Combined CD8+ and CD4+ adenovirus hexon-specific T cells associated with viral clearance after stem cell transplantation as treatment for adenovirus infection

Autor: Maarten L. Zandvliet, J.H. Frederik Falkenburg, Ellis van Liempt, Louise A. Veltrop-Duits, Arjan C. Lankester, Jayant S. Kalpoe, Michel G.D. Kester, Dirk M. van der Steen, Maarten J. van Tol, Roel Willemze, Henk-Jan Guchelaar, Marco W. Schilham, Pauline Meij

Publikováno v: Haematologica, Vol 95, Iss 11 (2010)

Background Human adenovirus can cause morbidity and mortality in immunocompromised patients after allogeneic stem cell transplantation. Reconstitution of adenovirus-specific CD4+ T cells has been reported to be associated with sustained protection fr

Externí odkaz: https://doaj.org/article/6a6d375cdf8c40048c596327347ce026

Generation and infusion of multi-antigen-specific T cells to prevent complications early after T-cell depleted allogeneic stem cell transplantation-a phase I/II study

Autor: Marthe C J, Roex, Peter, van Balen, Lothar, Germeroth, Lois, Hageman, Esther, van Egmond, Sabrina A J, Veld, Conny, Hoogstraten, Ellis, van Liempt, Jaap J, Zwaginga, Liesbeth C, de Wreede, Pauline, Meij, Ann C T M, Vossen, Sophia, Danhof, Hermann, Einsele, M Ron, Schaafsma, Hendrik, Veelken, Constantijn J M, Halkes, Inge, Jedema, J H Frederik, Falkenburg

Publikováno v: Leukemia. 34(3)

Prophylactic infusion of selected donor T cells can be an effective method to restore specific immunity after T-cell-depleted allogeneic stem cell transplantation (TCD-alloSCT). In this phase I/II study, we aimed to reduce the risk of viral complicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d8ce3579b4cce47b26ef2b10cf70846
https://pubmed.ncbi.nlm.nih.gov/31624377

The simultaneous isolation of multiple high and low frequent T-cell populations from donor peripheral blood mononuclear cells using the major histocompatibility complex I-Streptamer isolation technology

Autor: Inge Jedema, Sabrina A.J. Veld, J.H. Frederik Falkenburg, Ellis van Liempt, Lothar Germeroth, Marthe C.J. Roex, Lois Hageman, Michel G.D. Kester, Christian Stemberger, Matthias T. Heemskerk

Publikováno v: Cytotherapy, 20(4), 543-555

Background Adoptive transfer of donor-derived T cells can be applied to improve immune reconstitution in immune-compromised patients after allogeneic stem cell transplantation. The separation of beneficial T cells from potentially harmful T cells can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81480cdb5c3e2c6f72e00a9dca2d2d8e
https://hdl.handle.net/1887/96115

Efficiency and Mechanism of Antigen-specific CD8+ T-cell Activation Using Synthetic Long Peptides

Autor: Henk-Jan Guchelaar, Pauline Meij, Marieke Griffioen, Maarten L. Zandvliet, J.H. Frederik Falkenburg, Michel G.D. Kester, Peter A. van Veelen, Arnoud H. de Ru, Ellis van Liempt

Publikováno v: Journal of Immunotherapy
Journal of Immunotherapy, 35(2), 142-153

Synthetic long peptides that contain immunogenic T-cell epitopes have been used to induce activation of antigen-specific CD8 T cells in vitro for immune monitoring or adoptive transfer, or in vivo after peptide vaccination. However, the efficiency an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d964800d990269611c1a92618ec2bca7
https://doi.org/10.1097/cji.0b013e318243f1ed

DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2

Autor: Teunis B.H. Geijtenbeek, Cora Beckers, Irma van Die, Ellis van Liempt, Bert van het Hof, Sonja I. Gringhuis, Juan J. Garcia-Vallejo, Jaap-Jan Zwaginga, Yvette van Kooyk, Paula A. da Costa Martins, Willem Van Dijk

Publikováno v: Molecular Immunology, 45(8), 2359-2369. Elsevier Limited
Garcia Vallejo, J J, Liempt, P A G, da Costa Martins, P, Beckers, C M L, van het Hof, B, Gringhuis, S I, Zwaginga, JJ, van Dijk, W, Geijtenbeek, T B H, van Kooyk, Y & van Die, I M 2008, ' DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2 ', Molecular Immunology, vol. 45, no. 8, pp. 2359-2369 . https://doi.org/10.1016/j.molimm.2007.11.001
Molecular immunology, 45(8), 2359-2369. Elsevier Limited

Immature dendritic cells (DCs) are recruited from blood into tissues to patrol for foreign antigens. After antigen uptake and processing, DCs mature and migrate to the secondary lymphoid organs where they initiate immune responses. DC-SIGN is a DC-sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055b506c6cad84bb17a54bd592a62eb0
https://doi.org/10.1016/j.molimm.2007.11.001