Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Eloise Mastrangelo"'
Autor:
Andrea Balboni, Camilla D’Angelo, Nicoletta Collura, Simone Brusco, Claudia Di Berardino, Altea Targa, Beatrice Massoti, Eloise Mastrangelo, Mario Milani, Pierfausto Seneci, Vania Broccoli, Luca Muzio, Rossella Galli, Andrea Menegon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Glioblastoma (GBM) is the most common malignant primary brain cancer that, despite recent advances in the understanding of its pathogenesis, remains incurable. GBM contains a subpopulation of cells with stem cell-like properties called cance
Externí odkaz:
https://doaj.org/article/d2425d752d414824a5eee89bb1c78547
Autor:
Elisa Fagnani, Francesco Bonì, Pierfausto Seneci, Davide Gornati, Luca Muzio, Eloise Mastrangelo, Mario Milani
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1088-1093 (2024)
The stabilization of the retromer protein complex can be effective in the treatment of different neurological disorders. Following the identification of bis-1,3-phenyl guanylhydrazone 2a as an effective new compound for the treatment of amyotrophic l
Externí odkaz:
https://doaj.org/article/1cd32817805240faa098c6e2c29a04ba
Autor:
Michela Bollati, Luisa Diomede, Toni Giorgino, Carmina Natale, Elisa Fagnani, Irene Boniardi, Alberto Barbiroli, Rebecca Alemani, Marten Beeg, Marco Gobbi, Ana Fakin, Eloise Mastrangelo, Mario Milani, Gianluca Presciuttini, Edi Gabellieri, Patrizia Cioni, Matteo de Rosa
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6355-6365 (2021)
Gelsolin comprises six homologous domains, named G1 to G6. Single point substitutions in this protein are responsible for AGel amyloidosis, a hereditary disease causing progressive corneal lattice dystrophy, cutis laxa, and polyneuropathy. Although s
Externí odkaz:
https://doaj.org/article/28c0fa7cd36a48168031138ec41efe6d
Autor:
Federica Cossu, Simone Camelliti, Daniele Lecis, Luca Sorrentino, Maria Teresa Majorini, Mario Milani, Eloise Mastrangelo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6366-6374 (2021)
Inhibitors of apoptosis proteins (IAPs) are validated onco-targets, as their overexpression correlates with cancer onset, progression, diffusion and chemoresistance. IAPs regulate cell death survival pathways, inflammation, and immunity. Targeting IA
Externí odkaz:
https://doaj.org/article/c86117b4d2eb46419e5f2244e91de453
Autor:
Luca Muzio, Riccardo Sirtori, Davide Gornati, Simona Eleuteri, Andrea Fossaghi, Diego Brancaccio, Leonardo Manzoni, Linda Ottoboni, Luca De Feo, Angelo Quattrini, Eloise Mastrangelo, Luca Sorrentino, Emanuele Scalone, Giancarlo Comi, Luciana Marinelli, Nilo Riva, Mario Milani, Pierfausto Seneci, Gianvito Martino
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer sta
Externí odkaz:
https://doaj.org/article/2a79c2c4685b4d2598d773092d995d7b
Autor:
Michele Fiore, Michele Mosconi, Francesco Bonì, Alice Parodi, Annalisa Salis, Bruno Tasso, Eloise Mastrangelo, Enrico Millo, Federica Cossu
Publikováno v:
Molecules, Vol 28, Iss 1, p 446 (2023)
Inhibitor of Apoptosis Proteins (IAPs) are validated targets for cancer therapy, and the deregulation of their activities within the NF-κB pathway correlates with chemoresistance events, even after treatment with IAPs-antagonists in the clinic (Smac
Externí odkaz:
https://doaj.org/article/29fc0bce5e904e8f953a500626187fa6
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 142-150 (2019)
Inhibitor of apoptosis (IAP) proteins are characterized by the presence of the conserved baculoviral IAP repeat (BIR) domain that is involved in protein-protein interactions. IAPs were initially thought to be mainly responsible for caspase inhibition
Externí odkaz:
https://doaj.org/article/a49b239055ab4b7fbdbc4629d2c536c6
Autor:
Rafaela Milan Bonotto, Francesco Bonì, Mario Milani, Antonio Chaves-Sanjuan, Silvia Franze, Francesca Selmin, Tommaso Felicetti, Martino Bolognesi, Soultana Konstantinidou, Monica Poggianella, Chantal L. Márquez, Federica Dattola, Monica Zoppè, Giuseppe Manfroni, Eloise Mastrangelo, Alessandro Marcello
Publikováno v:
Viruses, Vol 14, Iss 6, p 1157 (2022)
Pyridobenzothiazolone derivatives are a promising class of broad-spectrum antivirals. However, the mode of action of these compounds remains poorly understood. The HeE1-17Y derivative has already been shown to be a potent compound against a variety o
Externí odkaz:
https://doaj.org/article/b90d49d34ce949a9a2ae978d6def6752
Autor:
Ilaria Caracciolo, Erick Mora-Cardenas, Chiara Aloise, Tea Carletti, Ludovica Segat, Maria Sole Burali, Alexsia Chiarvesio, Vivianna Totis, Tatjana Avšič-Županc, Eloise Mastrangelo, Giuseppe Manfroni, Pierlanfranco D'Agaro, Alessandro Marcello
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008156 (2020)
Surveillance of Usutu virus is crucial to prevent future outbreaks both in Europe and in other countries currently naïve to the infection, such as the Americas. This goal remains difficult to achieve, notably because of the lack of large-scale cohor
Externí odkaz:
https://doaj.org/article/bfa4b3db245a48a79fde3925293fea19
Autor:
Jana Van Dycke, Michela Puxeddu, Giuseppe La Regina, Eloise Mastrangelo, Delia Tarantino, Jasper Rymenants, Jessica Sebastiani, Marianna Nalli, Jelle Matthijnssens, Johan Neyts, Romano Silvestri, Joana Rocha-Pereira
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1006 (2021)
Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting in ~219,000 deaths annually and a societal cost of ~USD60 billion. There are no antivirals or vaccines available to treat and/or prevent HuNoV. In this study, we
Externí odkaz:
https://doaj.org/article/67a5e148492f472c90bbc00a58b6c0e3