Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure

Autor: Alexandre Pozza, François Giraud, Quentin Cece, Marina Casiraghi, Elodie Point, Marjorie Damian, Christel Le Bon, Karine Moncoq, Jean-Louis Banères, Ewen Lescop, Laurent J. Catoire

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Direct information on the dynamic interplay between membrane proteins and lipids is scarce. Here the authors report a detailed description of these close relationships by combining lipid nanodiscs and high-pressure NMR. They report the link between p

Externí odkaz: https://doaj.org/article/0b25f5a7a6174e4fbe1417b17d145a31

Structure of the agonist 12–HHT in its BLT2 receptor-bound state

Autor: Christel Le Bon, Jutta Rieger, Karine Moncoq, Marjorie Damian, Elodie Point, Jean-Louis Banères, Alexandre Pozza, Marina Casiraghi, Fabrice Giusti, Laurent J. Catoire

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-59571-6⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
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G Protein-Coupled receptors represent the main communicating pathway for signals from the outside to the inside of most of eukaryotic cells. They define the largest family of integral membrane receptors at the surface of the cells and constitute the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b352e278da7d581c456134ff18061d68
https://hal.archives-ouvertes.fr/hal-02482462

Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer

Autor: Elodie Point, Karine Moncoq, Marina Casiraghi, Ewen Lescop, Jean-Louis Banères, Marjorie Damian, Daniel Lévy, Eric Guittet, Nelly Morellet, Laurent Catoire, Jacky Marie

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2016, 138 (35), pp.11170-11175. ⟨10.1021/jacs.6b04432⟩

International audience; Mapping the conformational landscape of G protein-coupled receptors (GPCRs), and in particular how this landscape is modulated by the membrane environment, is required to gain a clear picture of how signaling proceeds. To this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135cb66c79fd83e7a5af074259c1b765
https://pubmed.ncbi.nlm.nih.gov/27489943

The Use of Amphipols for Solution NMR Studies of Membrane Proteins: Advantages and Constraints as Compared to Other Solubilizing Media

Autor: Jean-Luc Popot, Laurent J. Catoire, Grégory Durand, Alain Milon, Christel Le Bon, Fabrice Giusti, Tassadite Dahmane, Manuela Zoonens, Eric Guittet, Elodie Point, Marie Renault, Noelya Planchard

Publikováno v: Journal of Membrane Biology
Journal of Membrane Biology, Springer Verlag (Germany), 2014, 247 (9-10), pp.827-842. ⟨10.1007/s00232-014-9654-z⟩
Journal of Membrane Biology, Springer Verlag (Germany), 2014, 247 (9-10), pp.827-842. 〈10.1007/s00232-014-9654-z〉
Journal of Membrane Biology, Springer Verlag (Germany), 2014

International audience; Solution-state nuclear magnetic resonance studies of membrane proteins are facilitated by the increased stability that trapping with amphipols confers to most of them as compared to detergent solutions. They have yielded infor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e2f29cdfa812105c69832e8971b37e
https://hal.archives-ouvertes.fr/hal-02324097