Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Elodie Couplan"'
1
The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity
Autor: Elodie Couplan, Kentaro Ohkuni, Sangkyu Kim, S. Michal Jazwinski
Publikováno v: Biogerontology. 5:305-316
Transcriptional silencing decreases at both subtelomeric and silent mating-type loci and increases at the ribosomal DNA locus during the replicative life span of the yeast Saccharomyces cerevisiae . Evidence exists that epigenetic changes in the regu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b7b1e4c0b43262bc3eff06fdd7acb1
https://doi.org/10.1007/s10522-004-2568-x
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2
Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders
Autor: Charlotta Funaya, Marc Blondel, Raeka S. Aiyar, Lars M. Steinmetz, Elodie Couplan, Claude Antony, Florence Courtin, Emilie S. Fritsch, Roza Kucharczyk, Karina von der Malsburg, Martin van der Laan, Justine Evrard, Sundari Suresh, Robert P. St.Onge, Flavie Soubigou, Jean-Paul di Rago, Cécile Voisset, Stéphane Duvezin-Caubet, Maria Bohnert, Julien Gagneur
Publikováno v: Nature Communications
Mitochondrial diseases are systemic, prevalent and often fatal; yet treatments remain scarce. Identifying molecular intervention points that can be therapeutically targeted remains a major challenge, which we confronted via a screening assay we devel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97519c6c30a8f45875a0b6e35473b9e9
https://doi.org/10.1038/ncomms6585
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4
A yeast-based assay identifies drugs active against human mitochondrial disorders
Autor: Jean-Paul di Rago, Lars M. Steinmetz, Raeka S. Aiyar, Marie Le Cann, Nahia Ezkurdia, Roza Kucharczyk, Flavie Soubigou, Robert P. St.Onge, Marc Blondel, Bénédicte Salin, Julien Gagneur, Anna Magdalena Kabala, Elodie Couplan
Due to the lack of relevant animal models, development of effective treatments for human mitochondrial diseases has been limited. Here we establish a rapid, yeast-based assay to screen for drugs active against human inherited mitochondrial diseases a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3039f9a24c46fa1bddf43ffcbad7a9
https://hal.archives-ouvertes.fr/hal-00608540
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5
Polyunsaturated fatty acids inhibit PI3K activity in a yeast-based model system
Autor: Christelle Le Foll, Elodie Couplan, Marie Le Cann, Charlotte Corporeau, J. Delarue, Marc Blondel
Publikováno v: Biotechnology Journal
Biotechnology Journal, Wiley-VCH Verlag, 2009, 4 (8), pp.1190-n/a. ⟨10.1002/biot.200800229⟩
The phosphatidylinositol 3-kinase (PI3K) pathway controls the regulation of cell growth, proliferation, migration and apoptosis. In many tumors, the PI3K gene is mutated or overexpressed, and/or the PI3K pathway is hyperactive. PI3K is therefore a po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667fb5571efe8f47c79e76a385b1d533
https://hal.archives-ouvertes.fr/hal-00495059/file/PEER_stage2_10.1002%2Fbiot.200800229.pdf
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6
Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide
Autor: Bernard Mignotte, Marc Goubern, Frédéric Bouillaud, Catherine Chaumontet, Caroline Petit, Hervé M. Blottière, Anthony Pagniez, Maria-del-Mar Gonzalez-Barroso, Mireille Andriamihaja, Elodie Couplan, Xavier Leschelle, François Blachier
Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2005, 1725, pp.201-212. ⟨10.1016/j.bbagen.2005.06.002⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2005, 1725, pp.201-212
HAL
International audience; Hydrogen sulfide (H2S), a bacterial metabolite present in the lumen of the large intestine, is able to exert deleterious effects on the colonic epithelium. The mechanisms involved are still poorly understood, the reported effe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2e7d6da304c3090a2d669068f144b2
https://hal.inrae.fr/hal-02679265
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7
Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage
Autor: Frédéric Bouillaud, C. Gelly, Maria-del-Mar Gonzalez-Barroso, Philippe Mateo, Anne-Marie Cassard-Doulcier, Philippe Diolez, J. A. Hoerter, Elodie Couplan
Publikováno v: Circulation. 110(5)
Background— Mitochondrial respiration is the main source of energy in aerobic animal cells and is adapted to the energy demand by respiratory coupling. Uncoupling proteins (UCPs) perturb respiratory coupling by inducing a proton leak through the mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c512a9f301f2714fbc4648ab78ea4a42
https://pubmed.ncbi.nlm.nih.gov/15262832
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9
No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria
Autor: Maria del Mar Gonzalez-Barroso, Frédéric Bouillaud, Marie-Clotilde Alves-Guerra, Daniel Ricquier, Marc Goubern, Elodie Couplan
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2002, 277 (29), pp.26268-26275. ⟨10.1074/jbc.M202535200⟩
The phenotypes observed in mice whose uncoupling protein (Ucp2) gene had been invalidated by homologous recombination (Ucp2(-/-) mice) are consistent with an increase in mitochondrial membrane potential in macrophages and pancreatic beta cells. This
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c11b4e40fd84af14ef46528c5f7815
https://hal.archives-ouvertes.fr/hal-03054567
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