Pentraxin 3 regulates neutrophil infiltration to the brain during neuroinflammation [version 1; peer review: 2 approved]

Autor: Ivana Rajkovic, Eloise Lemarchand, Raymond Wong, Stuart M. Allan, Rory Tinker, Emmanuel Pinteaux

Publikováno v: AMRC Open Research, Vol 1 (2019)

Introduction: The acute phase protein pentraxin 3 (PTX3) is known for its anti-inflammatory effects through downregulating neutrophil transmigration during peripheral inflammation. Furthermore, we have previously demonstrated a neuroprotective and ne

Externí odkaz: https://doaj.org/article/2eef2ec1e071449d85b6a5c7911d64e8

LRRC8A is dispensable for a variety of microglial functions and response to acute stroke

Autor: James R. Cook, Anna L. Gray, Eloise Lemarchand, Ingo Schiessl, Jack P. Green, Mary C. Newland, Douglas P. Dyer, David Brough, Catherine B. Lawrence

Publikováno v: Cook, J R, Gray, A L, Lemarchand, E, Schiessl, I, Green, J P, Newland, M C, Dyer, D P, Brough, D & Lawrence, C B 2022, ' LRRC8A is dispensable for a variety of microglial functions and response to acute stroke ', GLIA . https://doi.org/10.1002/glia.24156

Microglia, resident brain immune cells, are critical in orchestrating responses to central nervous system (CNS) injury. Many microglial functions, such as phagocytosis, motility and chemotaxis, are suggested to rely on chloride channels, including th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9270316a734626ab3f952f6f0f2119f0
https://doi.org/10.1002/glia.24156

Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption

Autor: Zahraa S. Al-Ahmady, Ben R. Dickie, Isabelle Aldred, Dhifaf A. Jasim, Jack Barrington, Michael Haley, Eloise Lemarchand, Graham Coutts, Satinderdeep Kaur, Jessica Bates, Sarah Curran, Ruth Goddard, Megan Walker, Adrian Parry-jones, Kostas Kostarelos, Stuart M. Allan

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Kostarelos, K, Al-Ahmady, Z S, Dickie, B, Aldred, I, Jasim, D, Barrington, J, Haley, M, Lemarchand, E, Coutts, G, Kaur, S, Bates, J, Curran, S, Goddard, R, Walker, M & Parry-Jones, A 2022, ' Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption ', Theranostics, vol. 12, no. 10, 10, pp. 4477-4497 . https://doi.org/10.7150/thno.72167

Haemorrhagic stroke represents a significant public health burden, yet our knowledge and ability to treat this type of stroke are lacking. Previously we showed that we can target ischaemic-stroke lesions by selective translocation of lipid nanopartic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248cb0f9c65c702e45847e9a3c74ce66
http://hdl.handle.net/10261/280759

Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice

Autor: Michael J. Haley, Stuart M. Allan, Conor O'Boyle, Joanne E. Konkel, Eloise Lemarchand, Catherine B. Lawrence, Craig J. Smith

Publikováno v: O'Boyle, C, Haley, M J, Lemarchand, E, Smith, C J, Allan, S M, Konkel, J E & Lawrence, C B 2019, ' Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice ', International Journal of Stroke . https://doi.org/10.1177/1747493019834191
International Journal of Stroke

Background Stroke is a major cause of disability and mortality. Poorer outcome after stroke is associated with concomitant inflammatory and infectious disease. Periodontitis is a chronic inflammatory disease of the dental supporting structures and is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f1475f5262ce71ed0d486b40928894
https://doi.org/10.1177/1747493019834191

Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture

Autor: Elena Redondo-Castro, David Brough, Christopher Hoyle, James Cook, Eloise Lemarchand, Te-Chen Tzeng, Stuart M. Allan

Publikováno v: Hoyle, C, Redondo Castro, E, Cook, J, Tzeng, T-C, Allan, S, Brough, D & Lemarchand, E 2020, ' Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture ', Immunology, vol. 161, no. 1, pp. 39-52 . https://doi.org/10.1111/imm.13221
Immunology

Summary Microglial inflammation driven by the NACHT, LRR and PYD domain‐containing protein 3 (NLRP3) inflammasome contributes to brain disease and is a therapeutic target. Most mechanistic studies on NLRP3 activation use two‐dimensional pure micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf53cb5354148a2af6c68490b7b07fb
https://www.research.manchester.ac.uk/portal/en/publications/hallmarks-of-nlrp3-inflammasome-activation-are-observed-in-organotypic-hippocampal-slice-culture(0d68d1c9-185c-45bd-94b1-af5c70188fc4).html