Automated cell tracking using StarDist and TrackMate [version 2; peer review: 3 approved]

Autor: Elnaz Fazeli, Nathan H. Roy, Gautier Follain, Romain F. Laine, Lucas von Chamier, Pekka E. Hänninen, John E. Eriksson, Jean-Yves Tinevez, Guillaume Jacquemet

Publikováno v: F1000Research, Vol 9 (2020)

The ability of cells to migrate is a fundamental physiological process involved in embryonic development, tissue homeostasis, immune surveillance, and wound healing. Therefore, the mechanisms governing cellular locomotion have been under intense scru

Externí odkaz: https://doaj.org/article/dc0615b3c30149aa8c4230c5fcf6dde1

Density and function of actin-microdomains in healthy and NF1 deficient osteoclasts revealed by combined use of AFM and STED-microscopy

Autor: Takahiro Deguchi, Elnaz Fazeli, Sami Koho, Paula Pennanen, Maria Alanne, Mayank Modi, John Eriksson, Kari Vienola, Pekka Hänninen, Juha Peltonen, Tuomas Näreoja

Publikováno v: Bone Reports, Vol 13, Iss , Pp 100454- (2020)

Externí odkaz: https://doaj.org/article/ed4360210b364430ace61bc50fac18ff

Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer

Autor: Anne Mette G. Jensen, Yu Kitago, Elnaz Fazeli, Christian B. Vægter, Scott A. Small, Gregory A. Petsko, Olav M. Andersen

Publikováno v: Jensen, A M G, Kitago, Y, Fazeli, E, Vægter, C B, Small, S A, Petsko, G A & Andersen, O M 2023, ' Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer ', Proceedings of the National Academy of Sciences, vol. 120, no. 4, e2212180120 . https://doi.org/10.1073/pnas.2212180120

SORL1 , the gene encoding the large multidomain SORLA protein, has emerged as only the fourth gene that when mutated can by itself cause Alzheimer’s disease (AD), and as a gene reliably linked to both the early- and late-onset forms of the disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789be2709cc6de06e9087452c46e1ba1
https://pure.au.dk/portal/da/publications/dimerization-of-the-alzheimers-disease-pathogenic-receptor-sorla-regulates-its-association-with-retromer(4cd16520-6b3c-4451-acc7-b0fd6b8859e4).html

Delivery of genome editing tools: A promising strategy for HPV-related cervical malignancy therapy

Autor: Mahsa Keshavarz-Fathi, Sam Talaei, Shahin Aghamiri, Omid Kheiry Avarvand, Mansur Aliyu, Hossein Ghanbarian, Zahra Ebrahimi, Farshid Zandsalimi, Soheil Roshanzamiri, Elnaz Fazeli

Publikováno v: Expert Opinion on Drug Delivery. 17:753-766

Persistent high-risk human papillomavirus infection is the main cause of various types of cancer especially cervical cancer. The E6 and E7 oncoproteins of HPV play critical roles in promoting carcinogenesis and cancer cell growth. As a result, E6 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf38f5337a36653f1fa650c43bfe21f
https://doi.org/10.1080/17425247.2020.1747429

Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1

Autor: Eija Martikkala, Roope A. Kallionpää, Ilmo Leivo, Sirkku Peltonen, Anne Rokka, Elnaz Fazeli, Kaisa Ahramo, Pekka Haapaniemi, Juha Peltonen, Ilkka T. Harvima

Publikováno v: Dermatology (Basel, Switzerland). 238(2)

Background: Cutaneous neurofibromas (cNFs) are hallmarks of neurofibromatosis 1 (NF1) and cause the main disease burden in adults with NF1. Mast cells are a known component of cNFs. However, no comprehensive characterization of mast cells in cNFs is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc55f79f3c6bc4fe79c733340afccc27
https://pubmed.ncbi.nlm.nih.gov/34237737