Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production.

Autor: Wang C; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Khatun MS; Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, USA., Ellsworth CR; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Chen Z; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Islamuddin M; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Nisperuza Vidal AK; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Afaque Alam M; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Liu S; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Mccombs JE; Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, USA., Maness NJ; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Blair RV; Tulane National Primate Research Center, Covington, LA, USA., Kolls JK; Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, USA., Qin X; Tulane National Primate Research Center, Covington, LA, USA. xqin2@tulane.edu.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. xqin2@tulane.edu.

Publikováno v: Communications biology [Commun Biol] 2024 Sep 17; Vol. 7 (1), pp. 1162. Date of Electronic Publication: 2024 Sep 17.

Natural Killer Cells Do Not Attenuate a Mouse-Adapted SARS-CoV-2-Induced Disease in Rag2 ^-/- Mice.

Autor: Ellsworth CR; Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Wang C; Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Katz AR; Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA., Chen Z; Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Islamuddin M; Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Yang H; Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Scheuermann SE; Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA., Goff KA; Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA., Maness NJ; Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Blair RV; Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA., Kolls JK; Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Qin X; Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Publikováno v: Viruses [Viruses] 2024 Apr 15; Vol. 16 (4). Date of Electronic Publication: 2024 Apr 15.

COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes.

Autor: Wang C; Tulane National Primate Research Center, Covington, LA, 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Khatun MS; Department of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Zhang Z; Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Allen MJ; Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Chen Z; Tulane National Primate Research Center, Covington, LA, 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Ellsworth CR; Tulane National Primate Research Center, Covington, LA, 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Currey JM; Tulane National Primate Research Center, Covington, LA, 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Dai G; Department of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Tian D; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Bach K; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Yin XM; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Traina-Dorge V; Tulane National Primate Research Center, Covington, LA, 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Rappaport J; Tulane National Primate Research Center, Covington, LA, 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Maness NJ; Tulane National Primate Research Center, Covington, LA, 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Blair RV; Tulane National Primate Research Center, Covington, LA, 70433, USA., Kolls JK; Department of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Pociask DA; Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA. dpociask@tulane.edu., Qin X; Tulane National Primate Research Center, Covington, LA, 70433, USA. xqin2@tulane.edu.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA. xqin2@tulane.edu.

Publikováno v: Communications biology [Commun Biol] 2023 Dec 13; Vol. 6 (1), pp. 1265. Date of Electronic Publication: 2023 Dec 13.