Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Elodie L. Plan"'
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2310-2322 (2023)
Abstract The Mayo Clinical Score is used in clinical trials to describe the clinical status of patients with ulcerative colitis (UC). It comprises four subscores: rectal bleeding (RB), stool frequency (SF), physician's global assessment, and endoscop
Externí odkaz:
https://doaj.org/article/107fa89c02734a2698e4c04b30c5afe5
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 6, Pp 758-769 (2023)
Abstract BI 730357 is investigated as an oral treatment of plaque psoriasis. We analyzed the impact of three dosage regimens on the Psoriasis Area and Severity Index (PASI) response with modeling based on phase I and II data from 109 healthy subjects
Externí odkaz:
https://doaj.org/article/9f3709a3d792455c8294af56375c3e83
Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item‐score models
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 4, Pp 309-317 (2021)
Abstract This study tested the hypothesis that analyzing longitudinal item scores of the Unified Parkinson's Disease Rating Scale could allow a smaller trial size and describe a drug's effect on symptom progression. Two historical studies of the dopa
Externí odkaz:
https://doaj.org/article/cd36e42c22234c9dbb504eb4314a8ef1
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology.
Joint longitudinal model-based meta-analysis of FEV1 and exacerbation rate in randomized COPD trials
Autor:
Carolina Llanos-Paez, Claire Ambery, Shuying Yang, Misba Beerahee, Elodie L. Plan, Mats O. Karlsson
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics.
Model-based meta-analysis (MBMA) is an approach that integrates relevant summary level data from heterogeneously designed randomized controlled trials (RCTs). This study not only evaluated the predictability of a published MBMA for forced expiratory
Autor:
Carolina Llanos-Paez, Claire Ambery, Shuying Yang, Misba Beerahee, Elodie L. Plan, Mats O. Karlsson
Publikováno v:
Pharmaceutical Research. 39:1779-1787
Purpose The current study aimed to illustrate how a non-linear mixed effect (NLME) model-based analysis may improve confidence in a Phase III trial through more precise estimates of the drug effect. Methods The FULFIL clinical trial was a Phase III s
Autor:
Shuying Yang, Carolina Llanos-Paez, Elodie L. Plan, Claire Ambery, Maggie Tabberer, Mats O. Karlsson, Misba Beerahee
Publikováno v:
The AAPS Journal
This study aimed to illustrate how a new methodology to assess clinical trial outcome measures using a longitudinal item response theory–based model (IRM) could serve as an alternative to mixed model repeated measures (MMRM). Data from the EXACT (E
Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item-score models
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 4, Pp 309-317 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
This study tested the hypothesis that analyzing longitudinal item scores of the Unified Parkinson's Disease Rating Scale could allow a smaller trial size and describe a drug's effect on symptom progression. Two historical studies of the dopaminergic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e321c9a5401d40648d679245272c837b
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-444919
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-444919
Autor:
Gopichand Gottipati, Shuying Yang, Mats O. Karlsson, Chao Chen, Elodie L. Plan, Alienor Berges
Publikováno v:
Pharmaceutical Research
Purpose The aim of this work was to allow combination of information from recent and historical trials in Parkinson’s Disease (PD) by developing bridging methodology between two versions of the clinical endpoint. Methods A previously developed Item
Publikováno v:
The AAPS Journal
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with approximately 174 million cases worldwide. Electronic questionnaires are increasingly used for collecting patient-reported-outcome (PRO) data about disease symptoms. Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fa7ea1748c2e02bd85ce0a865f1fc3
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-383495
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-383495