Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays

Autor: Shen, K, Luk, S, Hicks, DF, Elman, JS, Bohr, S, Iwamoto, Y, Murray, R, Pena, K, Wang, F, Seker, E, Weissleder, R, Yarmush, ML, Toner, M, Sgroi, D, Parekkadan, B

Publikováno v: Nature communications, vol 5, iss 1
Shen, K; Luk, S; Hicks, DF; Elman, JS; Bohr, S; Iwamoto, Y; et al.(2014). Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nature Communications, 5. doi: 10.1038/ncomms6662. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6f08595z

© 2014 Macmillan Publishers Limited. All rights reserved. Tumour-stromal interactions are a determining factor in cancer progression. In vivo, the interaction interface is associated with spatially resolved distributions of cancer and stromal phenot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ca538d8d2981c5719ac91c55b2c4ee1d
https://escholarship.org/uc/item/6f08595z

Premature polyadenylation of MAGI3 is associated with diminished N ⁶ -methyladenosine in its large internal exon.

Autor: Ni TK; Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA, 02111, USA.; Raymond & Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA, 02111, USA.; Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington St, Boston, MA, 02111, USA., Elman JS; Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA, 02111, USA.; Raymond & Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA, 02111, USA.; Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington St, Boston, MA, 02111, USA., Jin DX; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Gupta PB; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Kuperwasser C; Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA, 02111, USA. charlotte.kuperwasser@tufts.edu.; Raymond & Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA, 02111, USA. charlotte.kuperwasser@tufts.edu.; Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington St, Boston, MA, 02111, USA. charlotte.kuperwasser@tufts.edu.

Publikováno v: Scientific reports [Sci Rep] 2018 Jan 23; Vol. 8 (1), pp. 1415. Date of Electronic Publication: 2018 Jan 23.

Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.

Autor: Shen K; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA., Luk S; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA., Hicks DF; Department of Pathology, Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA., Elman JS; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA., Bohr S; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA., Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., Murray R; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA., Pena K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA., Wang F; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA., Seker E; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA., Weissleder R; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., Yarmush ML; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA., Toner M; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA., Sgroi D; Department of Pathology, Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA., Parekkadan B; 1] Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA [2] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.

Publikováno v: Nature communications [Nat Commun] 2014 Dec 09; Vol. 5, pp. 5662. Date of Electronic Publication: 2014 Dec 09.

Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.

Autor: Milwid JM; 1] Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA [2] Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Elman JS; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Li M; 1] Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA [2] Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA [3] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Shen K; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Manrai A; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Gabow A; Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Yarmush J; Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA., Jiao Y; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Fletcher A; Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Lee J; Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Cima MJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Yarmush ML; 1] Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA [2] Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA., Parekkadan B; 1] Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA [2] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2014 May; Vol. 22 (5), pp. 999-1007. Date of Electronic Publication: 2014 Feb 05.

A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation.

Autor: Elman JS, Li M, Wang F, Gimble JM, Parekkadan B; Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children in Boston, Boston, MA 02114, USA. biju_parekkadan@hms.harvard.edu.

Publikováno v: Journal of inflammation (London, England) [J Inflamm (Lond)] 2014 Jan 07; Vol. 11 (1), pp. 1. Date of Electronic Publication: 2014 Jan 07.