Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites.

Autor: Elodie Gazanion, Laurent Lacroix, Patrizia Alberti, Pratima Gurung, Sharon Wein, Mingpan Cheng, Jean-Louis Mergny, Ana Rita Gomes, Jose-Juan Lopez-Rubio

Publikováno v: PLoS Genetics, Vol 16, Iss 7, p e1008917 (2020)

Mechanisms of transcriptional control in malaria parasites are still not fully understood. The positioning patterns of G-quadruplex (G4) DNA motifs in the parasite's AT-rich genome, especially within the var gene family which encodes virulence factor

Externí odkaz: https://doaj.org/article/ed2703436f1b408ea372dc26315b21b6

Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites

Autor: Jean-Louis Mergny, Laurent Lacroix, Patrizia Alberti, Jose-Juan Lopez-Rubio, Ana Rita Gomes, Pratima Gurung, Elodie Gazanion, Mingpan Cheng, Sharon Wein

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2020, 16 (7), pp.e1008917. ⟨10.1371/journal.pgen.1008917⟩
PLoS Genetics, 2020, 16 (7), pp.e1008917. ⟨10.1371/journal.pgen.1008917⟩
PLoS Genetics, Vol 16, Iss 7, p e1008917 (2020)

Mechanisms of transcriptional control in malaria parasites are still not fully understood. The positioning patterns of G-quadruplex (G4) DNA motifs in the parasite’s AT-rich genome, especially within the var gene family which encodes virulence fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e793c625a2e9c253e09b61361deb25
https://hal.umontpellier.fr/hal-03152243

Cos-Seq: A High-Throughput Gain-of-Function Screen for Drug Resistance Studies in Leishmania

Autor: Jade-Eva, Potvin, Philippe, Leprohon, Elodie, Gazanion, Mansi, Sharma, Christopher, Fernandez-Prada, Marc, Ouellette

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1971

Leishmania is still a major cause of mortality and morbidity worldwide. Few efficient drugs are available, and resistance threatens actual treatments. In order to improve knowledge about the mode of action of current drugs and those in development, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe33f027de3ee661ade2bc930c284e20
https://pubmed.ncbi.nlm.nih.gov/30980302

A single amino acid substitution (H451Y) in Leishmania calcium-dependent kinase SCAMK confers high tolerance and resistance to antimony

Autor: Baptiste Vergnes, Yvon Sterkers, Lauriane Sollelis, Cédric Mariac, Anne-Laure Bañuls, Miléna Du Manoir, Jose-Juan Lopez-Rubio, Elodie Gazanion

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2019, 74 (11), pp.3231-3239. ⟨10.1093/jac/dkz334⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2019, 74 (11), pp.3231-3239. ⟨10.1093/jac/dkz334⟩

Background For almost a century, antimonials have remained the first-line drugs for the treatment of leishmaniasis. However, little is known about their mode of action and clinical resistance mechanisms. Objectives We have previously shown that Leish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ddc65098656969936fd63993367525
https://hal.umontpellier.fr/hal-02494096/file/Sterkers_30.pdf

Protozoan Parasite Auxotrophies and Metabolic Dependencies

Autor: Elodie Gazanion, Baptiste Vergnes

Publikováno v: Experientia Supplementum
Experientia Supplementum, pp.351-375, 2018, ⟨10.1007/978-3-319-74932-7_9⟩
Experientia Supplementum ISBN: 9783319749310

Diseases caused by protozoan parasites have a major impact on world health. These early branching eukaryotes cause significant morbidity and mortality in humans and livestock. During evolution, protozoan parasites have evolved toward complex life cyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c529ab37f872a9103fee758121901e
https://hal.umontpellier.fr/hal-02872225