Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Elma Zaganjor"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Obesity is a growing health concern worldwide because of its contribution to metabolic syndrome, type II diabetes, insulin resistance (IR), and numerous cancers. In obesity, white adipose tissue (WAT) expands through two mechanisms: increase in adipo
Externí odkaz:
https://doaj.org/article/3acbca6a0f7f46408c00cde1e90b1fba
Autor:
Abhijit B. Shinde, Elma Zaganjor
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100429- (2021)
In this issue of Cell Reports Medicine, Lange and colleagues1 significantly improve lipid identification accuracy, detection, and quantification to provide AdipoAtlas, an in-depth lipidomic profile of human white adipose tissue (WAT). Importantly, th
Externí odkaz:
https://doaj.org/article/7f394ba3d3074c87847196ce300f8e2e
Autor:
Elma Zaganjor, Haejin Yoon, Jessica B. Spinelli, Elizabeth R. Nunn, Gaëlle Laurent, Paulina Keskinidis, Suganja Sivaloganathan, Shakchhi Joshi, Giulia Notarangelo, Stacy Mulei, Mathew T. Chvasta, Sarah A. Tucker, Krystle Kalafut, Robert A.H. van de Ven, Clary B. Clish, Marcia C. Haigis
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109345- (2021)
Summary: Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature adipocytes capable of storing nutrients as fat. We profiled cellular metabolite consumption to identify early metabolic drivers of adipocyte different
Externí odkaz:
https://doaj.org/article/eeafed29f9144a1b9b6dcdb9a20bf900
Autor:
Karina N. Gonzalez Herrera, Elma Zaganjor, Yoshinori Ishikawa, Jessica B. Spinelli, Haejin Yoon, Jia-Ren Lin, F. Kyle Satterstrom, Alison Ringel, Stacy Mulei, Amanda Souza, Joshua M. Gorham, Craig C. Benson, Jonathan G. Seidman, Peter K. Sorger, Clary B. Clish, Marcia C. Haigis
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 1945-1955 (2018)
Summary: Sirtuin 3 (SIRT3) is a NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration and in high-fat diet (HFD)-induced metabolic disorders. Here, we performed a small-molecule screen and
Externí odkaz:
https://doaj.org/article/51a8f19ab26748a8ba8f2357ab0736c7
Autor:
Stina M. Singel, Crystal Cornelius, Elma Zaganjor, Kimberly Batten, Venetia R. Sarode, Dennis L. Buckley, Yan Peng, George B. John, Hsiao C. Li, Navid Sadeghi, Woodring E. Wright, Lawrence Lum, Timothy W. Corson, Jerry W. Shay
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 3, Pp 247-256.e2 (2014)
Despite evidence that kinesin family member 14 (KIF14) can serve as a prognostic biomarker in various solid tumors, how it contributes to tumorigenesis remains unclear. We observed that experimental decrease in KIF14 expression increases docetaxel ch
Externí odkaz:
https://doaj.org/article/6c64beef889741d38f469bb388b70ed5
Autor:
Amber Crabtree, Kit Neikirk, Andrea G. Marshall, Larry Vang, Dominique Stephens, Bryanna Shao, Edgar Garza Lopez, Jacob Lam, Ben Rodriguez, Margaret Mungai, Jade Stanley, Danielle Dean, Jennifer A. Gaddy, Estevão Scudese, Mariya Sweetwyne, Jamaine Davis, Elma Zaganjor, Sandra A. Murray, Prasanna Katti, Steven M. Damo, Zer Vue, Antentor Hinton
Mitochondria are required for energy production and even give brown adipose tissue (BAT) its characteristic color due to their high iron content and abundance The physiological function and bioenergetic capacity of mitochondria are connected to the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32eae670f663d59d15e80b1a3dd418c3
https://doi.org/10.1101/2023.05.12.540609
https://doi.org/10.1101/2023.05.12.540609
Autor:
Brandon M. Cuevas, Katerina Politi, Bomiao Hu, Charles P. Fulco, Pratiksha I. Thakore, Michael S. Cuoco, Jan-Christian Hütter, William Colgan, Aaron N. Hata, Sara A. Hurvitz, Kerry A. Pierce, Amy Deik, Liat Amir-Zilberstein, Marcin Tabaka, Joan S. Brugge, Dennis J. Slamon, Aviv Regev, Galit Lahav, Michael Tsabar, Clary B. Clish, Yaara Oren, Elma Zaganjor, Heidie Frisco Cabanos
Publikováno v:
Nature, vol 596, iss 7873
Nature
Nature
Non-genetic mechanisms have recently emerged as important drivers of cancer therapy failure1, where some cancer cells can enter a reversible drug-tolerant persister state in response to treatment2. Although most cancer persisters remain arrested in t
Autor:
Giulia Notarangelo, Jessica B. Spinelli, Elizabeth M. Perez, Gregory J. Baker, Kiran Kurmi, Ilaria Elia, Sylwia A. Stopka, Gerard Baquer, Jia-Ren Lin, Alexandra J. Golby, Shakchhi Joshi, Heide F. Baron, Jefte M. Drijvers, Peter Georgiev, Alison E. Ringel, Elma Zaganjor, Samuel K. McBrayer, Peter K. Sorger, Arlene H. Sharpe, Kai W. Wucherpfennig, Sandro Santagata, Nathalie Y. R. Agar, Mario L. Suvà, Marcia C. Haigis
Publikováno v:
Science
Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the production of d -2-hydroxyglutarate ( d -2HG), an oncometabolite that promotes tumorigenesis through epigenetic alterations. The cancer cell–intrinsic effec
Autor:
Abhijit B. Shinde, Elizabeth R. Nunn, Genesis A. Wilson, Mathew T. Chvasta, Julia A. Pinette, Jacob W. Myers, Sun H. Peck, Jessica B. Spinelli, Elma Zaganjor
Publikováno v:
Journal of Biological Chemistry. 299:104635
Autor:
Jessica Brooke Spinelli, Elma Zaganjor
Publikováno v:
Nature cell biology. 24(2)