Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Eloise, Hudry"'
Autor:
Ellie M. Carrell, Yong Hong Chen, Paul T. Ranum, Stephanie L. Coffin, Larry N. Singh, Luis Tecedor, Megan S. Keiser, Eloise Hudry, Bradley T. Hyman, Beverly L. Davidson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 296-304 (2023)
Recombinant adeno-associated viral vectors (rAAVs) are a promising strategy to treat neurodegenerative diseases because of their ability to infect non-dividing cells and confer long-term transgene expression. Despite an ever-growing library of capsid
Externí odkaz:
https://doaj.org/article/adb40a4cec5b4a3d9ab912e739f69a5c
Autor:
Eric W. Johnson, Jeffrey J. Sutherland, Emily Meseck, Cameron McElroy, Deepa H. Chand, Francis Fonyuy Tukov, Eloise Hudry, Kelley Penraat
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 208-219 (2023)
In nonhuman primates (NHPs), adeno-associated virus serotype 9 (AAV9) vectorized gene therapy can cause asymptomatic microscopic injury to dorsal root ganglia (DRG) and trigeminal ganglia (TG) somatosensory neurons, causing neurofilament light chain
Externí odkaz:
https://doaj.org/article/ff357e0c44fd444d815f1c28922732c0
Autor:
Raquel Larramona-Arcas, Candela González-Arias, Gertrudis Perea, Antonia Gutiérrez, Javier Vitorica, Tamara García-Barrera, José Luis Gómez-Ariza, Raquel Pascua-Maestro, María Dolores Ganfornina, Eleanna Kara, Eloise Hudry, Marta Martinez-Vicente, Miquel Vila, Elena Galea, Roser Masgrau
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Abstract Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alz
Externí odkaz:
https://doaj.org/article/d54845f1ed0141cba4bad31da880a522
Autor:
Maria Calvo-Rodriguez, Steven S. Hou, Austin C. Snyder, Elizabeth K. Kharitonova, Alyssa N. Russ, Sudeshna Das, Zhanyun Fan, Alona Muzikansky, Monica Garcia-Alloza, Alberto Serrano-Pozo, Eloise Hudry, Brian J. Bacskai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Calvo-Rodriguez et al. show elevated calcium levels in neuronal mitochondria in a mouse model of cerebral β-amyloidosis after plaque deposition, which precede rare neuron death events in this model. The mechanism involves toxic extracellular Aβ oli
Externí odkaz:
https://doaj.org/article/638a348449c44bb59f38a1bc9201bb6b
Autor:
Shilpa Prabhakar, Pike See Cheah, Xuan Zhang, Max Zinter, Maria Gianatasio, Eloise Hudry, Roderick T. Bronson, David J. Kwiatkowski, Anat Stemmer-Rachamimov, Casey A. Maguire, Miguel Sena-Esteves, Bakhos A. Tannous, Xandra O. Breakefield
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 18-26 (2019)
Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome caused by mutations in TSC1 or TSC2, encoding hamartin and tuberin, respectively. These proteins act as a complex that inhibits mammalian target of rapamycin (mTOR)-mediated cell growth
Externí odkaz:
https://doaj.org/article/5011cb5ccfc6461d9959126df3595260
Autor:
Killian S. Hanlon, Jonah C. Meltzer, Tetyana Buzhdygan, Ming J. Cheng, Miguel Sena-Esteves, Rachel E. Bennett, Timothy P. Sullivan, Roshanak Razmpour, Yi Gong, Carrie Ng, Josette Nammour, Daniela Maiz, Simon Dujardin, Servio H. Ramirez, Eloise Hudry, Casey A. Maguire
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 320-332 (2019)
Adeno-associated virus (AAV) capsid libraries have generated improved transgene delivery vectors. We designed an AAV library construct, iTransduce, that combines a peptide library on the AAV9 capsid with a Cre cassette to enable sensitive detection o
Externí odkaz:
https://doaj.org/article/52e01ca87cb94b9eaa2bbaf0a5e3ec5e
Autor:
Ana Claudia Amaral, Beatriz G. Perez-Nievas, Michael Siao Tick Chong, Alicia Gonzalez-Martinez, Herminia Argente-Escrig, Sara Rubio-Guerra, Caitlin Commins, Serra Muftu, Bahareh Eftekharzadeh, Eloise Hudry, Zhanyun Fan, Prianca Ramanan, Shuko Takeda, Matthew P. Frosch, Susanne Wegmann, Teresa Gomez-Isla
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102058- (2021)
Summary: It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer
Externí odkaz:
https://doaj.org/article/0834daf1f0d14cb1bd40b2f5ea69e654
Autor:
Eloise Hudry, Eva Andres-Mateos, Eli P. Lerner, Adrienn Volak, Olivia Cohen, Bradley T. Hyman, Casey A. Maguire, Luk H. Vandenberghe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 197-209 (2018)
Adeno-associated viral vectors (AAVs) have demonstrated potential in applications for neurologic disorders, and the discovery that some AAVs can cross the blood-brain barrier (BBB) after intravenous injection has further expanded these opportunities
Externí odkaz:
https://doaj.org/article/7a18b8c93c6f48f5bb927acaec2fa9aa
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
The physiological function of the neurovascular unit is critically dependent upon the complex structure and functions of astrocytes for optimal preservation of cerebral homeostasis. While it has been shown that astrocytes exhibit aberrant changes in
Externí odkaz:
https://doaj.org/article/f21b8c2add2a4781b518379277988c21
Autor:
Alberto, Serrano-Pozo, Zhaozhi, Li, Ayush, Noori, Huong N, Nguyen, Aziz, Mezlini, Liang, Li, Eloise, Hudry, Rosemary J, Jackson, Bradley T, Hyman, Sudeshna, Das
Publikováno v:
Nat Aging
The roles of APOEε4 and APOEε2—the strongest genetic risk and protective factors for Alzheimer’s disease—in glial responses remain elusive. We tested the hypothesis that APOE alleles differentially impact glial responses by investigating thei