Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eloisa Jimenez‐Nunez"'
Autor:
Tobias Schmelzle, Emilie Chapeau, Daniel Bauer, Patrick Chene, Jason Faris, Cesar Fernandez, Pascal Furet, Giorgio Galli, Jiachang Gong, Stephanie Harlfinger, Francesco Hofmann, Eloisa Jimenez Nunez, Joerg Kallen, Thanos Mourikis, Laurent Sansregret, Paulo Santos, Clemens Scheufler, Holger Sellner, Markus Voegtle, Markus Wartmann, Peter Wessels, Frederic Zecri, Nicolas Soldermann
Publikováno v:
Cancer Research. 83:LB319-LB319
The YAP-TEAD protein-protein interaction (PPI) is a critical event known to mediate YAP oncogenic functions downstream of the Hippo pathway. Current advanced pharmacological agents which aim at inhibiting YAP-TEAD oncogenic function do so by engaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad77e2db1f0369ac9729c839360bd713
https://doi.org/10.1158/1538-7445.am2023-lb319
https://doi.org/10.1158/1538-7445.am2023-lb319
Autor:
Saskia M. Brachmann, Andreas Weiss, Daniel A. Guthy, Kim Beyer, Johannes Voshol, Michel Maira, Anirudh Prahallad, Diana Graus Porta, Christian Schnell, Nils Ostermann, Andrea Vaupel, Marc Gerspacher, Catherine Leblanc, Dirk Erdmann, Dario Sterker, Grainne Kerr, Giovannoni Jerome, Victoria Head, Rowan Stringer, Ruben De Kanter, Kearns Jeff, Danielle Roman, Toni Widmer, Peter Wessels, Eloisa Jimenez Nunez, Richard Sedrani, Frederic Zecri, Francesco Hofmann, Jeff Engleman, Edwige Lorthiois, Simona Cotesta
Publikováno v:
Molecular Cancer Therapeutics. 20:P124-P124
RAS is the most frequently mutated oncogene in cancer. KRAS G12C mutations are most prevalent in lung adenocarcinoma (~13%) and colorectal adenocarcinoma (~4%), and occur less commonly in other solid tumor malignancies. First generation KRASG12C inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad4b8e929a5d91731e7278c2de32193c
https://doi.org/10.1158/1535-7163.targ-21-p124
https://doi.org/10.1158/1535-7163.targ-21-p124
Publikováno v:
Topics in Catalysis. 53:924-930
Reactions of 1,6-enynes catalyzed by gold(I) complexes usually proceed stereospecifically through highly distorted cyclopropyl gold carbenes. Substrates with an alkoxy substituent at the propargylic position undergo stereoselective transformations th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6e0ec447245f92d31eb8bcef6a46f44
https://doi.org/10.1007/s11244-010-9524-6
https://doi.org/10.1007/s11244-010-9524-6
Publikováno v:
Chemical Reviews. 108:3326-3350
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b92a0212a0e6ebb05dbfc5fbb23a576
https://doi.org/10.1021/cr0684319
https://doi.org/10.1021/cr0684319
Publikováno v:
European Journal of Organic Chemistry. 2007:4217-4223
Skeletal rearrangements of simple 1,6-enynes have been studied in order to determine the factors that control the formation of five- or six-membered rings. Simple 1,6-enynes substituted only at C-4 preferentially give six-membered rings on skeletal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f50294c277f8506451761a660c88000a
https://doi.org/10.1002/ejoc.200700402
https://doi.org/10.1002/ejoc.200700402
Publikováno v:
Chem. Commun.. :333-346
In this feature article we cover most recent efforts in gold-catalysed transformations, highlighting the wide molecular diversity that can be achieved, in particular with regard to the formation of C–C bonds. Mechanistic interpretations of some cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ba4e42a28720b8529777716c384458
https://doi.org/10.1039/b612008c
https://doi.org/10.1039/b612008c
Autor:
Antonio M. Echavarren, Cristina Nieto-Oberhuber, Eloisa Jimenez‐Nunez, Diego J. Cárdenas, Salomé López, M. Paz Muñoz, Elena Buñuel
Publikováno v:
Chemistry - A European Journal. 12:1694-1702
Gold(I) complexes are the most active catalysts for the biscyclopropanation of dienynes to form tetracyclic compounds. PtII and ZnII are also able to promote the biscyclopropanation, although less efficiently. The configurations obtained in all cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cfd80982c07f32687ef3422bfa172f
https://doi.org/10.1002/chem.200501089
https://doi.org/10.1002/chem.200501089
Publikováno v:
ChemInform. 41
Reactions of 1,6-enynes catalyzed by gold(I) complexes usually proceed stereospecifically through highly distorted cyclopropyl gold carbenes. Substrates with an alkoxy substituent at the propargylic position undergo stereoselective transformations th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4c887ebed74d5c42ef0b5dbb69f1004
https://doi.org/10.1002/chin.201050245
https://doi.org/10.1002/chin.201050245
Publikováno v:
ChemInform. 41
A stereoselective gold-catalyzed [2 + 2 + 2] cycloaddition of ketoenynes substituted at the propargylic position with OR groups has been applied for the synthesis of (+)-orientalol F and pubinernoid B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66af40559bded73fe414a1f6111f4ab9
https://doi.org/10.1002/chin.201016181
https://doi.org/10.1002/chin.201016181
Autor:
Antonio M. Echavarren, Eloisa Jimenez‐Nunez, Thorsten Lauterbach, Cesar R. Solorio, Kian Molawi, Mihai Reducan
Publikováno v:
ChemInform. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd670b69925ea83dbdc1db50dfc8cef7
https://doi.org/10.1002/chin.200951040
https://doi.org/10.1002/chin.200951040