Incorporation of apolipoprotein E into HBV–HCV subviral envelope particles to improve the hepatitis vaccine strategy

Autor: Elsa Gomez-Escobar, Julien Burlaud-Gaillard, Clara Visdeloup, Adeline Ribeiro E. Silva, Pauline Coutant, Philippe Roingeard, Elodie Beaumont

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Hepatitis C is a major threat to public health for which an effective treatment is available, but a prophylactic vaccine is still needed to control this disease. We designed a vaccine based on chimeric HBV–HCV envelope proteins forming sub

Externí odkaz: https://doaj.org/article/ee22fd30af2043aa8d96fa2f0f897d87

IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense

Autor: Vincent Larochette, Charline Miot, Caroline Poli, Elodie Beaumont, Philippe Roingeard, Helmut Fickenscher, Pascale Jeannin, Yves Delneste

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily, and is a novel mediator of inflammation overexpressed in activated or transformed T cells. Novel properties have recently been assigned to IL-26, owing to

Externí odkaz: https://doaj.org/article/7e79cbd4c02d46ff8a5bdde438edc972

Mixing particles from various HCV genotypes increases the HBV‐HCV vaccine ability to elicit broadly cross‐neutralizing antibodies

Autor: Emmanuelle Roch, Lucie Chopin, Vanessa Guérin, Elodie Beaumont, Benoit Joël Clément, Philippe Roingeard, Elsa Gomez-Escobar

Publikováno v: Liver International. 40:1865-1871

The development of a safe, effective and affordable prophylactic vaccine against hepatitis C virus (HCV) remains a medical priority. Hepatitis B-C subviral envelope particles, which could be produced by industrial procedures adapted from those establ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a756ace1863acbc7d195bd0ad674980
https://doi.org/10.1111/liv.14541

Prospects for prophylactic hepatitis C vaccines based on virus-like particles

Autor: Philippe Roingeard, Elodie Beaumont

Publikováno v: Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics, Taylor & Francis, 2013, 9 (5), pp.1112-8. ⟨10.4161/hv.23900⟩

International audience; Given the global prevalence and long-term complications of chronic hepatitis C virus (HCV) infection, HCV constitutes one of the greatest challenges to human health of this decade. Considerable efforts have focused on the deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b90e7d38346f29a12c89d0d2c080863
https://doi.org/10.4161/hv.23900

Hepatitis C Virus E1 and E2 Proteins Used as Separate Immunogens Induce Neutralizing Antibodies with Additive Properties

Autor: Lucie Chopin, Elodie Beaumont, Emmanuelle Roch, Philippe Roingeard

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (3), pp.e0151626 (eCollection 2016). ⟨10.1371/journal.pone.0151626.s003⟩
PLoS ONE, Vol 11, Iss 3, p e0151626 (2016)

International audience; Various strategies involving the use of hepatitis C virus (HCV) E1 and E2 envelope glyco-proteins as immunogens have been developed for prophylactic vaccination against HCV. However, the ideal mode of processing and presenting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031cf318362b582aa6eede59dcb7c84d
https://www.hal.inserm.fr/inserm-01575074