Výsledky vyhledávání - "Eloise Thompson"

Akademický článek

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission.

Autor: Ghania Ramdani, Bernina Naissant, Eloise Thompson, Florence Breil, Audrey Lorthiois, Florian Dupuy, Ross Cummings, Yoann Duffier, Yolanda Corbett, Odile Mercereau-Puijalon, Kenneth Vernick, Donatella Taramelli, David A Baker, Gordon Langsley, Catherine Lavazec

Publikováno v: PLoS Pathogens, Vol 11, Iss 5, p e1004815 (2015)

Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and a

Externí odkaz: https://doaj.org/article/03e94455a91049aea358d495affa9184

Zobrazit plný text záznamu

Akademický článek

Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress.

Autor: Jeong Joo Kim, Christian Flueck, Eugen Franz, Eduardo Sanabria-Figueroa, Eloise Thompson, Robin Lorenz, Daniela Bertinetti, David A Baker, Friedrich W Herberg, Choel Kim

Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004639 (2015)

The Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) is a key regulator across the malaria parasite life cycle. Little is known about PfPKG's activation mechanism. Here we report that the carboxyl cyclic nucleotide binding domain functions

Externí odkaz: https://doaj.org/article/cdf948dfee564831ba47e158adaa23ca

Zobrazit plný text záznamu

Akademický článek

Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites.

Autor: Mathieu Brochet, Mark O Collins, Terry K Smith, Eloise Thompson, Sarah Sebastian, Katrin Volkmann, Frank Schwach, Lia Chappell, Ana Rita Gomes, Matthew Berriman, Julian C Rayner, David A Baker, Jyoti Choudhary, Oliver Billker

Publikováno v: PLoS Biology, Vol 12, Iss 3, p e1001806 (2014)

Many critical events in the Plasmodium life cycle rely on the controlled release of Ca²⁺ from intracellular stores to activate stage-specific Ca²⁺-dependent protein kinases. Using the motility of Plasmodium berghei ookinetes as a signalling par

Externí odkaz: https://doaj.org/article/2e9ff0eabae14cb39898e2aeb02503e0

Zobrazit plný text záznamu

Akademický článek

A nationwide survey of the quality of antimalarials in retail outlets in Tanzania.

Autor: Harparkash Kaur, Catherine Goodman, Eloise Thompson, Katy-Anne Thompson, Irene Masanja, S Patrick Kachur, Salim Abdulla

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3403 (2008)

Retail pharmaceutical products are commonly used to treat fever and malaria in sub-Saharan African countries. Small scale studies have suggested that poor quality antimalarials are widespread throughout the region, but nationwide data are not availab

Externí odkaz: https://doaj.org/article/9c477d91178c40a4bca958d917a27830

Zobrazit plný text záznamu

Validity and reliability of a smartphone inclinometer app for measuring passive upper limb range of motion in a stroke population*

Autor: Natasha A. Lannin, Eloise Thompson, Kate D’Cruz, Natalie Chew Jin Lin, Xia Li, Kathryn S Hayward

Publikováno v: Disability and Rehabilitation. 42:3243-3249

Purpose: To demonstrate the validity and reliability of a smartphone app to measure ROM after stroke.Materials and methods: Twenty-one stroke survivors with a diagnosis of stroke that affected the ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda7ef5fadf3a32db325d1b3f3ee4ff4
https://doi.org/10.1080/09638288.2019.1585972

Zobrazit plný text záznamu

Indolone-N-oxide derivatives: in vitro activity against fresh clinical isolates of Plasmodium falciparum, stage specificity and in vitro interactions with established antimalarial drugs

Autor: Eloise Thompson, Françoise Nepveu, Hany Ibrahim, Jeremie Boyer, Livia Vivas, Leonardo K. Basco, Rachida Tahar

Publikováno v: Journal of Antimicrobial Chemotherapy. 66:2566-2572

OBJECTIVES Indolone-N-oxides are characterized by the presence of a highly reactive pharmacophore, the nitrone moiety (C=N(+)-O(-)), which undergoes oxidation-reduction reactions. The aims of the present study were to: (i) evaluate the in vitro activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bee795523c55f96a1245ccdf64e0fa7
https://doi.org/10.1093/jac/dkr320

Zobrazit plný text záznamu

Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives

Publikováno v: Journal of Medicinal Chemistry. 53:699-714

A series of 66 new indolone-N-oxide derivatives was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016948cfbe2fa31eee11a8d2bc93427d
https://doi.org/10.1021/jm901300d

Zobrazit plný text záznamu

An evaluation of Lincolnshire's telecare service

Autor: Eloise Thompson, Alex Newton, Deborah Shepherd

Publikováno v: Journal of Assistive Technologies. 2:48-51

The main aim of the evaluation was to identify the strengths and weaknesses of the service in order to contribute to its further development and sustainability. The study was carried out in partnership between Lincolnshire Adult Social Care and Linco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14bc9e6fa1b2defee8575ffc561c134b
https://doi.org/10.1108/17549450200800018

Zobrazit plný text záznamu

Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress

Autor: Friedrich W. Herberg, Eugen Franz, Robin Lorenz, Daniela Bertinetti, Eduardo Sanabria-Figueroa, Eloise Thompson, Choel Kim, David A. Baker, Jeong Joo Kim, Christian Flueck

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 11, Iss 2, p e1004639 (2015)

The Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) is a key regulator across the malaria parasite life cycle. Little is known about PfPKG’s activation mechanism. Here we report that the carboxyl cyclic nucleotide binding domain functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874321c2afb0c91423d3f0d80eefe0e9
https://researchonline.lshtm.ac.uk/id/eprint/2138365/1/ppat.1004639.pdf

Zobrazit plný text záznamu

The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2 modulates in vitro parasite response to artemisinin and quinine

Autor: Gisela, Henriques, Donelly A, van Schalkwyk, Rebekah, Burrow, David C, Warhurst, Eloise, Thompson, David A, Baker, David A, Fidock, Rachel, Hallett, Christian, Flueck, Colin J, Sutherland

Publikováno v: Antimicrobial Agents and Chemotherapy

The emergence of drug-resistant parasites is a serious threat faced by malaria control programs. Understanding the genetic basis of resistance is critical to the success of treatment and intervention strategies. A novel locus associated with antimala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1c3c7418990300f297c71bc94d95b84
https://pubmed.ncbi.nlm.nih.gov/25691625

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání