Design of multi-epitope peptides containing HLA class-I and class-II-restricted epitopes derived from immunogenic Leishmania proteins, and evaluation of CD4+ and CD8+ T cell responses induced in cured cutaneous leishmaniasis subjects.

Autor: Sarra Hamrouni, Rachel Bras-Gonçalves, Abdelhamid Kidar, Karim Aoun, Rym Chamakh-Ayari, Elodie Petitdidier, Yasmine Messaoudi, Julie Pagniez, Jean-Loup Lemesre, Amel Meddeb-Garnaoui

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008093 (2020)

Human leishmaniasis is a public health problem worldwide for which the development of a vaccine remains a challenge. T cell-mediated immune responses are crucial for protection. Peptide vaccines based on the identification of immunodominant T cell ep

Externí odkaz: https://doaj.org/article/c109f096903c431e9559b673198335d1

A transition support system to build decarbonization scenarios in the academic community

Autor: Nicolas Gratiot, Jérémie Klein, Marceau Challet, Olivier Dangles, Serge Janicot, Miriam Candelas, Géraldine Sarret, Géremy Panthou, Benoît Hingray, Nicolas Champollion, Julien Montillaud, Pascal Bellemain, Odin Marc, Cédric-Stéphane Bationo, Loïs Monnier, Laure Laffont, Marie-Alice Foujols, Véronique Riffault, Liselotte Tinel, Emmanuel Mignot, Nathalie Philippon, Alain Dezetter, Alexandre Caron, Guillaume Piton, Aurélie Verney-Carron, Anne Delaballe, Nelly Bardet, Florence Nozay-Maurice, Anne-Sophie Loison, Franck Delbart, Sandrine Anquetin, Françoise Immel, Christophe Baehr, Fabien Malbet, Céline Berni, Laurence Delattre, Vincent Echevin, Elodie Petitdidier, Olivier Aumont, Florence Michau, Nicolas Bijon, Jean-Philippe Vidal, Sébastien Pinel, Océane Biabiany, Cathy Grevesse, Louise Mimeau, Anne Biarnès, Charlotte Récapet, Morgane Costes-Thiré, Mariline Poupaud, Maialen Barret, Marie Bonnin, Virginie Mournetas, Bernard Tourancheau, Bertrand Goldman, Marie Paule Bonnet, Isabelle Michaud Soret

Publikováno v: PLOS Sustainability and Transformation
PLOS Sustainability and Transformation, 2023, 2 (4), pp.e0000049. ⟨10.1371/journal.pstr.0000049⟩
PLoS Sustainability and Transformation

A growing portion of scientists realises the need to not only alert about climate change, but also change their professional practices. A range of tools have emerged to promote more sustainable activities, yet many scientists struggle to go beyond si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ece46347f45e767cb1ea9b38f935ee
https://doi.org/10.1371/journal.pstr.0000049

Proteomic analysis of the promastigote secretome of seven Leishmania species

Autor: Joana Pissarra, Philippe Holzmuller, Julie Pagniez, Oana Vigy, Rachel Bras-Gonçalves, Jean-Loup Lemesre, Martial Séveno, Elodie Petitdidier

Publikováno v: Journal of Proteome Research
Journal of Proteome Research, American Chemical Society, 2022, 21 (1), pp.30-48. ⟨10.1021/acs.jproteome.1c00244⟩
Journal of Proteome Research, American Chemical Society, 2021, ⟨10.1021/acs.jproteome.1c00244⟩

International audience; Leishmaniasis is one of the most impactful parasitic diseases worldwide, endangering the lives of 1 billion people every year. There are 20 different species of Leishmania able to infect humans, causing cutaneous (CL), viscera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e867a68a8788a39e54eb7df0c8fba094
http://agritrop.cirad.fr/601843/

Unravelling human trypanotolerance: IL8 is associated with infection control whereas IL10 and TNFα are associated with subsequent disease development.

Autor: Hamidou Ilboudo, Rachel Bras-Gonçalves, Mamadou Camara, Laurence Flori, Oumou Camara, Hassane Sakande, Mamadou Leno, Elodie Petitdidier, Vincent Jamonneau, Bruno Bucheton

Publikováno v: PLoS Pathogens, Vol 10, Iss 11, p e1004469 (2014)

In West Africa, Trypanosoma brucei gambiense, causing human African trypanosomiasis (HAT), is associated with a great diversity of infection outcomes. In addition to patients who can be diagnosed in the early hemolymphatic phase (stage 1) or meningoe

Externí odkaz: https://doaj.org/article/897540bc64af436fb0654d60f5ea92e0

Optimized transitory ectopic expression of promastigote surface antigen protein in Nicotiana benthamiana, a potential anti-leishmaniasis vaccine candidate

Autor: Christophe Brugidou, Jean-Paul Brizard, Séverine Lacombe, Drissa Sérémé, Jean-Loup Lemesre, Martine Bangratz, Elodie Petitdidier, Julie Pagniez

Publikováno v: Journal of Bioscience and Bioengineering. 125:116-123

In recent years, plants have been shown to be an efficient alternative expression system for high-value pharmaceuticals such as vaccines. However, constitutive expression of recombinant protein remains uncertain on their level of production and biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca49a9d7cf5f1702e50520235b40fd9e
https://doi.org/10.1016/j.jbiosc.2017.07.008