Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

Autor: Elo Madissoon, Virpi Töhönen, Liselotte Vesterlund, Shintaro Katayama, Per Unneberg, Jose Inzunza, Outi Hovatta, Juha Kere

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e102949 (2014)

Infertility is a worldwide concern that can be treated with in vitro fertilization (IVF). Improvements in IVF and infertility treatment depend largely on better understanding of the molecular mechanisms for human preimplantation development. Several

Externí odkaz: https://doaj.org/article/9a6193b6f1564e468da9439ed1e5a360

An integrated cell atlas of the human lung in health and disease

Autor: Malte Luecken, Lisa Sikkema, Daniel Strobl, Luke Zappia, Elo Madissoon, Nikolay Markov, Laure-Emmanuelle Zaragosi, Meshal Ansari, Marie-Jeanne Arguel, Leonie Apperloo, Christophe Becavin, Marijn Berg, Evgeny Chichelnitskiy, Mei-i Chung, Antoine Collin, Aurore Gay, Baharak Hooshiar Kashani, Manu Jain, Theodore Kapellos, Tessa Kole, Christoph Mayr, Michael von Papen, Lance Peter, Ciro Ramírez-Suástegui, Janine Schniering, Chase Taylor, Thomas Walzthoeni, Chuan Xu, Linh Bui, Carlo de Donno, Leander Dony, Minzhe Guo, Austin Gutierrez, Lukas Heumos, Ni Huang, Ignacio Ibarra Del Río, Nathan Jackson, Preetish Kadur Lakshminarasimha Murthy, Mohammad Lotfollahi, Tracy Tabib, Carlos Talavera-Lopez, Kyle Travaglini, Anna Wilbrey-Clark, Kaylee Worlock, Masahiro Yoshida, Tushar Desai, Orit Rozenblatt-Rosen, Christine Falk, Naftali Kaminski, Mark Krasnow, Robert Lafyatis, Marko Nikolic, Joseph Powell, Jay Rajagopal, Max Seibold, Dean Sheppard, Douglas Shepherd, Sarah Teichmann, Alexander Tsankov, Jeffrey Whitsett, Yan Xu, Nicholas Banovich, Pascal Barbry, Thu Duong, Kerstin Meyer, Jonathan Kropski, Dana Pe'er, Herbert Schiller, Purushothama Rao Tata, Joachim Schultze, Maarten van den Berge, Yuexin Chen, James Hagood, Ahmed Hassan, Peter Horvath, Joakim Lundeberg, Sylvie Leroy, Charles Marquette, Gloria Pryhuber, Christos Samakovlis, Xin Sun, Lorraine Ware, Kun Zhang, Alexander Misharin, Martijn Nawijn, Fabian Theis

Organ- and body-scale cell atlases have the potential to transform our understanding of human biology. To capture the variability present in the population, these atlases must include diverse demographics such as age and ethnicity from both healthy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c225b8ec842494e3c796c31c793715c
https://doi.org/10.21203/rs.3.rs-1438584/v1

The discovAIR project

Autor: Malte D. Luecken, Laure-Emmanuelle Zaragosi, Elo Madissoon, Lisa Sikkema, Alexandra B. Firsova, Elena De Domenico, Louis Kümmerle, Adem Saglam, Marijn Berg, Aurore C.A. Gay, Janine Schniering, Christoph H. Mayr, Xesús M. Abalo, Ludvig Larsson, Alexandros Sountoulidis, Sarah A. Teichmann, Karen van Eunen, Gerard H. Koppelman, Kourosh Saeb-Parsy, Sylvie Leroy, Pippa Powell, Ugis Sarkans, Wim Timens, Joakim Lundeberg, Maarten van den Berge, Mats Nilsson, Peter Horváth, Jessica Denning, Irene Papatheodorou, Joachim L. Schultze, Herbert B. Schiller, Pascal Barbry, Ilya Petoukhov, Alexander V. Misharin, Ian M. Adcock, Michael von Papen, Fabian J. Theis, Christos Samakovlis, Kerstin B. Meyer, Martijn C. Nawijn

Publikováno v: European Respiratory Journal
The European respiratory journal 60(2), 2102057 (2022). doi:10.1183/13993003.02057-2021
Eur. Respir. J. 59:2102057 (2022)

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f581433ea51435d26d857eb0a83d27a3
https://hdl.handle.net/11370/eeca5057-97a6-45f7-9dac-92e84b6d1f46

A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates

Autor: Peng He, Kyungtae Lim, Dawei Sun, Jan Patrick Pett, Quitz Jeng, Krzysztof Polanski, Ziqi Dong, Liam Bolt, Laura Richardson, Lira Mamanova, Monika Dabrowska, Anna Wilbrey-Clark, Elo Madissoon, Zewen Kelvin Tuong, Emma Dann, Chenqu Suo, Isaac Goh, Masahiro Yoshida, Marko Z Nikolić, Sam M Janes, Xiaoling He, Roger A Barker, Sarah A Teichmann, John C. Marioni, Kerstin B Meyer, Emma L Rawlins

Publikováno v: Cell. 185:4841-4860.e25

We present a multiomic cell atlas of human lung development that combines single cell RNA and ATAC sequencing, high throughput spatial transcriptomics and single cell imaging. Coupling single cell methods with spatial analysis has allowed a comprehen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2004b9795fc41ebe14d787333c315da4
https://doi.org/10.1016/j.cell.2022.11.005

T1 The local and systemic response to SARS-CoV-2 infection in children and adults

Autor: Rgh Lindeboom, BC Jones, Muzlifah Haniffa, Laura Richardson, C Dominguez Conde, JP Pett, Sean B. Smith, Elo Madissoon, V Chu, Ca Gao, Aarash Saleh, Sarah Teichmann, Krzysztof Polanski, Eliz Kilich, A-K Reuschl, Jessica Allen-Hyttinen, Neil J. Sebire, Kerstin B. Meyer, H Yung, Alexander V. Misharin, A Saigal, Clatworthy, Clare Jolly, Jane Dematte, Waradon Sungnak, C Cane, Marko Nikolic, Colin R. Butler, Ni Huang, Puja Mehta, Claire Smith, Elena Prigmore, Natsuhiko Kumasaka, Fernando J Calero-Nieto, Taylor A. Poor, Josephine Barnes, S Shibuya, NU Script Study Investigators, Kaylee B Worlock, AC Argento, Anna Wilbrey-Clark, A Iordanidou, Sam M. Janes, P De Coppi, Matthew L Coates, Jonathan M. Cohen, Liam Bolt, Lira Mamanova, Masahiro Yoshida, Berthold Göttgens, Gary Reynolds, Richard G. Wunderink, Christopher O'Callaghan, Georgina Bowyer, A de Wilton

Publikováno v: BTS/BALR/AUK-BLF Early Career Investigator Symposium.

T1 Figure 1ConclusionsOverall, this largest paediatric single cell COVID-19 study to date showed significant differences in response to SARS-CoV-2 between children and adults, reflecting the changes of the immune landscape over developmental time, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aad24e6918d8a981a5285a5a1044e38
https://doi.org/10.1136/thorax-2021-btsabstracts.1