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Akademický článek

Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation.

Autor: Bram J van Raam, Wim Sluiter, Elly de Wit, Dirk Roos, Arthur J Verhoeven, Taco W Kuijpers

Publikováno v: PLoS ONE, Vol 3, Iss 4, p e2013 (2008)

BACKGROUND: Neutrophils depend mainly on glycolysis for their energy provision. Their mitochondria maintain a membrane potential (Deltapsi(m)), which is usually generated by the respiratory chain complexes. We investigated the source of Deltapsi(m) i

Externí odkaz: https://doaj.org/article/4a2f721255be4748a235d867d466d75b

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Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys

Autor: Hitoshi Kurata, Daisuke Nakai, Elly de Wit, Keita Kono, Takafumi Kohama, Arthur Gerritsen van der Hoop, Louis H. Cohen, Ken Kitayama, Toshimori Inaba

Publikováno v: European Journal of Pharmacology, 1-2, 539, 89-98

1-{7-[(1-(3,5-Diethoxyphenyl)-3-{[(3,5-difluorophenyl)(ethyl)amino]carbo nyl}-4-oxo-1,4-dihydroquinolin-7-yl)oxy]heptyl}-1-methylpiperidinium bromide, R-146224, is a potent, specific ileum apical sodium-dependent bile acid transporter (ASBT) inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ce39e9ca5781489a9eb38342fd37b4
https://doi.org/10.1016/j.ejphar.2006.04.005

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Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels

Autor: Anne-Marie Zuurmond, Ernst A. van Dura, Ruud A. Bank, Tom W J Huizinga, Jeroen DeGroot, Elly de Wit, Annemarie J. van der Slot

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1741(1-2):95-102

The hallmark of fibrosis is the excessive accumulation of collagen. The deposited collagen contains increased pyridinoline cross-link levels due to an overhydroxylation of lysine residues within the collagen telopeptides. Lysyl hydroxylase 2b (LH2b)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bbdca854f81ce1e54bbb7e1c0a19c0

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Rosuvastatin Reduces Plasma Lipids by Inhibiting VLDL Production and Enhancing Hepatobiliary Lipid Excretion in ApoE*3-Leiden Mice

Autor: Hans van der Boom, Karianne Solaas, Hans M.G. Princen, Vincent W. Bloks, Dianne J.M. Delsing, Folkert Kuipers, Wim van Duyvenvoorde, S.M. Post, Martine Groenendijk, Louis M. Havekes, Elly de Wit

Publikováno v: Journal of Cardiovascular Pharmacology, 45(1), 53-60
Journal of Cardiovascular Pharmacology, 1, 45, 53-60

The present study was designed to investigate the lipid-lowering properties and mechanisms of action of a new HMG-CoA reductase inhibitor, rosuvastatin, in female ApoE*3-Leiden transgenic mice. Mice received a high fat/cholesterol (HFC) diet containi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f13c639e67855a7cd59338222e2a93
https://doi.org/10.1097/00005344-200501000-00010

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HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice

Autor: Oscar L. Volger, Richard Draijer, Hans M.G. Princen, V.E.H. Dahlmans, Louis M. Havekes, Elly de Wit

Publikováno v: Biochemical Pharmacology. 63:1755-1761

Previous rodent studies suggested that the potent hypolipidemic agent 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)pyrimidine-5-N-(trifluoromethyl-phenyl) carboxamide monohydrochloride (HOE 402) is an inducer of the LDL receptor (LDLR). Using wild-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056cba0bd9d3eed7efb53bddf7efe0b3
https://doi.org/10.1016/s0006-2952(02)00898-5

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Dietary plant stanol esters reduce VLDL cholesterol secretion and bile saturation in apolipoprotein E*3-Leiden transgenic mice

Autor: Hans van der Boom, Oscar L. Volger, Gerard Hornstra, Elly de Wit, Jogchum Plat, Louis M. Havekes, Wim van Duyvenvoorde, Hans M.G. Princen, Ronald P. Mensink

Publikováno v: Arteriosclerosis Thrombosis and Vascular Biology, 21, 1046-1052. LIPPINCOTT WILLIAMS & WILKINS

Arterioscler Thromb Vasc Biol 2001 Jun;21(6):1046-52 Related Articles, Books, LinkOut Dietary plant stanol esters reduce VLDL cholesterol secretion and bile saturation in apolipoprotein E*3-Leiden transgenic mice.Volger OL, van der Boom H, de Wit EC,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94b440ab7d1ffc5147a7505dee3958d
https://doi.org/10.1161/01.atv.21.6.1046

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Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat

Autor: Mettine H.A. Bos, Hans M.G. Princen, Elly de Wit, Folkert Kuipers, Rick Havinga, J. Paul Zoeteweij, S.M. Post

Publikováno v: Hepatology (Baltimore, Md.). 30(2)

Acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors are currently in clinical development as potential lipid-lowering and antiatherosclerotic agents. We investigated the effect of avasimibe (Cl- 1011), a novel ACAT inhibitor, on bile acid s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5451c075d8d1778bab3ce5b739a5b608
https://pubmed.ncbi.nlm.nih.gov/10421659

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The effect of the apolipoprotein E phenotype on plasma lipids is not influenced by environmental variability: results of a Dutch twin study

Autor: Rune R. Frants, Jan A. Gevers Leuven, Peter de Knijff, Louis M. Havekes, Elly de Wit, H.J.M. Kempen, Dorret I. Boomsma

Publikováno v: de Knijff, P, Boomsma, D I, de Wit, E, Kempen, H J M, Gevers-Leuven, J A, Frants, R R & Havekes, L M 1993, ' The effect of the apolipoprotein E phenotype on plasma lipids is not influenced by environmental variability: results of a Dutch twin study ', Human Genetics, vol. 91, no. 3, pp. 268-272 . https://doi.org/10.1007/BF00218269
Human Genetics, 91(3), 268-272. Springer Verlag

We tested the influence of the apolipoprotein E (apoE) polymorphism on the intrapair differences in the levels of plasma cholesterol, plasma triglycerides, low density lipoprotein-cholesterol, apoB and apoE in monozygotic (MZ) twins, and estimated wh

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Characterisation of the binding of apolipoprotein E-free high density lipoprotein to cultured human endothelial cells

Autor: D. Schouten, Elly de Wit, Louis M. Havekes, Victor W.M. van Hinsbergh

Publikováno v: Biochemical and Biophysical Research Communications. 122:785-790

[125I]-labelled apolipoprotein E-free high density lipoprotein (apo E-free HDL) binds to cultured human endothelial cells with high affinity. Competitive binding experiments showed that complexes of egg phosphatidyl choline with respectively apo A-1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531ded912353871a4cc086068ce39b35
https://doi.org/10.1016/s0006-291x(84)80102-3

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Regulation of low density lipoprotein receptor activity in primary cultures of human hepatocytes by serum lipoproteins

Autor: Hans M.G. Princen, Sing Hiem Yap, Louis M. Havekes, Elly de Wit, Hans Verboom

Publikováno v: Hepatology. 6:1356-1360

The low density lipoprotein receptor activity was measured in primary cultures of human hepatocytes. The receptor-mediated association and degradation of low density lipoprotein increased gradually up to 140 and 190%, respectively, upon incubation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617818c829d99bb52c7101c66701d8ac
https://doi.org/10.1002/hep.1840060623

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