Polypeptides derived from α-Synuclein binding partners to prevent α-Synuclein fibrils interaction with and take-up by cells.

Autor: Elodie Monsellier, Maya Bendifallah, Virginie Redeker, Ronald Melki

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237328 (2020)

α-Synuclein (αSyn) fibrils spread from one neuronal cell to another. This prion-like phenomenon is believed to contribute to the progression of the pathology in Parkinson's disease and other synucleinopathies. The binding of αSyn fibrils originati

Externí odkaz: https://doaj.org/article/6bb467d4dcc54f81a9827e642505b602

A computational approach for identifying the chemical factors involved in the glycosaminoglycans-mediated acceleration of amyloid fibril formation.

Autor: Elodie Monsellier, Matteo Ramazzotti, Niccolò Taddei, Fabrizio Chiti

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e11363 (2010)

BackgroundAmyloid fibril formation is the hallmark of many human diseases, including Alzheimer's disease, type II diabetes and amyloidosis. Amyloid fibrils deposit in the extracellular space and generally co-localize with the glycosaminoglycans (GAGs

Externí odkaz: https://doaj.org/article/3bb64fc85d6b4834a1577cb347d59b35

ProFeatMap: a highly customizable tool for 2D feature representation of protein sets

Autor: Goran Bich, Elodie Monsellier, Gilles Travé, Yves Nominé

Publikováno v: Bioinformatics Advances. 3

Motivation Studies of sets of proteins are a central point in biology. In particular, the application of omics in the last decades has generated lists of several hundreds or thousands of proteins or genes. However, these lists are often not inspected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::078b10cedcd31d80c8e32a35a99c4fa0
https://doi.org/10.1093/bioadv/vbad022

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

Autor: Maya Bendifallah, Luc Bousset, Virginie Redeker, Ronald Melki, Tracy Bellande, Elodie Monsellier

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, 2020, ⟨10.1016/j.bbrc.2020.04.091⟩
Biochemical and Biophysical Research Communications, Elsevier, 2020, ⟨10.1016/j.bbrc.2020.04.091⟩

International audience; The spread of fibrillar alpha-synuclein from affected to naïve neuronal cells is thought to contribute to the progression of synucleinopathies. The binding of fibrillar alpha-synuclein to the plasma membrane is key in this pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb96671e942687189d57238139d9ebb3
https://cea.hal.science/cea-02614589

α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane

Autor: Elodie Monsellier, Ronald Melki, Luc Bousset

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, pp.19180. ⟨10.1038/srep19180⟩

Fibrillar aggregates involved in neurodegenerative diseases have the ability to spread from one cell to another in a prion-like manner. The underlying molecular mechanisms, in particular the binding mode of the fibrils to cell membranes, are poorly u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe62c52d5dcb6de4e2ca07bb316cf92
https://doi.org/10.1038/srep19180