79fa739daaf7e75378076421131
https://doi.org/10.1016/j.jacc.2019.08.1006
https://doi.org/10.1016/j.jacc.2019.08.1006
Autor:
Sadia Mohsin, Constantine D Troupes, Thomas E Sharp, Timothy Starosta, Elorm J Agra, Shavon Smith, Hajime Kubo, Remus M Berretta, Steven R Houser
Publikováno v:
Circulation Research. 117
Rationale: Adoptive transfer of bone marrow and cardiac derived stem cells (CDCs) into failing human hearts has been shown to be safe, yet these cells have only induced modest improvements after myocardial infarction (MI). Recently we have shown in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a223a5b100e79e00e937ea84cce5424
https://doi.org/10.1161/res.117.suppl_1.157
https://doi.org/10.1161/res.117.suppl_1.157
Autor:
Sergio de la Fuente, Caitlin Vail, Elorm J Agra, Kira Holmstrom, Junhui Sun, Jyotsna Mishra, Toren Finkel, Elizabeth Murphy, Shey-Shing Sheu, Gyorgy Csordas
Publikováno v:
Circulation Research. 117
Propagation of SR-derived Ca2+ signals to the mitochondrial matrix is an important tuning tool of cardiac energy metabolism (excitation-bioenergetics coupling). Effective activation of the low-affinity mitochondrial Ca2+ uniporter (mtCU) is supported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c5fbcec7123a8fa48942f16c2c9a3bc
https://doi.org/10.1161/res.117.suppl_1.240
https://doi.org/10.1161/res.117.suppl_1.240
Autor:
Caitlin Vail, Toren Finkel, Kira M. Holmström, Elorm J. Agra, Junhui Sun, Suresh K. Joseph, Jyotsna Mishra, Elisabeth Murphy, Sergio de la Fuente, György Csordás, Shey-Shing Sheu
Publikováno v:
Biophysical Journal. 110:312a
The bioenergetic fueling of cardiac muscle activity is tuned by Ca2+ signals propagated from SR to the mitochondrial matrix (excitation-bioenergetics coupling). Effective activation of the low-affinity mitochondrial Ca2+ uniporter (mtCU) is promoted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3f160ed4cd0b5cb1b10f0fcc43fcdc
https://doi.org/10.1016/j.bpj.2015.11.1673
https://doi.org/10.1016/j.bpj.2015.11.1673