Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Elodie M. Da Costa"'
Autor:
Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Flores-Díaz, André Haman, Trang Hoang, Daniel Sinnett, Christian Beauséjour, Serge McGraw, Noël J.-M. Raynal
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identification of a specific c
Externí odkaz:
https://doaj.org/article/bdecc4d44be747e18ba1c9bfae4d8fcf
Autor:
Jean-Pierre J. Issa, Gabriel G. Malouf, Takahiro Sato, Hanghang Zhang, Saira Ahmed, Vazganush Gharibyan, Justin T. Lee, Elodie M. Da Costa, Noël J.-M. Raynal
Supplementary Fig. S1: Percentage of drugs per drug class among drug libraries used in the HTS; Supplementary Fig. S2: Synergistic GFP reactivation in YB5 cells by HDACi TSA and positive hits identified in the HTS; Supplementary Fig. S3: Optimization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dce1c4970e7eb45f23d3d77f0b11dc9
https://doi.org/10.1158/1535-7163.22503463.v1
https://doi.org/10.1158/1535-7163.22503463.v1
Publikováno v:
The Cancer Journal. 23:270-276
Targeting DNA hypermethylation, using nucleoside analogs, is an efficient approach to reprogram cancer cell epigenome leading to reduced proliferation, increased differentiation, recognition by the immune system, and ultimately cancer cell death. DNA
Autor:
André Haman, Noël J.-M. Raynal, Annie Beaudry, Moutih Rafei, Kolja Eppert, Yuka Sai, Serge McGraw, Elodie M. Da Costa, Jeffrey R. Johnson, Nevan J. Krogan, Trang Hoang, Chantal Richer, Daniel Sinnett, Meaghan Boileau, Ema Flores-Diaz, Pascal St-Onge, Christian Beauséjour, Maxime Caron, Gregory Armaos, Virginie Bertrand-Lehouillier, Gabrielle McInnes, Michael Downey, Gaël Moquin-Beaudry
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Background Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identification of a specific cancer typ
Autor:
Gaël Moquin-Beaudry, Moutih Rafei, Trang Hoang, Jeffrey S. Johnson, Virginie Bertrand-Lehouillier, Gabrielle McInnes, Annie Beaudry, Nevan J. Krogan, Daniel Sinnett, André Haman, Elodie M. Da Costa, Yuka Sai, Pascal St-Onge, Michael Downey, Christian Beauséjour, Maxime Caron, Chantal Richer, Serge McGraw, Meaghan Boileau, Kolja Eppert, Gregory Armaos, Ema Flores-Diaz, Noël J.-M. Raynal
Targeting MYC oncogene remains a major therapeutic goal in cancer chemotherapy. Here, we demonstrate that proscillaridin, a cardiac glycoside approved for heart failure treatment exhibit anticancer selectivity towards high MYC expressing leukemic cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5263bbd3194d6fefb505d5786f889ad2
https://doi.org/10.1101/444133
https://doi.org/10.1101/444133
Autor:
Justin T. Lee, Hanghang Zhang, Gabriel G. Malouf, Elodie M. Da Costa, Takahiro Sato, Jean Pierre J. Issa, Saira Ahmed, Noël J.-M. Raynal, Vazganush Gharibyan
Publikováno v:
Molecular cancer therapeutics. 16(2)
Epigenetic drugs, such as DNA methylation inhibitors (DNMTi) or histone deacetylase inhibitors (HDACi), are approved in monotherapy for cancer treatment. These drugs reprogram gene expression profiles, reactivate tumor suppressor genes (TSG) producin
Autor:
Yuka Sai, Annie Beaudry, Gregory Armaos, Daniel Sinnett, Maxime Caron, Chantal Richer, Pascal St-Onge, Noël J.-M. Raynal, Serge McGraw, Michael Downey, Nevan J. Krogan, Jeffrey R. Johnson, Elodie M. Da Costa
Publikováno v:
Cancer Research. 78:1381-1381
In cancer, epigenetic modifications are strongly altered and are responsible for gene expression aberrations. In a drug screening initiative, we recently reported that proscillaridin, a cardiac glycoside (CG), exhibits unsuspected epigenetic and anti
Autor:
Elodie M. Da Costa, Noël J.-M. Raynal, Maxime Caron, Gregory Armaos, Pascal St-Onge, Daniel Sinnett, Simon Jacques-Ricard, Serge McGraw, Annie Beaudry
Publikováno v:
Cancer Research. 77:1375-1375
Epigenetic modifications play a key role in establishing and maintaining gene expression. In cancer, they are highly altered and responsable of gene expression deregulation. Epigenetic drugs have the ability to reset cancer cell epigenome producing c
Publikováno v:
Cancer Research. 76:4526-4526
Acute lymphoblastic leukemia (ALL) represents approximately 25% of all pediatric cancers diagnosed every year. In about 80% of cases, pediatric patients will attain an event-free 5-year survival. Unfortunately, patients who are resistant to treatment
Publikováno v:
Cancer Research. 76:3200-3200
Pediatric neuroblastoma is one of the most common extra cranial cancers in children. Despite an improvement in survival with the currently available therapies, neuroblastoma with an amplification of the transcription factor MYCN have a very poor prog