Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Eloisa Jantus‐Lewintre"'
KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination
Autor:
Rafael Rosell, Eloisa Jantus-Lewintre, Peng Cao, Xueting Cai, Baojuan Xing, Masaoki Ito, Jose Luis Gomez-Vazquez, Mireia Marco-Jordán, Silvia Calabuig-Fariñas, Andrés Felipe Cardona, Jordi Codony-Servat, Jessica Gonzalez, Kevin València-Clua, Andrés Aguilar, Carlos Pedraz-Valdunciel, Zahra Dantes, Anisha Jain, S Chandan, Miguel Angel Molina-Vila, Oscar Arrieta, Macarena Ferrero, Carlos Camps, Maria González-Cao
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background KRAS-mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS-G12C selective inhibitors, leading to short median progression-free survival, and overall survival. The ME
Externí odkaz:
https://doaj.org/article/6654162f004044148f38c519b8f50a91
Autor:
Susana Torres‐Martínez, Silvia Calabuig‐Fariñas, Andrea Moreno‐Manuel, Giulia Bertolini, Alejandro Herreros‐Pomares, Eva Escorihuela, Elena Duréndez‐Saéz, Ricardo Guijarro, Ana Blasco, Luca Roz, Carlos Camps, Eloisa Jantus‐Lewintre
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 190-215 (2024)
Despite the success of therapies in lung cancer, more studies of new biomarkers for patient selection are urgently needed. The present study aims to analyze the role of galectin‐3 (GAL‐3) in the lung tumor microenvironment (TME) using tumorsphere
Externí odkaz:
https://doaj.org/article/e94f49441c4e4aeda21fd85df71bca0e
Autor:
Irati Macaya, Marta Roman, Connor Welch, Rodrigo Entrialgo-Cadierno, Marina Salmon, Alba Santos, Iker Feliu, Joanna Kovalski, Ines Lopez, Maria Rodriguez-Remirez, Sara Palomino-Echeverria, Shane M. Lonfgren, Macarena Ferrero, Silvia Calabuig, Iziar A. Ludwig, David Lara-Astiaso, Eloisa Jantus-Lewintre, Elizabeth Guruceaga, Shruthi Narayanan, Mariano Ponz-Sarvise, Antonio Pineda-Lucena, Fernando Lecanda, Davide Ruggero, Purvesh Khatri, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Irene Ferrer, Luis Paz-Ares, Matthias Drosten, Mariano Barbacid, Ignacio Gil-Bazo, Silve Vicent
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the context of KRAS-mutat
Externí odkaz:
https://doaj.org/article/e4df0207a07b4df791d9fb4bec0b4c62
Autor:
Rafael Rosell, Anisha Jain, Jordi Codony-Servat, Eloisa Jantus-Lewintre, Blake Morrison, Jordi Barretina Ginesta, María González-Cao
Publikováno v:
Cancer Biology & Medicine, Vol 20, Iss 7, Pp 500-518 (2023)
Lung oncogenesis relies on intracellular cysteine to overcome oxidative stress. Several tumor types, including non-small cell lung cancer (NSCLC), upregulate the system xc- cystine/glutamate antiporter (xCT) through overexpression of the cystine tran
Externí odkaz:
https://doaj.org/article/c75dc006ae7f4f98914e3994f585c6bd
Autor:
Susana Torres-Martínez, Silvia Calabuig-Fariñas, Sandra Gallach, Marais Mosqueda, Ester Munera-Maravilla, Rafael Sirera, Lara Navarro, Ana Blasco, Carlos Camps, Eloisa Jantus-Lewintre
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17587 (2023)
Immunotherapy has been proven a viable treatment option for non-small cell lung cancer (NSCLC) treatment in patients. However, some patients still do not benefit. Finding new predictive biomarkers for immunocheckpoint inhibitor (ICI) response will im
Externí odkaz:
https://doaj.org/article/4dff53ea28344440a8c674c8c3cb60c4
Autor:
Atocha Romero, Eloisa Jantus‐Lewintre, Beatriz García‐Peláez, Ana Royuela, Amelia Insa, Patricia Cruz, Ana Collazo, Javier Pérez Altozano, Oscar Juan Vidal, Pilar Diz, Manuel Cobo, Berta Hernández, Sergio Vázquez Estevez, Gretel Benítez, Maria Guirado, Margarita Majem, Reyes Bernabé, Ana Laura Ortega, Ana Blasco, Joaquim Bosch‐Barrera, Jose M. Jurado, Jorge García González, Santiago Viteri, Carlos Garcia Giron, Bartomeu Massutí, Ana Lopez Martín, Alejandro Rodriguez‐Festa, Silvia Calabuig‐Fariñas, Miguel Ángel Molina‐Vila, Mariano Provencio
Publikováno v:
Molecular Oncology, Vol 15, Iss 1, Pp 43-56 (2021)
Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources for discordant results remain lacking. Herein, seven methodolo
Externí odkaz:
https://doaj.org/article/fee84be40c92476693b579001138154a
Autor:
Eloisa Jantus-Lewintre, Bartomeu Massutí Sureda, José Luis González Larriba, Delvys Rodríguez-Abreu, Oscar Juan, Ana Blasco, Manuel Dómine, Mariano Provencio Pulla, Javier Garde, Rosa Álvarez, Inmaculada Maestu, Ramón Pérez de Carrión, Ángel Artal, Christian Rolfo, Javier de Castro, Mónica Guillot, Juana Oramas, Ramón de las Peñas, Lioba Ferrera, Natividad Martínez, Òlbia Serra, Rafael Rosell, Carlos Camps
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Finding angiogenic prognostic markers in advanced non-small-cell lung cancer is still an unmet medical need. We explored a set of genetic variants in the VEGF-pathway as potential biomarkers to predict clinical outcomes of patients with non-small-cel
Externí odkaz:
https://doaj.org/article/53c890df8ad048b5aa884049551e96df
Autor:
Elena Duréndez-Sáez, Silvia Calabuig-Fariñas, Susana Torres-Martínez, Andrea Moreno-Manuel, Alejandro Herreros-Pomares, Eva Escorihuela, Marais Mosqueda, Sandra Gallach, Ricardo Guijarro, Eva Serna, Cristian Suárez-Cabrera, Jesús M. Paramio, Ana Blasco, Carlos Camps, Eloisa Jantus-Lewintre
Publikováno v:
Cancers, Vol 14, Iss 13, p 3216 (2022)
Lung cancer is a malignant disease with high mortality and poor prognosis, frequently diagnosed at advanced stages. Nowadays, immense progress in treatment has been achieved. However, the present scenario continues to be critical, and a full comprehe
Externí odkaz:
https://doaj.org/article/07bb77397eda43409b0c009da9d7069e
Autor:
Cora Palanca-Ballester, Aitor Rodriguez-Casanova, Susana Torres, Silvia Calabuig-Fariñas, Francisco Exposito, Diego Serrano, Esther Redin, Karmele Valencia, Eloisa Jantus-Lewintre, Angel Diaz-Lagares, Luis Montuenga, Juan Sandoval, Alfonso Calvo
Publikováno v:
Cancers, Vol 13, Iss 12, p 3016 (2021)
Early alterations in cancer include the deregulation of epigenetic events such as changes in DNA methylation and abnormal levels of non-coding (nc)RNAs. Although these changes can be identified in tumors, alternative sources of samples may offer adva
Externí odkaz:
https://doaj.org/article/a3346f09e04b4fcd8ef3273e6d654286
Autor:
Feiyu Zhang, Macarena Ferrero, Ning Dong, Giuseppe D’Auria, Mariana Reyes-Prieto, Alejandro Herreros-Pomares, Silvia Calabuig-Fariñas, Elena Duréndez, Francisco Aparisi, Ana Blasco, Clara García, Carlos Camps, Eloisa Jantus-Lewintre, Rafael Sirera
Publikováno v:
Cancers, Vol 13, Iss 11, p 2514 (2021)
Background: The human gut harbors around 1013–1014 microorganisms, collectively referred to as gut microbiota. Recent studies have found that the gut microbiota may have an impact on the interaction between immune regulation and anti-cancer immunot
Externí odkaz:
https://doaj.org/article/9c2c095062a6455c8c8147d16bc7eeef