Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elnaz Mirzaei Mehrabad"'
Autor:
Ozlen Balcioglu, Brooke L. Gates, David W. Freeman, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, David Ayala-Talavera, Benjamin T. Spike
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Cell state control is crucial for normal tissue development and cancer cell mimicry of stem/progenitor states, contributing to tumor heterogeneity, therapy resistance, and progression. Here, we demonstrate that the cell surface glycoprotein
Externí odkaz:
https://doaj.org/article/d5c5ca99a1c0441b847786a473f5db05
Autor:
Manish Ranjan, Oukseub Lee, Gannon Cottone, Elnaz Mirzaei Mehrabad, Benjamin T. Spike, Zexian Zeng, Shivangi Yadav, Robert Chatterton, J. Julie Kim, Susan E. Clare, Seema A. Khan
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-17 (2021)
Abstract Background The ovarian hormones estrogen and progesterone (EP) are implicated in breast cancer causation. A specific consequence of progesterone exposure is the expansion of the mammary stem cell (MSC) and luminal progenitor (LP) compartment
Externí odkaz:
https://doaj.org/article/54ebd66fced14276b1e7e69565c3d521
Autor:
Ozlen Balcioglu, Richard E. Heinz, David W. Freeman, Brooke L. Gates, Berhane M. Hagos, Evan Booker, Elnaz Mirzaei Mehrabad, Hyrum T. Diesen, Kishan Bhakta, Supraja Ranganathan, Masami Kachi, Mathias Leblanc, Peter C. Gray, Benjamin T. Spike
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-14 (2020)
Abstract Background CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia
Externí odkaz:
https://doaj.org/article/c3087deb5d704acbbb79917f2e2e47ce
Autor:
Rediet Zewdu, Elnaz Mirzaei Mehrabad, Kelley Ingram, Pengshu Fang, Katherine L Gillis, Soledad A Camolotto, Grace Orstad, Alex Jones, Michelle C Mendoza, Benjamin T Spike, Eric L Snyder
Publikováno v:
eLife, Vol 10 (2021)
Cancer cells undergo lineage switching during natural progression and in response to therapy. NKX2-1 loss in human and murine lung adenocarcinoma leads to invasive mucinous adenocarcinoma (IMA), a lung cancer subtype that exhibits gastric differentia
Externí odkaz:
https://doaj.org/article/6480f1d0e1a849568a7cc19f30a0c0d1
Autor:
Rajshekhar R. Giraddi, Chi-Yeh Chung, Richard E. Heinz, Ozlen Balcioglu, Mark Novotny, Christy L. Trejo, Christopher Dravis, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, Luo Wei Rodewald, Jae Y. Hwang, Cheng Fan, Roger Lasken, Katherine E. Varley, Charles M. Perou, Geoffrey M. Wahl, Benjamin T. Spike
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
Summary: The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We ad
Externí odkaz:
https://doaj.org/article/38eeb434d83440d7b7cd474042626a72
Autor:
Ozlen Balcioglu, Brooke L. Gates, David W. Freeman, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, David Ayala-Talavera, Benjamin T. Spike
Breast cancers are categorized into subtypes with distinctive therapeutic vulnerabilities based on expression of clinically targetable receptors and other genes that mimic cell types of the normal gland. Here, we tested the role of the plasma membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faa4b6a05b256ba2d587114b29ebfe43
https://doi.org/10.1101/2023.05.10.540211
https://doi.org/10.1101/2023.05.10.540211
Publikováno v:
Cancer Research. 82:P3-09
Background: As bulk and single-cell RNA (scRNA) sequencing studies and data continue to accrue to publicly accessible databases, bioinformatic tools continue being developed to analyze these datasets. The resulting pipelines often focus on either bul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb7340b8b05203a21d04ba646d5215fd
https://doi.org/10.1158/1538-7445.sabcs21-p3-09-16
https://doi.org/10.1158/1538-7445.sabcs21-p3-09-16
Autor:
Xiaomeng Hou, J Hwang, Charles M. Perou, Bing Ren, Tannishtha Reya, Christy L. Trejo, Zhibo Ma, Christopher Dravis, Sebastian Preissl, Jaslem Herrera-Valdez, Benjamin T. Spike, Roger S. Lasken, Mark Novotny, Geoff Wahl, Elnaz Mirzaei Mehrabad, Berhane M. Hagos, NE Lytle, Ozlen Balcioglu, Olivier Poirion, KT Varley, Chi-Yeh Chung, Cheng Fan, Gidsela Luna, RT Giraddi, Richard E. Heinz
Publikováno v:
Cancer Research. 80:ES10-2
Parallels among embryonic development, stem cells, and cancer have long been recognized. We identified, isolated, and characterized stem cells that first become committed to a mammary fate during embryogenesis; we refer to these cells as fetal mammar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eea19019b08580e51d8685a3f9dde727
https://doi.org/10.1158/1538-7445.sabcs19-es10-2
https://doi.org/10.1158/1538-7445.sabcs19-es10-2
Autor:
Alex Jones, Eric L. Snyder, Elnaz Mirzaei Mehrabad, Rediet Zewdu, Kelley Ingram, Pengshu Fang, Soledad A. Camolotto, Benjamin T Spike, Grace Orstad, Katherine L Gillis, Michelle C. Mendoza
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Cancer cells undergo lineage switching during natural progression and in response to therapy. NKX2-1 loss in human and murine lung adenocarcinoma leads to invasive mucinous adenocarcinoma (IMA), a lung cancer subtype that exhibits gastric differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdbb66b9b655fd04abc0db23a03d5cb7
https://elifesciences.org/articles/66788
https://elifesciences.org/articles/66788
Autor:
Rediet Zewdu, Pengshu Fang, Alex Jones, Soledad A. Camolotto, Elnaz Mirzaei Mehrabad, Eric L. Snyder, Michelle C. Mendoza, Katherine L Gillis, Benjamin T Spike, Kelley Ingram, Grace Orstad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f25c9a81294e5dc6de61feae747b645a
https://doi.org/10.7554/elife.66788.sa2
https://doi.org/10.7554/elife.66788.sa2