ADAM17-Mediated Shedding of FcγRIIIA on Human NK Cells: Identification of the Cleavage Site and Relationship with Activation

Autor: Thierry Moreau, Hsueh Cheng Sung, Laurie Lajoie, Nicolas Congy-Jolivet, Valérie Gouilleux-Gruart, Frank Peiretti, Béatrice Clémenceau, Henri Vié, Elodie Sicard, Armelle Bolzec, Gilles Thibault

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2014, 192 (2), pp.741-751. ⟨10.4049/jimmunol.1301024⟩

FcγRIIIA/CD16A, the low-affinity receptor for the IgG Fc portion expressed on human CD56dim NK cells and involved in Ab-dependent cell cytotoxicity, is shed upon NK cell activation. We found that recombinant a disintegrin and metalloprotease (ADAM)

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https://hal.archives-ouvertes.fr/hal-02389220